pirinixic acid has been researched along with clofibric acid in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.00) | 18.7374 |
| 1990's | 24 (48.00) | 18.2507 |
| 2000's | 18 (36.00) | 29.6817 |
| 2010's | 1 (2.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crestani, M; Fracchiolla, G; Fruchart, JC; Godio, C; Laghezza, A; Lavecchia, A; Loiodice, F; Mitro, N; Novellino, E; Pinelli, A; Staels, B; Tortorella, V | 1 |
| Bleve, L; Colabufo, NA; Jockers, R; Milazzo, FM; Perrone, MG; Santandrea, E; Sciarroni, AF; Scilimati, A; Vitale, P | 1 |
| Conte Camerino, D; Fracchiolla, G; Laghezza, A; Lavecchia, A; Loiodice, F; Mazza, F; Montanari, R; Novellino, E; Piemontese, L; Pierno, S; Pochetti, G; Tortorella, P | 1 |
| Ammazzalorso, A; Amoroso, R; Brunetti, L; Bruno, I; Cama, A; Capone, F; Cerchia, C; De Filippis, B; Fantacuzzi, M; Ferrante, C; Florio, R; Giampietro, L; Laghezza, A; Lavecchia, A; Loiodice, F; Maccallini, C; Recinella, L; Tortorella, P; Verginelli, F | 1 |
| Goldsworthy, TL; Marsman, DS; Popp, JA | 1 |
| Cannon, JR; Eacho, PI | 1 |
| Gemmell, MA; Giometti, CS; Lalwani, ND; Reddy, JK; Taylor, J; Tollaksen, SL | 2 |
| Brodhecker, CA; Eacho, PI; Lanier, TL | 1 |
| Danna, TF; Randerath, E; Randerath, K; Rao, MS; Reddy, JK; Reddy, R | 1 |
| Bartles, JR; Fayos, BE; Isoye, ST; Khuon, S; Lin, XH; Nehme, CL; Rao, MS; Reddy, JK; Zhang, LQ | 1 |
| Makino, T; Nemali, MR; Pitot, HC; Rao, MS; Reddy, JK; Scarpelli, DG; Usuda, N | 1 |
| Beer, D; Coloma, J; Glauert, HP; Goldsworthy, TL; Pitot, HC; Rao, MS; Schwarz, M; Xu, YD | 1 |
| Ito, N; Rao, MS; Reddy, JK; Subbarao, V; Tatematsu, M | 1 |
| Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Pfeiffer, DR; Riley, WW | 1 |
| Earley, K; Goel, SK; Gupta, RC; Reddy, JK; Singh, B | 1 |
| Balber, AE; Gonias, SL; Pizzo, SV | 1 |
| Jannin, B; Latruffe, N; Passilly, P | 1 |
| Matsuo, H; Strauss, JF | 1 |
| Alvares, K; Capone, JP; Dadras, SS; Fan, C; Iannaccone, PM; Rachubinski, RA; Rao, MS; Reddy, JK; Subramani, S; Yeldandi, AV | 1 |
| Cattley, RC; Glover, SE | 1 |
| Bartles, JR; Fayos, BE | 1 |
| Davies, MJ; Lake, BG; Price, RJ; Rumsby, PC | 1 |
| Marsman, DS; Popp, JA; Swanson-Pfeiffer, CL | 1 |
| Adam, M; Boie, Y; Kennedy, BP; Rushmore, TH | 1 |
| Beamand, JA; Cunninghame, ME; Lake, BG; Price, RJ | 1 |
| Anderson, NL; Eacho, P; Esquer-Blasco, R; Foxworthy, P; Richardson, F | 1 |
| Beamand, JA; Charzat, C; Lake, BG; Price, RJ; Renwick, AB; Tredger, JM | 1 |
| Galloway, SM; Johnson, TE; Ledwith, BJ; Manam, S; Nichols, WW; Pauley, CJ; Wagner, LK | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Hashimoto, T; Maeda, N; Pan, J; Pulikuri, S; Qi, C; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV; Zhu, Y | 1 |
| Wallace, KB; Zhou, S | 1 |
| Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T | 1 |
| Chi, SY; Eggers, CM; Gonzalez, FJ; Guidotti, LG; McLachlan, A; Peters, JM; Raney, AK | 1 |
| Cunninghame, ME; Lake, BG; Price, RJ; Rumsby, PC | 1 |
| Chiang, JY; Marrapodi, M | 1 |
| Duez, H; Gervois, PP; Kuipers, F; Post, SM; Princen, HM; Staels, B | 1 |
