piperidines and hypobromous-acid

piperidines has been researched along with hypobromous-acid* in 1 studies

Other Studies

1 other study(ies) available for piperidines and hypobromous-acid

Article	Year
DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis. Cancer letters, 2002, Apr-08, Volume: 178, Issue:1 Hypohalites (OCl-, OBr-) are formed at inflammation sites as antimicrobial agents. OCl- is also used for the disinfection of water supplies and the association of drinking chlorinated water with cancer risk is pointed out. In this study, OCl- itself induced 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation, while OBr- damaged DNA only when glutathione (GSH) was added. OCl- caused oxidative DNA damage more efficiently than OBr-/GSH. In experiment with 32P-labeled DNA fragments, OCl- strongly caused piperidine-labile sites at guanine residues than piperidine-inert 8-oxodG, whereas OBr-/GSH caused no piperidine-labile sites. Endogenous OCl- may play a role in genotoxicity close to the site of inflammation. Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bromates; Carcinogens; Cattle; Cell Line; Deoxyguanosine; Dimethyl Sulfoxide; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Glutathione; Humans; Inflammation; Neoplasms; Oxidation-Reduction; Phosphorus Isotopes; Piperidines; Sodium Hypochlorite	2002

Article

Year

DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis.

Cancer letters, 2002, Apr-08, Volume: 178, Issue:1

Hypohalites (OCl-, OBr-) are formed at inflammation sites as antimicrobial agents. OCl- is also used for the disinfection of water supplies and the association of drinking chlorinated water with cancer risk is pointed out. In this study, OCl- itself induced 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation, while OBr- damaged DNA only when glutathione (GSH) was added. OCl- caused oxidative DNA damage more efficiently than OBr-/GSH. In experiment with 32P-labeled DNA fragments, OCl- strongly caused piperidine-labile sites at guanine residues than piperidine-inert 8-oxodG, whereas OBr-/GSH caused no piperidine-labile sites. Endogenous OCl- may play a role in genotoxicity close to the site of inflammation.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bromates; Carcinogens; Cattle; Cell Line; Deoxyguanosine; Dimethyl Sulfoxide; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Glutathione; Humans; Inflammation; Neoplasms; Oxidation-Reduction; Phosphorus Isotopes; Piperidines; Sodium Hypochlorite

2002