pirinixic acid has been researched along with clofibrate in 82 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (8.54) | 18.7374 |
| 1990's | 30 (36.59) | 18.2507 |
| 2000's | 32 (39.02) | 29.6817 |
| 2010's | 12 (14.63) | 24.3611 |
| 2020's | 1 (1.22) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, PJ; Henke, BR; Sternbach, DD; Willson, TM | 1 |
| Bleve, L; Colabufo, NA; Jockers, R; Milazzo, FM; Perrone, MG; Santandrea, E; Sciarroni, AF; Scilimati, A; Vitale, P | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Rao, MS; Reddy, JK | 1 |
| Göttlicher, M; Gustafsson, JA; Li, Q; Widmark, E | 1 |
| Andersson, K; DePierre, JW; Eriksson, AM; Lundgren, B | 1 |
| Chen, N; Crane, DI | 1 |
| Imanaka, T; Itoga, H; Okawa, S; Suga, T; Watanabe, T | 1 |
| Gemmell, MA; Giometti, CS; Lalwani, ND; Reddy, JK; Taylor, J; Tollaksen, SL | 1 |
| Crane, DI; Masters, CJ; Zamattia, J | 1 |
| Bergstrand, A; DePierre, JW; Karlsson, K; Lundgren, B | 1 |
| Reddy, JK; Schiestl, RH | 1 |
| Bartles, JR; Fayos, BE; Isoye, ST; Khuon, S; Lin, XH; Nehme, CL; Rao, MS; Reddy, JK; Zhang, LQ | 1 |
| Beer, D; Coloma, J; Glauert, HP; Goldsworthy, TL; Pitot, HC; Rao, MS; Schwarz, M; Xu, YD | 1 |
| Chen, N; Crane, DI; Masters, C | 1 |
| Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Earley, K; Goel, SK; Gupta, RC; Reddy, JK; Singh, B | 1 |
| Santilli, AA; Scotese, AC; Tomarelli, RM | 1 |
| D'Atri, G; Galimberti, E; Gomarasca, P; Kritchevsky, D; Sirtori, CR | 1 |
| Drago, J; Fernandez-Salguero, PM; Gonzalez, FJ; Kroetz, DL; Lee, EJ; Lee, SS; Owens, JW; Pineau, T; Westphal, H | 1 |
| Cattley, RC; Lee, DC; Rose, ML; Sausen, PJ | 1 |
| Gonzalez, FJ; McBride, OW; Sher, T; Yi, HF | 1 |
| Kato, R; Murayama, N; Sato, T; Yamazoe, Y | 1 |
| Gibson, GG; Howes, D; Kass, GE; Orrenius, S; Shackleton, GL; Sharma, RK | 1 |
| Byers, DM; Cook, HW; Palmer, FB; Thorne, PC | 1 |
| Aldridge, TC; Green, S; Issemann, I; Prince, RA; Tugwood, JD | 1 |
| Cattley, RC; Kato, M; Popp, JA; Teets, VJ; Voss, KS | 1 |
| Green, S; Wahli, W | 1 |
| Chawla, A; Lazar, MA | 1 |
| Barrett, JC; Tsutsui, T; Watanabe, E | 1 |
| Gonzalez, FJ; Lee, SS; Peters, JM; Ram, PA; Waxman, DJ; Zhou, YC | 1 |
| Galloway, SM; Johnson, TE; Ledwith, BJ; Manam, S; Nichols, WW; Pauley, CJ; Wagner, LK | 1 |
| Gonzalez, FJ; Lee, SS | 1 |
| Gonzalez, FJ; Motojima, K; Peters, JM | 1 |
| Bell, DR; Elcombe, CR; Gray, TJ; Horley, NJ; Plant, NJ; Savory, RL | 1 |
| Gonzalez, FJ; Latruffe, N; Motojima, K; Passilly, P; Peters, JM | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Wallace, KB; Zhou, S | 1 |
| Brun, S; Carmona, MC; Giralt, M; Iglesias, R; Mampel, T; Villarroya, F; Viñas, O | 1 |
| Crew, MD; Dai, G; Gonzalez, FJ; Peters, JM; Portilla, D; Proia, AD | 1 |
| Bianchi, A; Bordji, K; Dauça, M; Gouze, JN; Grillasca, JP; Keller, JM; Magdalou, J; Netter, P; Schohn, H; Terlain, B | 1 |
| Gonzalez, FJ; Jump, DB; Mater, MK; Pan, DA; Peters, JM; Thelen, AP | 1 |
| Brown, WJ; de Figueiredo, P | 1 |
| Conney, AH; Gonzalez, FJ; Peters, JM; Rusyn, I; Thurman, R; Turan, V; Xu, S; Zhu, BT | 1 |
