piperidines and landiolol

The aim of this study was to examine the effects of landiolol on bispectral index scores (BIS) during surgery.. Twenty patients undergoing total hysterectomy were allocated into two groups; 1) 10 patients not receiving landiolol (C group), 2) 10 patients receiving landiolol 125 microg x kg(-1) x min(-1) for one minute followed by 40 microg x kg(-1) x min(-1) (L group). They were anesthetized with sevoflurane (end-tidal concentration of 1.0%) combined with a continuous infusion of remifentanil at 0.25 microg x kg(-1) x min(-1). Mean arterial pressure (MAP), heart rate (HR) and BIS were recorded 4 times (immediately before the skin incision, 5 minutes after the skin incision, at the moment of uterine extraction and during retroperitoneal closure).. No significant differences were found in MAP and BIS between the groups at any time points, while HR in the L groups was lower than that in the C group throughout the study period.. This study suggests that landiolol has no effects on BIS in patients undergoing lower abdominal surgery during sevoflurane-remifentanil anesthesia.

Topics: Adrenergic beta-Antagonists; Adult; Anesthesia; Consciousness Monitors; Female; Humans; Hysterectomy; Methyl Ethers; Middle Aged; Morpholines; Piperidines; Remifentanil; Sevoflurane; Urea

beta1-Adrenoceptor antagonists suppress the haemodynamic and arousal responses to tracheal intubation. The Entropy Module shows two spectral entropy-based indices, response entropy (RE) and state entropy (SE). The difference between RE and SE (RE-SE) may reflect nociception during general anaesthesia. In the present study, we investigated the effect of landiolol on entropy indices in response to tracheal intubation.. A total of 60 patients were randomly assigned to receive saline (Group S), remifentanil (Group R), or landiolol (Group L). Anaesthesia was induced by propofol target-controlled infusion. Two minutes after the induction of anaesthesia, infusion with vecuronium bromide and remifentanil, landiolol, or saline was initiated. Tracheal intubation was performed 7 min after anaesthesia induction. Arterial pressure, heart rate (HR), bispectral index (BIS), and entropy indices were recorded.. In Group S, RE increased significantly after tracheal intubation, but there was no significant increase in BIS or SE. These increases in RE were abolished in Groups R and L. RE-SE increased significantly after tracheal intubation in Group S, whereas no increase in RE-SE was observed in Groups R and L. Increases in mean arterial pressure and HR after tracheal intubation were suppressed in Groups R and L compared with Group S.. RE increased in response to tracheal intubation, whereas BIS and SE did not. Landiolol and remifentanil suppressed the increase in RE after tracheal intubation with significant inhibition of RE-SE difference.

Topics: Adrenergic beta-Antagonists; Adult; Aged; Anesthetics, Intravenous; Double-Blind Method; Electroencephalography; Entropy; Female; Humans; Intubation, Intratracheal; Male; Middle Aged; Monitoring, Intraoperative; Morpholines; Piperidines; Propofol; Remifentanil; Signal Processing, Computer-Assisted; Urea

We sought to examine whether the antiarrhythmic effect of E4031 (E), or I(Kr) channel blocker, is affected by beta-adrenergic stimulation using isoproterenol (Iso) or by beta-adrenergic blockade (betaB) using, ONO1101, in a canine myocardial infarction model. Electrophysiologic studies were performed in 10 dogs with 7-day-old myocardial infarctions. Local QT intervals were measured at 47 sites on the infarcted myocardium using a mapping electrode. QT dispersion (QTd), as defined by the coefficient of variation of QT intervals, was obtained. Inducibility of ventricular arrhythmias was examined by programmed stimulation. These procedures were repeated during administration of E, E + Iso, and E + betaB. The effect of prolonging local QT intervals by E was counteracted by Iso, and was accentuated by betaB. The amount of prolongation was dependent on the baseline QT intervals, and QTd showed a tendency to decrease with E, to increase with E + Iso, and significantly decreased with E + betaB. Ventricular tachyarrhythmias were induced in a half of dogs with E + Iso, but were not induced with E + betaB. In the presence of adrenergic activation, I(Kr) blockers may exhibit a decreased antiarrhythmic effect. Beneficial synergism can be expected when an I(Kr) blocker is combined with a beta-blocker in the subacute phase of myocardial infarction.

Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Drug Therapy, Combination; Electrocardiography; Female; Heart; Heart Ventricles; Male; Morpholines; Myocardial Infarction; Piperidines; Potassium Channel Blockers; Pyridines; Urea