pirinixic acid has been researched along with ciprofibrate in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 14 (43.75) | 18.2507 |
| 2000's | 8 (25.00) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Cannon, JR; Eacho, PI | 1 |
| Gemmell, MA; Giometti, CS; Lalwani, ND; Reddy, JK; Taylor, J; Tollaksen, SL | 2 |
| Danna, TF; Randerath, E; Randerath, K; Rao, MS; Reddy, JK; Reddy, R | 1 |
| Bartles, JR; Fayos, BE; Isoye, ST; Khuon, S; Lin, XH; Nehme, CL; Rao, MS; Reddy, JK; Zhang, LQ | 1 |
| Makino, T; Nemali, MR; Pitot, HC; Rao, MS; Reddy, JK; Scarpelli, DG; Usuda, N | 1 |
| Beer, D; Coloma, J; Glauert, HP; Goldsworthy, TL; Pitot, HC; Rao, MS; Schwarz, M; Xu, YD | 1 |
| Ito, N; Rao, MS; Reddy, JK; Subbarao, V; Tatematsu, M | 1 |
| Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Earley, K; Goel, SK; Gupta, RC; Reddy, JK; Singh, B | 1 |
| Jannin, B; Latruffe, N; Passilly, P | 1 |
| Alvares, K; Capone, JP; Dadras, SS; Fan, C; Iannaccone, PM; Rachubinski, RA; Rao, MS; Reddy, JK; Subramani, S; Yeldandi, AV | 1 |
| Bartles, JR; Fayos, BE | 1 |
| Beamand, JA; Cunninghame, ME; Lake, BG; Price, RJ | 1 |
| Beamand, JA; Charzat, C; Lake, BG; Price, RJ; Renwick, AB; Tredger, JM | 1 |
| Galloway, SM; Johnson, TE; Ledwith, BJ; Manam, S; Nichols, WW; Pauley, CJ; Wagner, LK | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Hashimoto, T; Maeda, N; Pan, J; Pulikuri, S; Qi, C; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV; Zhu, Y | 1 |
| Wallace, KB; Zhou, S | 1 |
| Cunninghame, ME; Lake, BG; Price, RJ; Rumsby, PC | 1 |
| Duez, H; Gervois, PP; Kuipers, F; Post, SM; Princen, HM; Staels, B | 1 |
| Bakke, I; Hammer, TA; Sandvik, AK; Waldum, HL | 1 |
| Bloks, VW; Havinga, R; Jansen, PL; Kok, T; Kuipers, F; Staels, B; Wolters, H | 1 |
| Ammerschlaeger, M; Beigel, J; Klein, KU; Mueller, SO | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Bournot, P; Chevillard, G; Duclos, S; Le Jossic-Corcos, C; Martin, P; Pineau, T; Ramirez, LC; Zaghini, I | 1 |
| Hannig, M; Piper, HM; Sauer, H; Sharifpanah, F; Wartenberg, M | 1 |
| Brandsch, C; König, B; Schutkowski, A; Stangl, GI; Wege, N; Weiwad, M | 1 |
32 other study(ies) available for pirinixic acid and ciprofibrate
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver.
Topics: Acetophenones; Animals; Bezafibrate; Carrier Proteins; Clofibric Acid; Electrophoresis, Polyacrylamide Gel; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fibric Acids; Male; Microbodies; Neoplasm Proteins; Nerve Tissue Proteins; Oleic Acid; Oleic Acids; Pyrimidines; Rats; Rats, Inbred F344; SRS-A; Tetrazoles | 1991 |
A comparative study of the effects of clofibrate, ciprofibrate, WY-14,643, and di-(2-ethylhexyl)-phthalate on liver protein expression in mice.
Topics: Animals; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Female; Fibric Acids; Hypolipidemic Agents; Liver; Male; Membrane Proteins; Mice; Microbodies; Pyrimidines | 1991 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Mice; Proteins; Pyrimidines | 1991 |
Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling.
Topics: Affinity Labels; Animals; Clofibric Acid; DNA Damage; DNA, Neoplasm; Fibric Acids; Hypolipidemic Agents; Liver; Liver Neoplasms; Male; Microbodies; Mutagens; Pyrimidines; Rats; Rats, Inbred F344 | 1991 |
Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.
Topics: Antibodies, Monoclonal; Asialoglycoprotein Receptor; Blotting, Western; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; ErbB Receptors; Fibric Acids; Fluorescent Antibody Technique; Isoelectric Point; Liver; Membrane Glycoproteins; Microbodies; Pyrimidines; Receptors, Immunologic; Sialoglycoproteins | 1990 |
Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.
Topics: alpha-Fetoproteins; Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Liver Neoplasms, Experimental; Microbodies; Neoplasm Transplantation; Pyrimidines; Rats; RNA, Messenger | 1988 |
Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Diethylnitrosamine; Drug Administration Schedule; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Immunologic Techniques; Liver; Microbodies; Pyrimidines; Rats; Time Factors | 1986 |
Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.