| Bakke, I; Hammer, TA; Sandvik, AK; Waldum, HL | 1 |
| Bloks, VW; Havinga, R; Jansen, PL; Kok, T; Kuipers, F; Staels, B; Wolters, H | 1 |
| Fujiwara, Y; Harris, RA; Jaskiewicz, J; Kobayashi, R; Murakami, T; Nakai, N; Obayashi, M; Shimomura, Y | 1 |
| Ammerschlaeger, M; Beigel, J; Klein, KU; Mueller, SO | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Bournot, P; Chevillard, G; Duclos, S; Le Jossic-Corcos, C; Martin, P; Pineau, T; Ramirez, LC; Zaghini, I | 1 |
| Bhatt, R; Gokden, N; Li, S; Okusa, MD; Portilla, D | 1 |
| Barbier, O; Bélanger, J; Caron, P; Grepper, S; Inaba, TT; Kaeding, J; Monté, D; Trottier, J; Verreault, M | 1 |
| Dongol, B; Gonzalez, FJ; Hunt, MC; Kim, I; Shah, Y | 1 |
| Hannig, M; Piper, HM; Sauer, H; Sharifpanah, F; Wartenberg, M | 1 |
| Balendiran, GK; Haq, W; Martin, HJ; Maser, E; O'Connor, TR; Verma, M | 1 |
| Hashimoto, F; Hayashi, H; Iwasaki, K; Morita, M; Takeda, S | 1 |
50 other study(ies) available for pirinixic acid and clofibric acid
| Article | Year |
|---|---|
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Topics: 3T3 Cells; Adipocytes; Animals; Binding Sites; Cell Differentiation; Cell Line, Tumor; Clofibric Acid; Endopeptidase K; Fibroblasts; Humans; Ligands; Mice; Models, Molecular; Phenylpropionates; PPAR alpha; PPAR gamma; Protein Conformation; Quantitative Structure-Activity Relationship; Stereoisomerism; Trypsin | 2005 |
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Topics: Adenylyl Cyclases; Adrenergic beta-3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Inverse Agonism; Humans; Molecular Structure; Receptors, Adrenergic, beta-3; Stereoisomerism; Structure-Activity Relationship | 2008 |
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Topics: Animals; Cell Line, Tumor; Chloride Channels; Chlorides; Clofibric Acid; Crystallography, X-Ray; Drug Discovery; Electric Conductivity; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligands; Male; Models, Molecular; Molecular Conformation; Muscle, Skeletal; Muscular Diseases; PPAR alpha; PPAR gamma; Propionates; Rats; Rats, Wistar; Rest; Stereoisomerism; Substrate Specificity | 2009 |
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.
Topics: | 2019 |
Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid.
Topics: Animals; Body Weight; Carcinogenicity Tests; Cell Death; Cell Division; Clofibric Acid; DNA, Neoplasm; Eating; Lipofuscin; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Pyrimidines; Rats; Rats, Inbred F344; Time Factors | 1992 |
Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver.
Topics: Acetophenones; Animals; Bezafibrate; Carrier Proteins; Clofibric Acid; Electrophoresis, Polyacrylamide Gel; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fibric Acids; Male; Microbodies; Neoplasm Proteins; Nerve Tissue Proteins; Oleic Acid; Oleic Acids; Pyrimidines; Rats; Rats, Inbred F344; SRS-A; Tetrazoles | 1991 |
A comparative study of the effects of clofibrate, ciprofibrate, WY-14,643, and di-(2-ethylhexyl)-phthalate on liver protein expression in mice.
