piperidines and halopemide

piperidines has been researched along with halopemide* in 5 studies

Other Studies

5 other study(ies) available for piperidines and halopemide

ArticleYear
Effects of halopemide on GABA receptor binding, uptake and release.
    Brain research, 1981, Apr-06, Volume: 210, Issue:1-2

    Topics: Animals; Benzimidazoles; Binding, Competitive; Brain; Domperidone; gamma-Aminobutyric Acid; Kinetics; Male; Piperidines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sodium; Tranquilizing Agents

1981
Effects of halopemide on potassium-induced release of radiolabeled neurotransmitters from rat cerebrocortical slices in vitro.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 247, Issue:1

    The effects of halopemide on the release of 3H-serotonin, 3H-noradrenaline, 3H-acetylcholine and 3H-GABA from rat frontal cortical slices in vitro were studied and compared to those of its neuroleptic congener R29800, spiperone and haloperidol. Spontaneous 3H-serotonin and to a lesser extend 3H-noradrenaline outflow were augmented by the agents, while the effects on basal 3H-acetylcholine and 3H-GABA release were small or absent. Mechanism explaining these effects are discussed. Depolarization-induced release of serotonin was affected more markedly than the extra overflow of other radiolabeled transmitters, but the statistical significant of the response was limited.

    Topics: Acetylcholine; Animals; Antipsychotic Agents; Benzimidazoles; Cerebral Cortex; Domperidone; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neurotransmitter Agents; Norepinephrine; Piperidines; Potassium; Rats; Serotonin

1980
Regional distribution of halopemide, a new psychotropic agent, in the rat brain at different time intervals and after chronic administration.
    Life sciences, 1979, Feb-12, Volume: 24, Issue:7

    Topics: Animals; Benzimidazoles; Brain; Domperidone; Male; Piperidines; Pituitary Gland; Rats; Time Factors; Tranquilizing Agents

1979
Dynamic cation-exchange systems for the separation of drugs derived from butyrophenone and diphenylpiperidine by high-performance liquid chromatography and applied in the determination of halopemide in plasma.
    Journal of chromatography, 1979, Oct-11, Volume: 164, Issue:2

    Dynamic (solvent generated) cation-exchange systems for the separation of drugs and main metabolites derived from butyrophenone and diphenylpiperidine (haloperidol, pimozide, halopemide) were investigated. The effect of organic modifier, detergent, counter-ion concentration and of the pH on the retention has been determined. The results show that variation of these parameters permits adjustment of the retention of these drugs over a wide range. The dynamic cation-exchange system developed was applied to the determination of halopemide and its main metabolite in plasma. The precision and detection limit of the method and the extraction efficiency were established. The time course of halopemide and plasma levels of patients chronically receiving halopemide are reported.

    Topics: Benzimidazoles; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Domperidone; Haloperidol; Humans; Pimozide; Piperidines; Solvents; Tranquilizing Agents

1979
Regional localization of halopemide, a new psychotropic agent, in the rat brain.
    European journal of pharmacology, 1978, Aug-15, Volume: 50, Issue:4

    Halopemide is a new psychotropic agent, structurally related to the neuroleptics of the butyrophenone type, but with a different phamacological and clinical profile. The concentration of halopemide in the rat brain is about 10 times less than that of R29800, its chemical congener and of spiperone, both typical neuroleptics. In the pituitary gland, however, the levels are the same. The distribution profile of halopemide in rat brain deviates from that of neuroleptics. The highest level of halopemide is found in septal and thalamic areas whereas the neuroleptics are concentrated in the caudate nucleus, the nucleus accumbens and the tuberculum olfactorium. Subcellular distribution experiments show that in the caudate nucleus halopemide is far less particle-bound that are the neuroleptic agents.

    Topics: Animals; Antipsychotic Agents; Benzimidazoles; Brain; Butyrophenones; Caudate Nucleus; Domperidone; Male; Piperidines; Psychotropic Drugs; Rats; Spiperone; Subcellular Fractions; Time Factors

1978