| Auwerx, J; Elias, PM; Feingold, KR; Fluhr, JW; Fowler, AJ; Kao, J; Man, MQ; Schmuth, M; Schoonjans, K; Sheu, MY | 1 |
| Hamano, T; Hayashi, M; Kobayashi, K; Mutai, M; Sakairi, T | 1 |
| Asp, L; Borén, J; Claesson, C; Gustafsson, M; Li, L; Lindberg, K; Lindén, D; Olofsson, SO; Oscarsson, J | 1 |
| Janabi, N | 1 |
| Afshari, CA; Barrett, JC; Bennett, L; Blanchard, K; Bushel, PR; DiSorbo, O; Hamadeh, HK; Jayadev, S; Martin, K; Paules, RS; Sieber, S; Stoll, R; Tennant, R | 1 |
| Baik, EJ; Kim, EJ; Kwon, KJ; Lee, SH; Moon, CH; Park, JY | 1 |
| Chatterjee, PK; Cuzzocrea, S; Hattori, Y; McDonald, MC; Mota-Filipe, H; Pisano, B; Thiemermann, C; Wayman, NS | 1 |
| Ellis, BL; Thiemermann, C; Wayman, NS | 1 |
| Holman, NA; Lee, WJ; May, FJ; Monteith, GR; Roberts-Thomson, SJ; Robinson, JA; Suchanek, KM | 1 |
| Brown, PA; Chatterjee, PK; Hattori, Y; Mota-Filipe, H; Sivarajah, A; Stewart, KN; Thiemermann, C; Todorovic, Z | 1 |
| Dixon, CL; Hebert, C; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Badr, MZ; Bouziane, M; Youssef, JA | 1 |
| Beauregard, C; Brandt, PC | 1 |
| Agellon, LB; Gbaguidi, GF | 1 |
| Ammerschlaeger, M; Beigel, J; Klein, KU; Mueller, SO | 1 |
| Collet, P; Dauça, M; Devignes, MD; Domenjoud, L; Murad, H; Schohn, H | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Fukushima, S; Kikuchi, K; Kushida, M; Mikami, N; Morimura, K; Oeda, K; Okuno, Y; Ozaki, K; Saito, K; Sukata, T; Sumida, K; Uwagawa, S | 1 |
| Aouabdi, S; Gibson, G; Plant, N | 1 |
| Eder, K; Hilgenfeld, C; Koch, A; König, B; Spielmann, J; Stangl, GI | 1 |
| Miyagishima, T; Nagao, T; Ono, A; Tamura, K; Urushidani, T | 1 |
| Catalán, J; Giral, H; Sorribas, V; Villa-Bellosta, R | 1 |
| Banks, T; Oyekan, A | 1 |
| Dordschbal, B; Eder, K; Giggel, K; Koch, A; König, B; Stangl, GI | 1 |
| Kawano, F; Nakai, N; Ohira, T; Ohira, Y; Oke, Y; Terada, M | 1 |
| Crumrine, D; Elias, PM; Feingold, KR; Fluhr, JW; Hachem, JP; Man, MQ; Mauro, TM | 1 |
| Araújo, RM; Baseia, IG; Benevides, NM; Castro, AJ; Cruz, AK; Leite, EL; Lima, LF; Moura, Mde F; Nascimento, MS; Queiroz, LS | 1 |
| Cho, WS; Choi, M; Han, BS; Jeong, J; Park, SN; Son, WC | 1 |
| Anderson, CR; Ferry, CH; Gonzalez, FJ; Palkar, PS; Peters, JM | 1 |
| Azuma, YT; Morioka, A; Nakajima, H; Nishiyama, K; Takeuchi, T | 1 |
| Aneskievich, BJ; Gurevich, I; Zhang, C | 1 |
| Couturier, A; Eder, K; Hirche, F; Keller, J; König, B; Lukas, I; Most, E; Ringseis, R; Spielmann, J; Stangl, GI; Wen, G | 1 |
| Chang, JY; Chang, MD; Chang, SF; Chiu, JJ; Lien, SC; Wei, SY | 1 |
| Burgoon, LD; Chang, CC; Kim, S; Kiyosawa, N; Zacharewski, TR | 1 |
| Amagase, Y; Mizukawa, Y; Urushidani, T | 1 |
3 review(s) available for pirinixic acid and clofibrate
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
Delineating peroxisome proliferator action to improve human risk assessment.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Clofibrate; Cloning, Molecular; Diethylhexyl Phthalate; DNA; Fatty Acids; Humans; Liver; Liver Neoplasms, Experimental; Mice; Microbodies; Molecular Sequence Data; Oxidoreductases; Promoter Regions, Genetic; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Risk Assessment; Transcription Factors; Tretinoin | 1994 |