Topics: Animals; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Female; Fibric Acids; Hypolipidemic Agents; Liver; Male; Membrane Proteins; Mice; Microbodies; Pyrimidines | 1991 |
Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14,643 to clofibric acid, nafenopin and LY171883.
Topics: Acetophenones; Animals; Bromodeoxyuridine; Clofibric Acid; DNA Replication; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Oxidation-Reduction; Pyrimidines; Rats; Rats, Inbred F344; Tetrazoles | 1991 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Mice; Proteins; Pyrimidines | 1991 |
Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling.
Topics: Affinity Labels; Animals; Clofibric Acid; DNA Damage; DNA, Neoplasm; Fibric Acids; Hypolipidemic Agents; Liver; Liver Neoplasms; Male; Microbodies; Mutagens; Pyrimidines; Rats; Rats, Inbred F344 | 1991 |
Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.
Topics: Antibodies, Monoclonal; Asialoglycoprotein Receptor; Blotting, Western; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; ErbB Receptors; Fibric Acids; Fluorescent Antibody Technique; Isoelectric Point; Liver; Membrane Glycoproteins; Microbodies; Pyrimidines; Receptors, Immunologic; Sialoglycoproteins | 1990 |
Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.
Topics: alpha-Fetoproteins; Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Liver Neoplasms, Experimental; Microbodies; Neoplasm Transplantation; Pyrimidines; Rats; RNA, Messenger | 1988 |
Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Diethylnitrosamine; Drug Administration Schedule; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Immunologic Techniques; Liver; Microbodies; Pyrimidines; Rats; Time Factors | 1986 |
Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.
Topics: Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Placenta; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
The effect of Ca2+ and acyl coenzyme A:lysophospholipid acyltransferase inhibitors on permeability properties of the liver mitochondrial inner membrane.
Topics: Acyltransferases; Animals; Calcium; Cell Membrane Permeability; Clofibric Acid; Dithiothreitol; Fatty Acids, Nonesterified; Glutathione; Hypolipidemic Agents; Intracellular Membranes; Male; Mitochondria, Liver; Oxidation-Reduction; Pyrimidines; Rats; Rats, Inbred Strains | 1986 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; DNA; Fibric Acids; Hypolipidemic Agents; In Vitro Techniques; Liver; Liver Neoplasms; Male; Microbodies; Phosphorus Radioisotopes; Pyrimidines; Rats | 1985 |
Trypanosoma brucei gambiense: growth in vitro of bloodstream forms inhibited by dichlorodiammineplatinum (II) compounds and hypolipidemic drugs.
Topics: Animals; Bone Marrow; Cells, Cultured; Cisplatin; Clofibric Acid; Mice; Pyrimidines; Trypanosoma brucei gambiense | 1985 |
Influence of peroxisome proliferators on phosphoprotein levels in human and rat hepatic-derived cell lines.
Topics: Animals; Cell Line; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Liver; Microbodies; Oxidoreductases; Phosphoproteins; Phosphorylation; Pyrimidines; Rats | 1995 |
Peroxisome proliferators and retinoids affect JEG-3 choriocarcinoma cell function.
Topics: Carrier Proteins; Cell Division; Cholesterol Side-Chain Cleavage Enzyme; Choriocarcinoma; Chorionic Gonadotropin; Clofibric Acid; Gene Expression; Microbodies; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Retinoids; RNA, Messenger; Sterols; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1994 |
An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Clofibric Acid; Diethylhexyl Phthalate; Enoyl-CoA Hydratase; Fibric Acids; Genes, Reporter; Liver; Luciferases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microbodies; Nafenopin; Pyrimidines | 1994 |
Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization.
Topics: Animals; Body Weight; Carcinogens; Cell Nucleus; Clofibric Acid; Diethylhexyl Phthalate; DNA; Guanosine; Liver; Male; Microbodies; Organ Size; Phenobarbital; Pyrimidines; Rats; Rats, Inbred F344 | 1993 |
Regulation of hepatocytic glycoprotein sialylation and sialyltransferases by peroxisome proliferators.
