pirarubicin has been researched along with cupric-chloride* in 1 studies
1 other study(ies) available for pirarubicin and cupric-chloride
| Article | Year |
|---|---|
Oxidative DNA Damage Induced by Pirarubicin, an Anthracycline Anticancer Agent, in the Presence of Copper(II).
One mechanism of the anticancer action of anthracyclines is believed to be oxidative DNA damage. Previously, we reported that doxorubicin induced oxidative DNA damage in the presence of Cu(II). However, the mechanism of pirarubicin-induced oxidative DNA damage has not been well clarified.. DNA damage by pirarubicin in the presence of Cu(II) was analyzed using pBR322 plasmid DNA. O. Pirarubicin induced DNA damage in the presence of Cu(II). Scavenger experiments suggest that reactive species are generated from H. These findings suggest that pirarubicin plus Cu(II) induces oxidative DNA damage in a similar manner to doxorubicin, and Cu(II)-mediated oxidative DNA damage may serve as a common mechanism for antitumor effects of anthracyclines. Topics: Antibiotics, Antineoplastic; Cations, Divalent; Copper; Cytochromes c; DNA Damage; DNA, Circular; Doxorubicin; Drug Synergism; Electrophoresis, Agar Gel; Humans; Molecular Structure; Oxidation-Reduction; Phenanthrolines; Plasmids; Reactive Oxygen Species; Superoxides | 2018 |