Peroxisome proliferator-activated receptors: finding the orphan a home.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Carcinogens; Clofibrate; Cytochrome P-450 Enzyme System; Fatty Acids; Hypolipidemic Agents; Liver Neoplasms, Experimental; Mice; Microbodies; Molecular Sequence Data; Multigene Family; Oxidation-Reduction; Oxidoreductases; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Repetitive Sequences, Nucleic Acid; Steroids; Transcription Factors | 1994 |
79 other study(ies) available for pirinixic acid and clofibrate
| Article | Year |
|---|---|
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Topics: Adenylyl Cyclases; Adrenergic beta-3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Inverse Agonism; Humans; Molecular Structure; Receptors, Adrenergic, beta-3; Stereoisomerism; Structure-Activity Relationship | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Pyrimidines; Rats; Rats, Inbred F344 | 1978 |
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Anticholesteremic Agents; Base Sequence; Chimera; CHO Cells; Cholesterol; Clofibrate; Cricetinae; Dehydroepiandrosterone; Dexamethasone; DNA; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Female; Humans; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Placenta; Polymerase Chain Reaction; Pregnancy; Pyrimidines; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Transcription Factors; Transfection | 1992 |
Is the cytosolic catalase induced by peroxisome proliferators in mouse liver on its way to the peroxisomes?
Topics: Animals; Catalase; Clofibrate; Cytosol; Enzyme Induction; Liver; Male; Mice; Mice, Inbred C57BL; Microbodies; Nafenopin; Pyrimidines | 1992 |
Induction of the major integral membrane protein of mouse liver peroxisomes by peroxisome proliferators.
Topics: Amino Acid Sequence; Animals; Anticholesteremic Agents; Blotting, Northern; Catalase; Cell Nucleus; Clofibrate; Electrophoresis, Polyacrylamide Gel; Female; Intracellular Membranes; Liver; Membrane Proteins; Mice; Mice, Inbred Strains; Microbodies; Molecular Sequence Data; Pyrimidines; RNA, Messenger; Transcription, Genetic | 1992 |
Involvement of calmodulin- and protein kinase C-related mechanism in an induction process of peroxisomal fatty acid oxidation-related enzymes by hypolipidemic peroxisome proliferators.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bezafibrate; Body Weight; Calmodulin; Catalase; Cells, Cultured; Clofibrate; Diethylhexyl Phthalate; Electrophoresis, Polyacrylamide Gel; Isoquinolines; Kinetics; Liver; Male; Membrane Proteins; Microbodies; Molecular Weight; Organ Size; Oxidation-Reduction; Piperazines; Protein Kinase C; Pyrimidines; Rats; Rats, Inbred Strains; Reference Values; Trifluoperazine | 1992 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Mice; Proteins; Pyrimidines | 1991 |
Alterations in the integrity of peroxisomal membranes in livers of mice treated with peroxisome proliferators.
