piperine has been researched along with myelin-oligodendrocyte-glycoprotein-(35-55)* in 1 studies
1 other study(ies) available for piperine and myelin-oligodendrocyte-glycoprotein-(35-55)
| Article | Year |
|---|---|
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.
Multiple sclerosis (MS) is the most popular chronic and debilitating inflammatory disease of the central nervous system (CNS) that remains incurable. Dihydroorotate dehydrogenase (DHODH) is critical to the activity of T lymphocytes and represents a potential therapeutic target for MS. Here we identify piperine, a bioactive constituent of black pepper, as a potent inhibitor of DHODH with an IC Topics: Alkaloids; Animals; Benzodioxoles; Biological Products; Blood-Brain Barrier; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Jurkat Cells; Mice, Inbred C57BL; Models, Molecular; Molecular Targeted Therapy; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Oxidoreductases Acting on CH-CH Group Donors; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Spleen | 2020 |