piperidines and saponite

piperidines has been researched along with saponite* in 1 studies

Other Studies

1 other study(ies) available for piperidines and saponite

Article	Year
Controlled release of donepezil intercalated in smectite clays. International journal of pharmaceutics, 2008, Jul-09, Volume: 359, Issue:1-2 The inorganic-organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules were well stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit E-100) in the release media, the release rate was found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180min). Topics: Acrylates; Adsorption; Aluminum Silicates; Bentonite; Cholinesterase Inhibitors; Delayed-Action Preparations; Donepezil; Drug Carriers; Drug Delivery Systems; Indans; Piperidines; Polymers; Powder Diffraction; Silicates; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Time Factors	2008

Article

Year

Controlled release of donepezil intercalated in smectite clays.

International journal of pharmaceutics, 2008, Jul-09, Volume: 359, Issue:1-2

The inorganic-organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules were well stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit E-100) in the release media, the release rate was found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180min).

Topics: Acrylates; Adsorption; Aluminum Silicates; Bentonite; Cholinesterase Inhibitors; Delayed-Action Preparations; Donepezil; Drug Carriers; Drug Delivery Systems; Indans; Piperidines; Polymers; Powder Diffraction; Silicates; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Time Factors

2008