Topics: Animals; Catalase; Clofibrate; Diethylhexyl Phthalate; Female; Mice; Microbodies; Mitochondria, Liver; Pyrimidines; Sonication | 1990 |
Effects of dietary treatment with clofibrate, nafenopin or WY-14.643 on mitochondria and DNA in mouse liver.
Topics: Animals; Anticholesteremic Agents; Cell Nucleus; Clofibrate; DNA; Enzymes; Liver; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Mitochondria, Liver; Nafenopin; Propionates; Pyrimidines; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Effect of peroxisome proliferators on intrachromosomal and interchromosomal recombination in yeast.
Topics: Anticholesteremic Agents; Chromosomes, Fungal; Clofibrate; Hypolipidemic Agents; Microbodies; Pyrimidines; Recombination, Genetic; Saccharomyces cerevisiae | 1990 |
Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.
Topics: Antibodies, Monoclonal; Asialoglycoprotein Receptor; Blotting, Western; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; ErbB Receptors; Fibric Acids; Fluorescent Antibody Technique; Isoelectric Point; Liver; Membrane Glycoproteins; Microbodies; Pyrimidines; Receptors, Immunologic; Sialoglycoproteins | 1990 |
Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Diethylnitrosamine; Drug Administration Schedule; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Immunologic Techniques; Liver; Microbodies; Pyrimidines; Rats; Time Factors | 1986 |
Changes to the integral membrane protein composition of mouse liver peroxisomes in response to the peroxisome proliferators clofibrate, Wy-14,643 and di(2-ethyl-hexyl)phthalate.
Topics: Animals; Antineoplastic Agents; Catalase; Clofibrate; Diethylhexyl Phthalate; Liver; Membrane Proteins; Mice; Microbodies; Oxidation-Reduction; Phthalic Acids; Pyrimidines | 1988 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; DNA; Fibric Acids; Hypolipidemic Agents; In Vitro Techniques; Liver; Liver Neoplasms; Male; Microbodies; Phosphorus Radioisotopes; Pyrimidines; Rats | 1985 |
A potent antihypercholesterolemic agent: (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio) acetic acid (Wy-14643).
Topics: Animals; Anticholesteremic Agents; Clofibrate; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Pyrimidines; Rats; Xylenes | 1974 |
Clofibrate, pirinixil (BR 931) and WY-14,643 do not affect body cholesterol in Sprague-Dawley rats.
Topics: Animals; Anticholesteremic Agents; Aorta; Cholesterol; Cholesterol, Dietary; Clofibrate; Drug Evaluation, Preclinical; Intestinal Mucosa; Kidney; Liver; Lung; Male; Myocardium; Pyrimidines; Rats; Spleen; Thioacetamide | 1980 |
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Topics: Animals; Base Sequence; Clofibrate; DNA, Complementary; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbodies; Microscopy, Electron; Molecular Sequence Data; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA; Transcription Factors | 1995 |
Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterations.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acyl-CoA Oxidase; Animals; Clofibrate; Deoxyguanosine; DNA, Mitochondrial; Male; Microbodies; Mitochondria, Liver; Oxidoreductases; Pyrimidines; Rats; Rats, Inbred F344 | 1995 |
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.
Topics: Acyl-CoA Oxidase; Amino Acid Sequence; Animals; Base Sequence; Chloramphenicol O-Acetyltransferase; Chromosome Mapping; Chromosomes, Human, Pair 22; Clofibrate; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Gene Library; Genetic Linkage; Humans; Lod Score; Mice; Microbodies; Mixed Function Oxygenases; Molecular Sequence Data; Nafenopin; Oligodeoxyribonucleotides; Oxidoreductases; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic; Pyrimidines; Rabbits; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Thymidine Kinase; Transcription Factors | 1993 |
Suppression of clofibrate-induction of peroxisomal and microsomal fatty acid-oxidizing enzymes by growth hormone and thyroid hormone in primary cultures of rat hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids; Female; Growth Hormone; Liver; Male; Microbodies; Microsomes; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Pyrimidines; Rats; Rats, Sprague-Dawley; Triiodothyronine | 1995 |
Diverse mechanisms of calcium mobilization by peroxisome proliferators in rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Antifungal Agents; Bezafibrate; Calcium; Clofibrate; Homeostasis; Imidazoles; In Vitro Techniques; Liver; Male; Microbodies; Pyrimidines; Rats; Rats, Wistar | 1995 |
Clofibrate and other peroxisomal proliferating agents relatively specifically inhibit synthesis of ethanolamine phosphoglycerides in cultured human fibroblasts.
