pirfenidone has been researched along with hydroxyproline in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Giri, SN; Hyde, DM; Iyer, SN; Margolin, SB; Schiedt, MJ; Wild, JS | 1 |
| Kehrer, JP; Margolin, SB | 1 |
| Giri, S; Mansoor, JK; Schelegle, ES | 1 |
| Fukagawa, M; Hata, S; Iwasaki, Y; Kuroda, T; Kurokawa, K; Margolin, SB; Nemoto, M; Shimizu, F; Shimizu, T; Shirai, K; Yamauchi, S | 1 |
| Fukagawa, M; Hata, S; Kuroda, T; Kurokawa, K; Margolin, SB; Shimizu, T | 1 |
| Giri, SN; Gurujeyalakshmi, G; Iyer, SN | 1 |
| Chen, AT; Giri, S; Mansoor, JK; Schelegle, ES | 1 |
| Enjoji, M; Iwamoto, H; Kato, M; Nakamuta, M; Nakashima, Y; Nawata, H; Sugimoto, R; Tada, S | 1 |
| Armendariz-Borunda, J; Garcia, J; García, L; Grijalva, G; Hernández, I; Margolin, S; Muriel, P; Salazar, A; Sandoval, A; Vera, J | 1 |
| Brien, JF; Card, JW; Margolin, SB; Massey, TE; Racz, WJ | 1 |
| Abe, K; Fujii, T; Hayashi, T; Ishii, H; Kadota, J; Kakugawa, T; Kohno, S; Miyazaki, M; Mukae, H; Oku, H | 1 |
| Ammar, YA; Bayomi, AH; El-Sehrawi, HM; Ismail, MM; Noaman, E; Shawer, TZ | 1 |
| Gu, L; Guo, ZJ; Tian, XL; Yao, W; Zhu, YJ | 1 |
| Choi, YH; Jou, I; Kim, H; Kim, SJ; Kook, KH; Lee, SY; Park, SJ | 1 |
| Chen, JQ; Chen, RP; Feng, LF; Jia, ZY; Jiang, ZQ; Ju, L; Ma, Z; Zhang, X; Zhu, LJ | 1 |
| Kanehira, Y; Tada, H; Togami, K | 1 |
| Gao, Y; Han, R; He, J; Kang, L; Li, C; Li, Y; Tian, J; Wang, J | 1 |
| Kamali, Y; Mandegary, A; Nabipour, F; Pourgholamhosein, F; Rasooli, R | 1 |
| Ghazi-Khansari, M; Heidari, MR; Iranpour, M; Mandegary, A; Pourgholamhossein, F; Pourgholi, L; Pournamdari, M; Poursalehi, HR; Rasooli, R; Samareh-Fekri, M | 1 |
| Dorati, R; Fourcaudot, AB; Leung, KP; Medina, JL; Sebastian, EA | 1 |
| Bo, C; Jia, Q; Li, M; Tang, Q; Xing, C; Zhang, Z | 1 |
21 other study(ies) available for pirfenidone and hydroxyproline
| Article | Year |
|---|---|
Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters.
Topics: Analysis of Variance; Animals; Bleomycin; Body Weight; Cricetinae; Diet; Hydroxyproline; Lipid Peroxidation; Lung; Male; Mesocricetus; Peroxidase; Procollagen-Proline Dioxygenase; Pulmonary Fibrosis; Pyridones; Superoxide Dismutase | 1995 |
Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclophosphamide; Hydroxyproline; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Pulmonary Fibrosis; Pyridones | 1997 |
Pirfenidone attenuates bleomycin-induced changes in pulmonary functions in hamsters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Body Weight; Cardiovascular System; Cricetinae; Hydroxyproline; Lung; Male; Pulmonary Fibrosis; Pyridones; Respiration; Respiratory Function Tests | 1997 |
Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Body Weight; Collagen; Creatinine; Fibrosis; Hydroxyproline; Kidney; Male; Nephrectomy; Pyridones; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta | 1997 |
Pirfenidone improves renal function and fibrosis in the post-obstructed kidney.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Collagen; Disease Models, Animal; Fibrosis; Gelatinases; Hydroxyproline; Inulin; Kidney Cortex; Kidney Function Tests; Ligation; Male; Matrix Metalloproteinase 2; Metalloendopeptidases; Pyridones; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Ribosomal, 18S; RNA, Ribosomal, 28S; Transforming Growth Factor beta; Ureter; Ureteral Obstruction | 1998 |
Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Cricetinae; Gene Expression Regulation; Hydroxyproline; In Situ Hybridization; In Vitro Techniques; Kinetics; Lipid Peroxidation; Lung; Male; Malondialdehyde; Mesocricetus; Procollagen; Procollagen-Proline Dioxygenase; Pulmonary Fibrosis; Pyridones; RNA, Messenger; Transcription, Genetic | 1999 |
Effect of diet-ingested pirfenidone on pulmonary function, cardiovasculature and blood gas measurements in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; Blood Pressure; Cardiac Output; Cardiovascular System; Expiratory Reserve Volume; Heart Rate; Hydroxyproline; Lung; Male; Pulmonary Gas Exchange; Pyridones; Rats; Rats, Wistar; Residual Volume; Respiration | 1999 |
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Blotting, Northern; Body Weight; Collagen; Dimethylnitrosamine; Hydroxyproline; Liver Cirrhosis; Male; Pyridones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2001 |
Pirfenidone effectively reverses experimental liver fibrosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Bilirubin; Carbon Tetrachloride; Hydroxyproline; Ligation; Liver; Liver Cirrhosis; Liver Regeneration; Male; Matrix Metalloproteinase 2; Prothrombin; Pyridones; Rats; Rats, Wistar | 2002 |
Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.
