piperidines and n-butyllithium

piperidines has been researched along with n-butyllithium* in 2 studies

Other Studies

2 other study(ies) available for piperidines and n-butyllithium

Article	Year
Synthesis and kinetic resolution of N-Boc-2-arylpiperidines. Chemical communications (Cambridge, England), 2014, Sep-07, Volume: 50, Issue:69 The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97 : 3. On lithiation then electrophilic quench, 2,2-disubstituted piperidines were obtained with excellent yields and enantioselectivities. Topics: Kinetics; Organometallic Compounds; Piperidines; Sparteine; Stereoisomerism	2014
Synthesis of 2-arylpiperidines by palladium couplings of aryl bromides with organozinc species derived from deprotonation of N-boc-piperidine. Organic letters, 2008, Sep-04, Volume: 10, Issue:17 The organolithium species derived from proton abstraction of N-Boc-piperidine with s-BuLi and TMEDA can be transmetalated to the organozinc reagent, and this organometallic species can be coupled directly with aryl bromides in a Negishi-type reaction using palladium catalysis with the ligand tri-tert-butylphosphine (t-Bu3P-HBF4). The chemistry was applied to a very short synthesis of the alkaloid anabasine. Topics: Benzene Derivatives; Chlorides; Formic Acid Esters; Organometallic Compounds; Palladium; Piperidines; Zinc Compounds	2008

Article

Year

Synthesis and kinetic resolution of N-Boc-2-arylpiperidines.

Chemical communications (Cambridge, England), 2014, Sep-07, Volume: 50, Issue:69

The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97 : 3. On lithiation then electrophilic quench, 2,2-disubstituted piperidines were obtained with excellent yields and enantioselectivities.

Topics: Kinetics; Organometallic Compounds; Piperidines; Sparteine; Stereoisomerism

2014

Synthesis of 2-arylpiperidines by palladium couplings of aryl bromides with organozinc species derived from deprotonation of N-boc-piperidine.

Organic letters, 2008, Sep-04, Volume: 10, Issue:17

The organolithium species derived from proton abstraction of N-Boc-piperidine with s-BuLi and TMEDA can be transmetalated to the organozinc reagent, and this organometallic species can be coupled directly with aryl bromides in a Negishi-type reaction using palladium catalysis with the ligand tri-tert-butylphosphine (t-Bu3P-HBF4). The chemistry was applied to a very short synthesis of the alkaloid anabasine.

Topics: Benzene Derivatives; Chlorides; Formic Acid Esters; Organometallic Compounds; Palladium; Piperidines; Zinc Compounds

2008