piperidines has been researched along with trichloroacetamide* in 1 studies
1 other study(ies) available for piperidines and trichloroacetamide
| Article | Year |
|---|---|
Palladium(II)-catalyzed enantioselective synthesis of 2-vinyl oxygen heterocycles.
2-Vinylchromanes (1), 2-vinyl-1,4-benzodioxanes (2), and 2,3-dihydro-2-vinyl-2H-1,4-benzoxazines (3) can be prepared in high yields (90-98%) and excellent enantiomeric purities (87-98% ee) by [COP-OAc](2)-catalyzed cyclization of phenolic (E)-allylic trichloroacetimidate precursors. Deuterium-labeling and computational experiments are consistent with these cyclization reactions taking place by an anti-oxypalladation/syn-deoxypalladation mechanism. 2-Vinylchromanes can also be prepared in good yields and high enantiomeric purities from analogous (E)-allylic acetate precursors, which constitutes the first report that acetate is a competent leaving group in COP-catalyzed enantioselective S(N)2' substitution reactions. Topics: Acetamides; Benzoxazines; Catalysis; Chloroacetates; Chromans; Computer Simulation; Cyclization; Deuterium; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Oxygen; Palladium; Piperidines; Staining and Labeling; Stereoisomerism; Trichloroacetic Acid; Vinyl Compounds | 2012 |