Topics: Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Placenta; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; DNA; Fibric Acids; Hypolipidemic Agents; In Vitro Techniques; Liver; Liver Neoplasms; Male; Microbodies; Phosphorus Radioisotopes; Pyrimidines; Rats | 1985 |
Influence of peroxisome proliferators on phosphoprotein levels in human and rat hepatic-derived cell lines.
Topics: Animals; Cell Line; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Liver; Microbodies; Oxidoreductases; Phosphoproteins; Phosphorylation; Pyrimidines; Rats | 1995 |
An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Clofibric Acid; Diethylhexyl Phthalate; Enoyl-CoA Hydratase; Fibric Acids; Genes, Reporter; Liver; Luciferases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microbodies; Nafenopin; Pyrimidines | 1994 |
Regulation of hepatocytic glycoprotein sialylation and sialyltransferases by peroxisome proliferators.
Topics: Animals; Anticholesteremic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; beta-Galactosidase; beta-Galactoside alpha-2,3-Sialyltransferase; Blotting, Western; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Polyacrylamide Gel; Fibric Acids; Glycoproteins; Hypolipidemic Agents; Kinetics; Liver; Male; Membrane Glycoproteins; Microbodies; Molecular Weight; Pyrimidines; Rats; Rats, Inbred F344; RNA, Messenger; Sialoglycoproteins; Sialyltransferases | 1994 |
Culture of precision-cut liver slices: effect of some peroxisome proliferators.
Topics: Animals; Carnitine O-Acetyltransferase; Clofibric Acid; Culture Media; Culture Techniques; Fibric Acids; Liver; Male; Microbodies; Microscopy, Electron; Nafenopin; Oxidation-Reduction; Palmitoyl Coenzyme A; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Humans; Isoenzymes; Liver; Male; Microbodies; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley | 1996 |
Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Topics: Animals; Bezafibrate; Carcinogens; Cell Cycle; Cell Line; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Mice; Microbodies; Pyrimidines; Signal Transduction; Time Factors; Transcriptional Activation | 1996 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.
Topics: Animals; Cell Division; Clofibric Acid; DNA Primers; DNA-Binding Proteins; Exons; Fibric Acids; Gene Expression Regulation; Genotype; Histone Acetyltransferases; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Microbodies; Nuclear Receptor Coactivator 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 1999 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig.
Topics: Animals; Cell Division; Clofenapate; Clofibric Acid; Cricetinae; DNA; Fibric Acids; Gene Expression; Guinea Pigs; Liver; Male; Mesocricetus; Molecular Structure; Organ Size; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 2; Species Specificity; Transforming Growth Factor beta | 2000 |
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Clofibric Acid; Cytochrome P-450 Enzyme System; Down-Regulation; Fibric Acids; Hepatocytes; Hypolipidemic Agents; Mice; Mice, Knockout; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Steroid Hydroxylases; Transcription Factors; Transcription, Genetic | 2001 |
PPAR alpha stimulates the rat gastrin-producing cell.
Topics: Animals; Chromans; Clofibric Acid; Female; Fibric Acids; Gastric Mucosa; Gastrins; Ligands; Parietal Cells, Gastric; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bile; Carrier Proteins; Cells, Cultured; Clofibric Acid; Fibric Acids; Hepatocytes; Lipid Metabolism; Lipoproteins; Liver; Male; Membrane Transport Proteins; Mice; Mice, Mutant Strains; Organ Size; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Symporters; Taurochenodeoxycholic Acid; Transcription Factors | 2003 |
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Carnitine Acyltransferases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Hepatocytes; Humans; Male; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Wistar; Response Elements; Species Specificity; Transfection | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.
Topics: Acetates; Animals; Bile Acids and Salts; Carbon Isotopes; Carboxy-Lyases; CCAAT-Enhancer-Binding Proteins; Cell Division; Cholesterol; Clofibric Acid; DNA-Binding Proteins; Fibric Acids; Hepatocytes; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Up-Regulation | 2004 |
Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Topics: Animals; Butyrates; Cell Differentiation; Cells, Cultured; Clofibric Acid; Embryonic Stem Cells; Enzyme Inhibitors; Fibric Acids; Free Radical Scavengers; Gene Expression; Gene Expression Regulation, Developmental; Heart; Immunohistochemistry; Indoles; Mice; Myocytes, Cardiac; NADPH Oxidases; Peroxisome Proliferators; Phenylurea Compounds; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model.
Topics: Animals; Cell Line; Fasting; Fatty Acids, Nonesterified; Fibric Acids; Gene Expression Regulation; Humans; Male; Mice; Mice, Knockout; Mice, Transgenic; Neurokinin B; Pituitary Gland; PPAR alpha; Pyrimidines; Retinoid X Receptor alpha; RNA, Messenger; Thyroid Hormone Receptors beta; Thyrotrophs; Thyrotropin, beta Subunit; Thyroxine; Triiodothyronine | 2013 |