piperidines and propylurea

piperidines has been researched along with propylurea* in 1 studies

Other Studies

1 other study(ies) available for piperidines and propylurea

Article	Year
Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists. Bioorganic & medicinal chemistry letters, 2004, Apr-05, Volume: 14, Issue:7 The discovery of novel and selective small molecule antagonists of the CC Chemokine Receptor-3 (CCR3) is presented. Simple conversion from a 4- to 3-benzylpiperidine gave improved selectivity for CCR3 over the serotonin 5HT(2A) receptor. Chiral resolution and exploration of mono- and disubstitution of the N-propylurea resulted in several 3-benzylpiperidine N-propylureas with CCR3 binding IC(50)s under 5 nM. Data from in vitro calcium mobilization and chemotaxis assays for these compounds ranged from high picomolar to low nanomolar EC(50)s and correlated well with antagonist binding IC(50)s. Topics: Animals; Cattle; CHO Cells; Cricetinae; Piperidines; Protein Binding; Receptors, CCR3; Receptors, Chemokine; Urea	2004

Article

Year

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.

Bioorganic & medicinal chemistry letters, 2004, Apr-05, Volume: 14, Issue:7

The discovery of novel and selective small molecule antagonists of the CC Chemokine Receptor-3 (CCR3) is presented. Simple conversion from a 4- to 3-benzylpiperidine gave improved selectivity for CCR3 over the serotonin 5HT(2A) receptor. Chiral resolution and exploration of mono- and disubstitution of the N-propylurea resulted in several 3-benzylpiperidine N-propylureas with CCR3 binding IC(50)s under 5 nM. Data from in vitro calcium mobilization and chemotaxis assays for these compounds ranged from high picomolar to low nanomolar EC(50)s and correlated well with antagonist binding IC(50)s.

Topics: Animals; Cattle; CHO Cells; Cricetinae; Piperidines; Protein Binding; Receptors, CCR3; Receptors, Chemokine; Urea

2004