piperidines and tetralin

piperidines has been researched along with tetralin* in 2 studies

Other Studies

2 other study(ies) available for piperidines and tetralin

Article	Year
A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core. Bioorganic & medicinal chemistry letters, 2006, Apr-15, Volume: 16, Issue:8 The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC50s<20 nM in a B1 receptor functional assay. One of these compounds, 13g, shows modest oral bioavailability in rats. Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bradykinin B1 Receptor Antagonists; Inhibitory Concentration 50; Piperidines; Rats; Structure-Activity Relationship; Tetrahydronaphthalenes	2006
Morphine studies; the synthesis of a tetralin-piperidine fused-ring system. Journal of the American Chemical Society, 1949, Volume: 71, Issue:4 Topics: Morphine; Piperidines; Tetrahydronaphthalenes	1949

Article

Year

A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core.

Bioorganic & medicinal chemistry letters, 2006, Apr-15, Volume: 16, Issue:8

The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC50s<20 nM in a B1 receptor functional assay. One of these compounds, 13g, shows modest oral bioavailability in rats.

Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bradykinin B1 Receptor Antagonists; Inhibitory Concentration 50; Piperidines; Rats; Structure-Activity Relationship; Tetrahydronaphthalenes

2006

Morphine studies; the synthesis of a tetralin-piperidine fused-ring system.

Journal of the American Chemical Society, 1949, Volume: 71, Issue:4

Topics: Morphine; Piperidines; Tetrahydronaphthalenes

1949