piperidines and tetrachloroisophthalonitrile

To investigate the activity of niraparib in patients with germline-mutated. BRAVO was a randomized, open-label phase III trial. Eligible patients had g. After the pre-planned interim analysis, recruitment was halted on the basis of futility, noting a high degree of discordance between local and central PFS assessment in the PC arm that resulted in informative censoring. At the final analysis (median follow-up, 19.9 months), median centrally assessed PFS was 4.1 months in the niraparib arm (. Informative censoring in the control arm prevented accurate assessment of the trial hypothesis, although there was clear evidence of niraparib's activity in this patient population.

Topics: BCG Vaccine; BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Female; Germ Cells; Germ-Line Mutation; Humans; Indazoles; Nitriles; Piperidines

Few data sets of pesticide volatilization from plants at the field scale are available. In this work, we report measurements of fenpropidin and chlorothalonil volatilization on a wheat field using the aerodynamic gradient (AG) method and an inverse dispersion modeling approach (using the FIDES model). Other data necessary to run volatilization models are also reported: measured application dose, crop interception, plant foliage residue, upwind concentrations, and meteorological conditions. The comparison of the AG and inverse modeling methods proved the latter to be reliable and hence suitable for estimating volatilization rates with minimized costs. Different diurnal/nocturnal volatilization patterns were observed: fenpropidin volatilization peaked on the application day and then decreased dramatically, while chlorothalonil volatilization remained fairly stable over a week-long period. Cumulated emissions after 31 h reached 3.5 g ha(-1) and 5 g ha(-1), respectively (0.8% and 0.6% of the theoretical application dose). A larger difference in volatilization rates was expected given differences in vapor pressure, and for fenpropidin, volatilization should have continued given that 80% of the initial amount remained on plant foliage for 6 days. We thus ask if vapor pressure alone can accurately estimate volatilization just after application and then question the state of foliar residue. We identified adsorption, formulation, and extraction techniques as relevant explanations.

Topics: Agriculture; Air; Atmosphere; Friction; Fungicides, Industrial; Meteorological Concepts; Models, Chemical; Nitriles; Pesticide Residues; Piperidines; Plant Leaves; Solutions; Triticum; Vapor Pressure; Volatilization