piperidines and phenylcyclohexane

piperidines has been researched along with phenylcyclohexane* in 1 studies

Other Studies

1 other study(ies) available for piperidines and phenylcyclohexane

Article	Year
Exploiting polarity and chirality to probe the Hsp90 C-terminus. Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12 Inhibition of the Hsp90 C-terminus is an attractive therapeutic approach for the treatment of cancer. Novobiocin, the first Hsp90 C-terminal inhibitor identified, contains a synthetically complex noviose sugar that has limited the generation of structure-activity relationships for this region of the molecule. The work described herein utilizes various ring systems as noviose surrogates to explore the size and nature of the surrounding binding pocket. Topics: Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cyclohexanols; HSP90 Heat-Shock Proteins; Humans; MCF-7 Cells; Novobiocin; Piperidines; Protein Domains; Structure-Activity Relationship	2018

Article

Year

Exploiting polarity and chirality to probe the Hsp90 C-terminus.

Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12

Inhibition of the Hsp90 C-terminus is an attractive therapeutic approach for the treatment of cancer. Novobiocin, the first Hsp90 C-terminal inhibitor identified, contains a synthetically complex noviose sugar that has limited the generation of structure-activity relationships for this region of the molecule. The work described herein utilizes various ring systems as noviose surrogates to explore the size and nature of the surrounding binding pocket.

Topics: Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cyclohexanols; HSP90 Heat-Shock Proteins; Humans; MCF-7 Cells; Novobiocin; Piperidines; Protein Domains; Structure-Activity Relationship

2018