Topics: Cells, Cultured; Choline; Clofibrate; Diethylhexyl Phthalate; Ethanolamine; Ethanolamines; Fatty Alcohols; Humans; Linolenic Acids; Microbodies; Phosphatidylethanolamines; Plasmalogens; Pyrimidines | 1994 |
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Microbodies; Pyrimidines; Rats; Rats, Inbred F344 | 1994 |
Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival.
Topics: 3T3 Cells; 5,8,11,14-Eicosatetraynoic Acid; Adipose Tissue; Animals; Apoptosis; Cell Survival; Clofibrate; Culture Media; Mice; Microbodies; Phenotype; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Signal Transduction; Stem Cells; Transcription Factors; Tretinoin | 1994 |
Ability of peroxisome proliferators to induce cell transformation, chromosome aberrations and peroxisome proliferation in cultured Syrian hamster embryo cells.
Topics: Animals; Benzidines; Cell Transformation, Neoplastic; Chromosome Aberrations; Clofibrate; Cricetinae; Diethylhexyl Phthalate; Mesocricetus; Microbodies; Pyrimidines | 1993 |
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
Topics: Acetophenones; Animals; Anticholesteremic Agents; Cell Line; Chlorocebus aethiops; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Gene Expression Regulation; Kidney; Liver; Male; Mammals; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Microbodies; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Tetrazoles; Transcription Factors; Transcriptional Activation; Transfection | 1996 |
Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Topics: Animals; Bezafibrate; Carcinogens; Cell Cycle; Cell Line; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Mice; Microbodies; Pyrimidines; Signal Transduction; Time Factors; Transcriptional Activation | 1996 |
Targeted disruption of the peroxisome proliferator-activated receptor alpha gene, PPAR alpha.
Topics: Animals; Carcinogens; Clofibrate; Fatty Acids; Hypolipidemic Agents; Mice; Mice, Knockout; Microbodies; Mutagenesis, Insertional; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 1996 |
PPAR alpha mediates peroxisome proliferator-induced transcriptional repression of nonperoxisomal gene expression in mouse.
Topics: Alpha-Globulins; Animals; Clofibrate; Diethylhexyl Phthalate; Gene Expression Regulation; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Microbodies; Nuclear Proteins; Prealbumin; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Species Specificity; Time Factors; Transcription Factors; Transcription, Genetic | 1997 |
The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis.
Topics: Animals; Clofenapate; Clofibrate; DNA Replication; Glucocorticoids; Growth Substances; Liver; Male; Microbodies; Mitogens; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Sulfides; Transcription Factors | 1998 |
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.
Topics: Adipates; Adipose Tissue; Animals; Base Sequence; CD36 Antigens; Clofibrate; Diethylhexyl Phthalate; DNA Primers; Gene Expression Regulation; Liver; Liver Neoplasms, Experimental; Male; Membrane Glycoproteins; Mice; Microbodies; Organic Anion Transporters; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 1998 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.
Topics: Animals; Bezafibrate; Carrier Proteins; Clofibrate; DNA-Binding Proteins; Eating; Fatty Acids, Nonesterified; Female; Gene Expression Regulation, Developmental; Hypolipidemic Agents; Ion Channels; Leptin; Male; Mice; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Development; Muscle, Skeletal; Peroxisome Proliferators; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Uncoupling Protein 3 | 1999 |
Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Carnitine O-Palmitoyltransferase; Clofibrate; Creatinine; Enzymes; Epoxy Compounds; Ischemia; Kidney; Male; Mice; Mice, Knockout; Necrosis; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Renal Circulation; Reperfusion Injury; Transcription Factors | 2000 |
Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes.
