piperidines and diphenyl-sulfoxide

piperidines has been researched along with diphenyl-sulfoxide* in 1 studies

Other Studies

1 other study(ies) available for piperidines and diphenyl-sulfoxide

Article	Year
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor. Bioorganic & medicinal chemistry letters, 2000, Oct-16, Volume: 10, Issue:20 Structure activity studies on [4-(phenylsulfonyl)phenyl]methylpiperazine led to the discovery of 4-cyclohexyl-alpha-[4-[[4-methoxyphenyl(S)-sufinyl]phenyl]-1-pi perazineacetonitrile, 1, an M2 selective muscarinic antagonist. Affinity at the cloned human M2 receptor was 2.7 nM; the M1/M2 selectivity is 40-fold. Topics: Acetylcholine; Administration, Oral; Alkaloids; Animals; Benzene Derivatives; Corpus Striatum; Dibenzazepines; Drug Design; Furans; Humans; Muscarinic Antagonists; Naphthalenes; Piperidines; Pyridines; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Structure-Activity Relationship	2000

Article

Year

Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.

Bioorganic & medicinal chemistry letters, 2000, Oct-16, Volume: 10, Issue:20

Structure activity studies on [4-(phenylsulfonyl)phenyl]methylpiperazine led to the discovery of 4-cyclohexyl-alpha-[4-[[4-methoxyphenyl(S)-sufinyl]phenyl]-1-pi perazineacetonitrile, 1, an M2 selective muscarinic antagonist. Affinity at the cloned human M2 receptor was 2.7 nM; the M1/M2 selectivity is 40-fold.

Topics: Acetylcholine; Administration, Oral; Alkaloids; Animals; Benzene Derivatives; Corpus Striatum; Dibenzazepines; Drug Design; Furans; Humans; Muscarinic Antagonists; Naphthalenes; Piperidines; Pyridines; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Structure-Activity Relationship

2000