piperidines has been researched along with diethyl-aminomalonate* in 1 studies
1 other study(ies) available for piperidines and diethyl-aminomalonate
Article | Year |
---|---|
A heterocycle-forming double michael reaction. [5 + 1] annulation route to highly substituted and functionalized piperidines.
[reaction: see text]. Nitrogen-containing tethered diacids, easily prepared by reductive alkylation of diethyl aminomalonate or ethyl cyanoglycinate, undergo double Michael reactions with 3-butyn-2-one to give highly functionalized and substituted piperidines (pipecolic acid derivatives) with surprisingly high stereoselectivity. The heterocyclic double Michael adducts can be induced to undergo further cyclizations to give a variety of azabicyclic and diazabicyclic compounds. Topics: Alkylation; Malonates; Molecular Conformation; Piperidines | 2001 |