Topics: Alginates; Animals; Cartilage, Articular; Chondrocytes; Clofibrate; Endothelial Growth Factors; Glucuronic Acid; Hexuronic Acids; Interleukin-1; Ligands; Male; Melatonin; Nuclear Receptor Subfamily 1, Group F, Member 1; Polymerase Chain Reaction; Pyrimidines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Retinoic Acid; RNA, Messenger; Trans-Activators; Transcription Factors | 2000 |
Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.
Topics: Animals; Base Sequence; Binding Sites; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dietary Fats, Unsaturated; DNA Primers; Fatty Acids, Unsaturated; Fish Oils; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mixed Function Oxygenases; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2000 |
Clofibrate inhibits membrane trafficking to the Golgi complex and induces its retrograde movement to the endoplasmic reticulum.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cells, Cultured; Clofibrate; Cytochrome P-450 Enzyme System; Diethylhexyl Phthalate; Endoplasmic Reticulum; Fatty Acids; Fluorescent Antibody Technique; Golgi Apparatus; Hypolipidemic Agents; Liver; Mannosidases; Membrane Glycoproteins; Microtubules; Nocodazole; Peroxisome Proliferators; Peroxisomes; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Viral Envelope Proteins | 1999 |
PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.
Topics: Acyltransferases; Animals; Clofibrate; Esterification; Estradiol; Female; Mice; Mice, Knockout; Microsomes, Liver; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Testosterone; Transcription Factors | 2001 |
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
Topics: Adjuvants, Immunologic; Administration, Topical; Animals; Clofibrate; Dermatitis, Allergic Contact; Drug Eruptions; Female; Interleukin-1; Irritants; Linoleic Acid; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Oxazolone; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha | 2002 |
Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, WY-14,643, increased transcription of myosin light chain-2 in cardiomyocytes.
Topics: Animals; Body Weight; Cardiac Myosins; Cell Line; Clofibrate; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Heart; Immunohistochemistry; Male; Myocardium; Myosin Light Chains; Organ Size; Peroxisome Proliferators; Proteins; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcription, Genetic | 2001 |
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
Topics: Acetylcysteine; Animals; Apolipoprotein B-100; Apolipoprotein B-48; Apolipoproteins B; Cell Line; Cells, Cultured; Clofibrate; Cytosol; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Female; Immunoblotting; Oleic Acid; Palmitic Acid; Protein Binding; Protein Biosynthesis; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Triglycerides; Tumor Cells, Cultured | 2002 |
Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages.
Topics: Anti-Inflammatory Agents; Astrocytes; Brain; Cells, Cultured; Clofibrate; Cyclooxygenase 2; Cytokines; Gene Silencing; Humans; Isoenzymes; Membrane Proteins; Microglia; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors | 2002 |
Gene expression analysis reveals chemical-specific profiles.
Topics: Animals; Clofibrate; Computational Biology; DNA, Complementary; Gemfibrozil; Gene Expression; Gene Expression Profiling; Genomics; Liver; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Peroxisome Proliferators; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2002 |
Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Topics: Animals; Cell Culture Techniques; Cell Death; Chromans; Clofibrate; Cyclooxygenase 2; Dinoprostone; Electrophoretic Mobility Shift Assay; Escherichia coli; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lipopolysaccharides; Mice; Mice, Inbred ICR; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxisome Proliferators; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine CCL2; Clofibrate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ligands; Male; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Pioglitazone; Prostaglandin D2; Prostaglandins A; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size.
Topics: Animals; Cardiotonic Agents; Clofibrate; Disease Models, Animal; Heart; Hemodynamics; Ligands; Male; Myocardial Infarction; Myocardium; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231.
Topics: Breast Neoplasms; Cell Division; Clofibrate; Female; Gene Expression Regulation, Neoplastic; Humans; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2002 |
Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.
Topics: Animals; Clofibrate; Gene Expression; Intercellular Adhesion Molecule-1; Kidney; Male; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; RNA, Messenger; Transcription Factors | 2002 |
PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells.