Topics: Acute Disease; Amiodarone; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Cricetinae; Disease Models, Animal; Hydroxyproline; Male; Membrane Potentials; Mitochondria; Oxygen Consumption; Pulmonary Fibrosis; Pyridones; RNA, Messenger; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Bleomycin; Disease Models, Animal; HSP70 Heat-Shock Proteins; Hydroxyproline; Immunohistochemistry; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Probability; Pulmonary Fibrosis; Pyridones; Random Allocation; Reference Values; Sensitivity and Specificity | 2004 |
Novel pirfenidone analogues: synthesis of pyridin-2-ones for the treatment of pulmonary fibrosis.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Bleomycin; Bronchoalveolar Lavage Fluid; Creatinine; Dihydropyridines; Disease Models, Animal; Hydroxyproline; Intubation, Intratracheal; L-Lactate Dehydrogenase; Lung; Male; Molecular Structure; Pulmonary Fibrosis; Pyridones; Rats; Time Factors; Urea | 2006 |
Low dose pirfenidone suppresses transforming growth factor beta-1 and tissue inhibitor of metalloproteinase-1, and protects rats from lung fibrosis induced by bleomycina.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Dose-Response Relationship, Drug; Hydroxyproline; Lung; Male; Matrix Metalloproteinase 13; Pulmonary Fibrosis; Pyridones; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2006 |
Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Culture Techniques; Cell Survival; Collagen; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Graves Ophthalmopathy; Humans; Hydroxyproline; Intercellular Signaling Peptides and Proteins; Interleukin-1beta; Male; Middle Aged; Orbit; Pyridones; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Young Adult | 2010 |
[Pirfenidone diminishes SiO2 induced lung fibrosis in rats].
Topics: Animals; Hydroxyproline; Lung; Male; Pulmonary Fibrosis; Pyridones; Rats; Rats, Sprague-Dawley; Silicon Dioxide | 2010 |
Possible involvement of pirfenidone metabolites in the antifibrotic action of a therapy for idiopathic pulmonary fibrosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Collagen; Fibroblasts; Humans; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Lung; Pyridones; Transforming Growth Factor beta1 | 2013 |
Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Collagen Type I; Collagen Type III; Feedback, Physiological; Fibrosis; Hemodynamics; Hydroxyproline; Liver X Receptors; Male; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridones; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Signal Transduction; Systole; Ventricular Dysfunction | 2017 |
Combination Therapy with Pirfenidone plus Prednisolone Ameliorates Paraquat-Induced Pulmonary Fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Cytoprotection; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Regulation; Glucocorticoids; Hydroxyproline; Inflammation Mediators; Lung; Male; Matrix Metalloproteinase 2; Oxidative Stress; Paraquat; Prednisolone; Pulmonary Fibrosis; Pyridones; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2018 |
Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Bronchoalveolar Lavage Fluid; Fibrosis; Gene Expression; Gene Expression Profiling; Herbicides; Hydroxyproline; Lung; Lung Injury; Male; Mice; Organ Size; Oxidative Stress; Paraquat; Pneumonia; Pulmonary Fibrosis; Pyridones; Reactive Oxygen Species; Transforming Growth Factor beta1 | 2018 |
Pirfenidone Ointment Modulates the Burn Wound Bed in C57BL/6 Mice by Suppressing Inflammatory Responses.
Topics: Actins; Animals; Burns; Cicatrix; Cytokines; Hydroxyproline; Inflammation; Mice; Mice, Inbred C57BL; Pyridones | 2019 |
Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways.
Topics: Animals; Fibrosis; Hydroxyproline; Interleukin-18; Janus Kinase 2; Macrophages; Pneumonia; Pulmonary Fibrosis; Pyridones; Rats; RNA, Messenger; Signal Transduction; Silicosis; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Vimentin | 2022 |