piperidines and diethyl-aminomalonate

piperidines has been researched along with diethyl-aminomalonate* in 1 studies

Other Studies

1 other study(ies) available for piperidines and diethyl-aminomalonate

ArticleYear
A heterocycle-forming double michael reaction. [5 + 1] annulation route to highly substituted and functionalized piperidines.
    Organic letters, 2001, Sep-06, Volume: 3, Issue:18

    [reaction: see text]. Nitrogen-containing tethered diacids, easily prepared by reductive alkylation of diethyl aminomalonate or ethyl cyanoglycinate, undergo double Michael reactions with 3-butyn-2-one to give highly functionalized and substituted piperidines (pipecolic acid derivatives) with surprisingly high stereoselectivity. The heterocyclic double Michael adducts can be induced to undergo further cyclizations to give a variety of azabicyclic and diazabicyclic compounds.

    Topics: Alkylation; Malonates; Molecular Conformation; Piperidines

2001