Topics: Cells, Cultured; Clofibrate; Dose-Response Relationship, Drug; Genetic Vectors; Glomerular Mesangium; Humans; Hydrogen Peroxide; Immunohistochemistry; Ligands; Luciferases; Mitogen-Activated Protein Kinases; Plasmids; Promoter Regions, Genetic; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transduction, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Topics: Aging; Animals; Apoptosis; Carcinogens; Cell Count; Cholesterol; Clofibrate; Hepatocytes; Hepatomegaly; Hypolipidemic Agents; Liver; Liver Neoplasms, Experimental; Male; Nuclease Protection Assays; Oxidation-Reduction; Peroxisomes; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; RNA; Transcription Factors; Triglycerides | 2003 |
Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.
Topics: Animals; Cell Line, Transformed; Chromans; Clofibrate; Dexamethasone; Gene Expression; Humans; Interleukin-1; Lacrimal Apparatus; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; PPAR alpha; PPAR gamma; Pterins; Pyrimidines; Rabbits; Thiazolidinediones; Troglitazone | 2003 |
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer.
Topics: Acids, Acyclic; Animals; Bezafibrate; Binding Sites; Cell Line, Tumor; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Dimerization; DNA-Binding Proteins; Gemfibrozil; Gene Expression Regulation; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hydroxycholesterols; Ligands; Liver X Receptors; Nuclear Proteins; Orphan Nuclear Receptors; Promoter Regions, Genetic; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; Transcription Factors | 2004 |
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Carnitine Acyltransferases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Hepatocytes; Humans; Male; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Wistar; Response Elements; Species Specificity; Transfection | 2004 |
The human semaphorin 6B gene is down regulated by PPARs.
Topics: 5' Flanking Region; Base Sequence; Binding Sites; Binding, Competitive; Cell Line, Tumor; Clofibrate; DNA-Binding Proteins; Down-Regulation; Electrophoretic Mobility Shift Assay; Genome Components; Glioblastoma; Humans; Immunoprecipitation; Molecular Sequence Data; Peroxisome Proliferator-Activated Receptors; Protein Binding; Pyrimidines; Response Elements; Retinoid X Receptor alpha; RNA, Messenger; Semaphorins | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Topics: Adenoma; Alkylating Agents; alpha-Macroglobulins; Animals; Anticholesteremic Agents; Biomarkers, Tumor; Clofibrate; Diethylnitrosamine; Disease Progression; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Immunohistochemistry; In Situ Hybridization; Lasers; Liver; Liver Neoplasms; Male; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Time Factors; Up-Regulation | 2004 |
Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.
Topics: Alkaline Phosphatase; Binding Sites; Binding, Competitive; Cell Line, Tumor; Cells, Cultured; Clofibrate; DNA; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Hepatocytes; Humans; Ligands; Mutation; PPAR alpha; Pregnane X Receptor; Promoter Regions, Genetic; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transfection | 2006 |
Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.
Topics: Acyl-CoA Oxidase; Animals; Anticholesteremic Agents; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cholesterol; Cholesterol, VLDL; Clofibrate; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Hydroxymethylglutaryl CoA Reductases; Intracellular Signaling Peptides and Proteins; Liver; Male; Membrane Proteins; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Triglycerides | 2007 |
Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators.
Topics: Alanine Transaminase; Animals; Cells, Cultured; Clofibrate; Cluster Analysis; Databases, Factual; Gemfibrozil; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Liver; Male; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; PPAR alpha; Principal Component Analysis; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides | 2006 |
Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.
Topics: Animals; Caspase 3; Cell Line; Cell Survival; Clofibrate; DNA Fragmentation; Hypoglycemic Agents; Hypolipidemic Agents; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; LLC-PK1 Cells; Mice; Opossums; Peroxisome Proliferators; Pioglitazone; PPAR alpha; PPAR gamma; Pyrimidines; Swine; Thiazolidinediones | 2007 |
Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.
Topics: Angiotensin II; Animals; Cardiovascular Agents; Clofibrate; Fenofibrate; Hemodynamics; Male; Models, Animal; Nitric Oxide; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2008 |
Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha.
