piperidines has been researched along with naphthalene* in 3 studies
3 other study(ies) available for piperidines and naphthalene
| Article | Year |
|---|---|
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.
With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H Topics: Administration, Intravenous; Animals; Area Under Curve; Binding Sites; Drug Evaluation, Preclinical; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Half-Life; Histamine; Inhibitory Concentration 50; Molecular Docking Simulation; Naphthalenes; Piperidines; Potassium; Proton Pump Inhibitors; Rats; ROC Curve; Spiro Compounds; Structure-Activity Relationship | 2017 |
The reduction of a nitroxide spin label as a probe of human blood antioxidant properties.
The kinetics of reduction of the radical R*, 5-dimethylaminonaphthalene-1-sulfonyl-4-amino-2,2,6,6-tetramethyl-1-piperidine-oxyl by blood and its components were studied using the EPR technique. The results demonstrate that R* is adsorbed to the outer surface of the membrane and does not penetrate into the erythrocytes. A series of control experiments in PBS demonstrate that ascorbate is the only natural reducing agent that reacts with R*. The observed first order rate of disappearance of the nitroxide radical k, is: k(blood) > k(eryth) > k(plasma) and k(blood) approximately = k(eryth) + k(plasma). The results demonstrate that: a. The erythrocytes catalyze the reduction of R* by ascorbate. b. The rate of reduction of the radical is high though it does not penetrate the cells. c. In human erythrocytes there is an efficient electron transfer route through the cell membrane. d. The study points out that R* is a suitable spin label for measuring the reduction kinetics and antioxidant capacity in blood as expressed by reduction by ascorbate. Topics: Antioxidants; Ascorbic Acid; Blood Chemical Analysis; Cell Membrane; Cyclic N-Oxides; Dansyl Compounds; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Erythrocytes; Ferrocyanides; Hematocrit; Humans; Kinetics; Magnetics; Naphthalenes; Nitric Oxide; Piperidines; Spin Labels; Time Factors | 2003 |
[Studies on synthetic sympatholytics of ergotamine series; new compounds of amine and amide function and tetrahydro-beta-naphthylamine derivatives containing piperidine and morpholine radicals].
Topics: 2-Naphthylamine; Amides; Ergotamine; Morpholines; Naphthalenes; Piperidines; Sympatholytics | 1952 |