piperidines and fanasil--pyrimethamine-drug-combination

piperidines has been researched along with fanasil--pyrimethamine-drug-combination* in 2 studies

Reviews

1 review(s) available for piperidines and fanasil--pyrimethamine-drug-combination

Article	Year
[Urgent need for new antimalarias (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1981, Jun-02, Volume: 70, Issue:23 Topics: Antimalarials; Biological Availability; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Immunotherapy; Mefloquine; Piperidines; Pyrimethamine; Quinolines; Sulfadoxine; World Health Organization	1981

Other Studies

1 other study(ies) available for piperidines and fanasil--pyrimethamine-drug-combination

Article	Year
Highly sensitive and specific determination of mefloquine in biological fluids using gas chromatography mass spectrometry with selected ion monitoring. Biomedical mass spectrometry, 1981, Volume: 8, Issue:12 A highly sensitive and specific assay for the determination of racemic erythro-alpha-(2-piperidyl)-2,8-bis(trifluoro-methyl)-4-quinoline-methanol in whole blood, plasma and urine has been developed. The method involves the extraction of the drug together with an internal standard, formation of the corresponding O-trimethylsilyl-N-trifluoroacetyl derivatives, gas chromatographic separation and mass spectrometric measurement of the peaks by selected ion monitoring. The method has a sensitivity of 1 ng ml-1 for plasma and 3 ng ml-1 for whole blood or urine. It has been applied to the analysis of mefloquine in plasma following an oral dose of 250 mg of the drug to healthy subjects. No interference was observed from the simultaneous administration of Fansidar. Topics: Drug Combinations; Gas Chromatography-Mass Spectrometry; Humans; Mefloquine; Piperidines; Pyrimethamine; Quinolines; Sulfadoxine	1981

Article

Year

Highly sensitive and specific determination of mefloquine in biological fluids using gas chromatography mass spectrometry with selected ion monitoring.

Biomedical mass spectrometry, 1981, Volume: 8, Issue:12

A highly sensitive and specific assay for the determination of racemic erythro-alpha-(2-piperidyl)-2,8-bis(trifluoro-methyl)-4-quinoline-methanol in whole blood, plasma and urine has been developed. The method involves the extraction of the drug together with an internal standard, formation of the corresponding O-trimethylsilyl-N-trifluoroacetyl derivatives, gas chromatographic separation and mass spectrometric measurement of the peaks by selected ion monitoring. The method has a sensitivity of 1 ng ml-1 for plasma and 3 ng ml-1 for whole blood or urine. It has been applied to the analysis of mefloquine in plasma following an oral dose of 250 mg of the drug to healthy subjects. No interference was observed from the simultaneous administration of Fansidar.

Topics: Drug Combinations; Gas Chromatography-Mass Spectrometry; Humans; Mefloquine; Piperidines; Pyrimethamine; Quinolines; Sulfadoxine

1981