Topics: Animals; Clofibrate; Fasting; Fatty Acids; Hypolipidemic Agents; Ketone Bodies; Male; Mice; Monocarboxylic Acid Transporters; Organ Specificity; Oxidation-Reduction; Peroxisome Proliferators; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Symporters; Up-Regulation | 2008 |
Effects of peroxisome proliferator-activated receptor alpha (PPARalpha) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Clofibrate; Elongation Factor 2 Kinase; Eukaryotic Initiation Factors; Flavonoids; Leucine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multienzyme Complexes; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; PPAR alpha; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus | 2008 |
Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
Topics: Acids; Animals; Animals, Newborn; Anticholesteremic Agents; Clofibrate; Epidermis; Female; Homeostasis; Lipid Metabolism; Permeability; Phospholipases A2, Secretory; PPAR alpha; PPAR gamma; PPAR-beta; Pregnancy; Pyrimidines; Rats; Rats, Sprague-Dawley; Skin Diseases | 2009 |
Glucans from the Caripia montagnei mushroom present anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Ascitic Fluid; Basidiomycota; Caprylates; Carrageenan; Cell Movement; Clofibrate; Complex Mixtures; Cytokines; Edema; Fluorocarbons; Glucans; Leukocytes; Magnetic Resonance Spectroscopy; Male; Mice; Nitric Oxide; Peritonitis; Pyrimidines; Rats; Rats, Wistar; Thioglycolates | 2010 |
26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Topics: Adenoma, Liver Cell; Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Clofibrate; Diethylhexyl Phthalate; Disease Models, Animal; Female; Genes, ras; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Transgenic; Phthalic Acids; Pyrimidines; Time Factors | 2011 |
Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.
Topics: Animals; Clofibrate; Female; Genotype; Liver; Male; Mice; Mice, Knockout; Organ Size; Peroxisome Proliferators; PPAR alpha; Pregnancy; Prenatal Exposure Delayed Effects; Pyrimidines | 2010 |
Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery.
Topics: Anilides; Animals; Anticholesteremic Agents; Benzamides; Calcium; Clofibrate; Colon; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Guanylate Cyclase; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Nitric Oxide Synthase; Oxazoles; Potassium Channel Blockers; PPAR alpha; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Sodium Channel Blockers; Soluble Guanylyl Cyclase | 2011 |
Organotypic modeling of human keratinocyte response to peroxisome proliferators.
Topics: Blotting, Northern; Blotting, Western; Cell Differentiation; Cells, Cultured; Clofibrate; Electrophoresis; Filaggrin Proteins; Humans; Immunohistochemistry; Keratinocytes; Microscopy, Fluorescence; Peroxisome Proliferators; Pyrimidines | 2012 |
Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.
Topics: Animals; Anticholesteremic Agents; Clofibrate; Humans; Hyperlipidemias; Mice; Mice, Knockout; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; PPAR alpha; Proteasome Endopeptidase Complex; Proteolysis; Pyrimidines; Rats; Signal Transduction; Transcription, Genetic; Ubiquitin; Ubiquitination; Up-Regulation | 2013 |
Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
Topics: Animals; Cell Differentiation; Clofibrate; Cyclin D; Cyclin-Dependent Kinase 4; G1 Phase Cell Cycle Checkpoints; Mesenchymal Stem Cells; Mice; Myocytes, Smooth Muscle; Phenotype; Phosphorylation; PPAR alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; Serum Response Factor; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2013 |
PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.
Topics: Animals; Clofibrate; Dimethyl Sulfoxide; Gene Expression; Hep G2 Cells; Humans; Liver; Mice; PPAR alpha; Pyrimidines; Stem Cells | 2013 |
Peroxisome proliferator-activated receptor α agonist-induced histidine decarboxylase gene expression in the rat and mouse liver.
Topics: Animals; Cell Proliferation; Cells, Cultured; Clofibrate; Databases, Genetic; Fenofibrate; Gene Expression; Hepatocytes; Histidine Decarboxylase; Hypertrophy; Liver; Male; Mice; Mice, Inbred C57BL; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Species Specificity | 2020 |