Topics: Animals; Anticholesteremic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; beta-Galactosidase; beta-Galactoside alpha-2,3-Sialyltransferase; Blotting, Western; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Polyacrylamide Gel; Fibric Acids; Glycoproteins; Hypolipidemic Agents; Kinetics; Liver; Male; Membrane Glycoproteins; Microbodies; Molecular Weight; Pyrimidines; Rats; Rats, Inbred F344; RNA, Messenger; Sialoglycoproteins; Sialyltransferases | 1994 |
Effect of some peroxisome proliferators on transforming growth factor-beta 1 gene expression and insulin-like growth factor II/mannose-6-phosphate receptor gene expression in rat liver.
Topics: Animals; Clofenapate; Clofibric Acid; Corn Oil; Gene Expression; Liver; Male; Microbodies; Nafenopin; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 2; Transforming Growth Factor beta | 1994 |
Lack of comitogenicity by the peroxisome proliferator hepatocarcinogens, Wy-14,643 and clofibric acid.
Topics: Animals; Autoradiography; Cell Division; Cells, Cultured; Clofibric Acid; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Liver; Male; Microbodies; Mitogens; Pyrimidines; Rats; Rats, Inbred F344; Transforming Growth Factor beta | 1993 |
Enantioselective activation of the peroxisome proliferator-activated receptor.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Cells, Cultured; Clofibric Acid; DNA; Microbodies; Molecular Sequence Data; Nafenopin; Oxidoreductases; Propionates; Pyrimidines; Quinolines; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Stereoisomerism; Transcription Factors; Transcriptional Activation | 1993 |
Culture of precision-cut liver slices: effect of some peroxisome proliferators.
Topics: Animals; Carnitine O-Acetyltransferase; Clofibric Acid; Culture Media; Culture Techniques; Fibric Acids; Liver; Male; Microbodies; Microscopy, Electron; Nafenopin; Oxidation-Reduction; Palmitoyl Coenzyme A; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
The effects of peroxisome proliferators on protein abundances in mouse liver.
Topics: Acetophenones; Amino Acid Sequence; Animals; Anticholesteremic Agents; Clofibric Acid; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Image Processing, Computer-Assisted; Liver; Male; Mice; Microbodies; Molecular Sequence Data; Nafenopin; Oxidation-Reduction; Proteins; Pyrimidines; Rats; Tetrazoles | 1996 |
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Humans; Isoenzymes; Liver; Male; Microbodies; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley | 1996 |
Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Topics: Animals; Bezafibrate; Carcinogens; Cell Cycle; Cell Line; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Mice; Microbodies; Pyrimidines; Signal Transduction; Time Factors; Transcriptional Activation | 1996 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.
Topics: Animals; Cell Division; Clofibric Acid; DNA Primers; DNA-Binding Proteins; Exons; Fibric Acids; Gene Expression Regulation; Genotype; Histone Acetyltransferases; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Microbodies; Nuclear Receptor Coactivator 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 1999 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.
Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic | 1999 |
In vivo regulation of hepatitis B virus replication by peroxisome proliferators.
Topics: Animals; Clofibric Acid; Female; Hepatitis B e Antigens; Hepatitis B virus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcription, Genetic; Virus Replication | 1999 |
Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig.
Topics: Animals; Cell Division; Clofenapate; Clofibric Acid; Cricetinae; DNA; Fibric Acids; Gene Expression; Guinea Pigs; Liver; Male; Mesocricetus; Molecular Structure; Organ Size; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 2; Species Specificity; Transforming Growth Factor beta | 2000 |
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Topics: Animals; Anticholesteremic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Binding Sites; Cholesterol 7-alpha-Hydroxylase; Clofibric Acid; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hepatocyte Nuclear Factor 4; Humans; Liver; Models, Genetic; Peroxisome Proliferators; Phosphoproteins; Promoter Regions, Genetic; Protein Binding; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Regulatory Sequences, Nucleic Acid; Response Elements; Retinoid X Receptors; Species Specificity; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2000 |
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Clofibric Acid; Cytochrome P-450 Enzyme System; Down-Regulation; Fibric Acids; Hepatocytes; Hypolipidemic Agents; Mice; Mice, Knockout; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Steroid Hydroxylases; Transcription Factors; Transcription, Genetic | 2001 |
PPAR alpha stimulates the rat gastrin-producing cell.
