piperidines and prolinamide

piperidines has been researched along with prolinamide* in 1 studies

Other Studies

1 other study(ies) available for piperidines and prolinamide

Article	Year
Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity. Journal of medicinal chemistry, 2006, Feb-09, Volume: 49, Issue:3 A focused library approach identifying novel leads to develop a potent ORL1 antagonist is described. Beginning from a compound identified by random screening, an exploratory library that exhibited a diverse display of pharmacophores was designed. After evaluating ORL1 antagonistic activity, a highly focused library was designed based on 3D-pharmacophore similarity to known actives. A novel D-proline amide class was identified in this library and was found to possess potent ORL1 antagonistic activity. Topics: Animals; Binding, Competitive; CHO Cells; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Proline; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Opioid; Spiro Compounds; Stereoisomerism	2006

Article

Year

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.

Journal of medicinal chemistry, 2006, Feb-09, Volume: 49, Issue:3

A focused library approach identifying novel leads to develop a potent ORL1 antagonist is described. Beginning from a compound identified by random screening, an exploratory library that exhibited a diverse display of pharmacophores was designed. After evaluating ORL1 antagonistic activity, a highly focused library was designed based on 3D-pharmacophore similarity to known actives. A novel D-proline amide class was identified in this library and was found to possess potent ORL1 antagonistic activity.

Topics: Animals; Binding, Competitive; CHO Cells; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Proline; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Opioid; Spiro Compounds; Stereoisomerism

2006