piperidines has been researched along with miltefosine* in 4 studies
4 other study(ies) available for piperidines and miltefosine
| Article | Year |
|---|---|
Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and
New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fashion. The Topics: Animals; Antiprotozoal Agents; Chlorocebus aethiops; Phosphorylcholine; Piperidines; Vero Cells | 2023 |
Successful treatment of cutaneous Acanthamoeba castellanii infection with miltefosine in a patient with chronic lymphocytic leukaemia on ibrutinib.
Topics: Acanthamoeba castellanii; Adenine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphorylcholine; Piperidines | 2022 |
Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies.
Tetradecylphosphocholine (TPC), hexadecylphosphocholine (HPC), hexadecylphospho(N-N-N-trimethyl)hexanolamine (HPC6), octadecylphosphocholine (OPC), and octadecyl-[2-(N-methylpiperidinio)ethyl]-phosphate (OMPEP) were investigated for antitrypanosomal activity in vitro and in vivo. OMPEP showed the best trypanocidal efficacy in vitro; it was superior to the model compound HPC and comparable to the reference compound alpha-DFMO. HPC showed moderate activity in vivo in terms of increased life expectancy (up to 35% in the acute NMRI-mouse model or 49% if combined with phenylbutazone) and increased packed cell volume, if administered daily. However, HPC and the other alkylphosphocholines failed to prolong survival time of treated mice if given intermittently. Phenylbutazone had no own trypanocidal effect but increased the efficacy of alkylphosphocholines in vitro and in vivo: the combination of HPC and phenylbutazone acted apparently synergistic. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Synergism; Drug Therapy, Combination; Female; Mice; Microbial Sensitivity Tests; Molecular Structure; Phenylbutazone; Phosphorylcholine; Piperidines; Platelet Activating Factor; Specific Pathogen-Free Organisms; Trypanosoma brucei brucei; Trypanosomiasis, African | 1997 |
Antineoplastic activity and tolerability of a novel heterocyclic alkylphospholipid, D-20133.
Octadecyl-[2-(N-methylpiperidinio)ethyl]-phosphate (OMPEP, D-20133), a heterocyclic analogue of hexadecylphosphocholine (MIL), has been synthesized in an attempt to increase the therapeutic range of the parent compound. The antineoplastic activity of the novel alkylphospholipid was compared with that of MIL in dimethylbenz(a)anthracene-induced mammary carcinoma of the rat. Using tumors of different sizes and repeated daily doses as well as high single doses, we achieved marked remissions with either compound. However, the therapeutic range of OMPEP was broader than that of the parent drug. Furthermore, the emetic potential of OMPEP tested on ferrets was distinctly less pronounced than that of MIL. In vitro the new alkylphospholipid proved to be more active than MIL in all cell lines tested, and its differentiation-inducing capacity turned out to be superior to that of MIL. No hematological toxicity was observed at various OMPEP doses during a 3-week treatment period. Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Cell Differentiation; Female; Ferrets; Mammary Neoplasms, Experimental; Phosphorylcholine; Piperidines; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Vomiting | 1993 |