Topics: Animals; Chromans; Clofibric Acid; Female; Fibric Acids; Gastric Mucosa; Gastrins; Ligands; Parietal Cells, Gastric; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bile; Carrier Proteins; Cells, Cultured; Clofibric Acid; Fibric Acids; Hepatocytes; Lipid Metabolism; Lipoproteins; Liver; Male; Membrane Transport Proteins; Mice; Mice, Mutant Strains; Organ Size; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Symporters; Taurochenodeoxycholic Acid; Transcription Factors | 2003 |
Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Administration, Oral; Amino Acids, Branched-Chain; Animals; Clofibric Acid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections; Ketone Oxidoreductases; Ligands; Liver; Male; Multienzyme Complexes; Muscle, Skeletal; Protein Kinases; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Time Factors; Transcription Factors; Weight Gain | 2002 |
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Carnitine Acyltransferases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Hepatocytes; Humans; Male; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Wistar; Response Elements; Species Specificity; Transfection | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.
Topics: Acetates; Animals; Bile Acids and Salts; Carbon Isotopes; Carboxy-Lyases; CCAAT-Enhancer-Binding Proteins; Cell Division; Cholesterol; Clofibric Acid; DNA-Binding Proteins; Fibric Acids; Hepatocytes; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Up-Regulation | 2004 |
Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemokine CCL5; Chemokines; Cisplatin; Clofibric Acid; Cytokines; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Intercellular Adhesion Molecule-1; Mice; Mice, Knockout; Neutrophil Infiltration; NF-kappa B; Nuclease Protection Assays; PPAR alpha; Pyrimidines; Receptors, CCR1; Receptors, CCR5; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.
Topics: Adult; Cell Line; Chenodeoxycholic Acid; Clofibric Acid; DNA-Binding Proteins; Female; Glucuronosyltransferase; Hepatocytes; Humans; Liver; Male; Microbodies; Microsomes, Liver; Middle Aged; PPAR alpha; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2006 |
The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.
Topics: Animals; Binding Sites; Clofibric Acid; Gene Expression Regulation, Enzymologic; Hepatocyte Nuclear Factor 4; Liver; Male; Mice; Mice, Knockout; Palmitoyl-CoA Hydrolase; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Response Elements; Retinoid X Receptor alpha; Thiolester Hydrolases; Transcription Initiation Site | 2007 |
Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Topics: Animals; Butyrates; Cell Differentiation; Cells, Cultured; Clofibric Acid; Embryonic Stem Cells; Enzyme Inhibitors; Fibric Acids; Free Radical Scavengers; Gene Expression; Gene Expression Regulation, Developmental; Heart; Immunohistochemistry; Indoles; Mice; Myocytes, Cardiac; NADPH Oxidases; Peroxisome Proliferators; Phenylurea Compounds; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzothiazoles; Clofibric Acid; Cysteine; Daunorubicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyceraldehyde; Humans; Imidazolidines; Kinetics; Mutation; Neoplasms; Oxidation-Reduction; Phthalazines; Pyrimidines; Recombinant Proteins; Serine | 2008 |
Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells.
Topics: Acyl-CoA Oxidase; Catalase; Cell Culture Techniques; Cell Line; Centrifugation, Density Gradient; Chorionic Gonadotropin; Clofibric Acid; Gemfibrozil; Hormones; Humans; Peroxisome Proliferators; Peroxisomes; Progesterone; Pyrimidines; Trophoblasts | 2009 |