piperidines has been researched along with denopamine* in 2 studies
1 review(s) available for piperidines and denopamine
| Article | Year |
|---|---|
[New oral drugs for the treatment of congestive heart failure].
The crucial issues in the management of congestive heart failure (CHF) are improvement of depressed myocardial contractility and reduction of excessive load. For this purpose, positive inotropic agents and vasodilators have been developed as new oral drugs. The former include Denopamine which possesses beta 1 stimulating effect, Xamoterol which is a unique agent acting as a beta 1-partial agonist, and Ibopamine, Docarpamine and Phosphodiesterase Inhibitors which possess both inotropic and vasodilating effects and are called "Inodilators". The latter include Angiotensin Converting Enzyme Inhibitors. In addition, new vasodilators, such as, Vasopressin Antagonist have also been developed. However, careful long-term clinical trials are required with regard to the efficacy and adverse effects before these agents are widely used with safety in the management of CHF. Topics: Administration, Oral; Cardiotonic Agents; Deoxyepinephrine; Ethanolamines; Heart Failure; Humans; Phosphodiesterase Inhibitors; Piperidines; Propanolamines; Pyrazines; Quinolines; Quinolones; Vasodilator Agents; Xamoterol | 1992 |
1 other study(ies) available for piperidines and denopamine
| Article | Year |
|---|---|
Relationship between positive inotropic action and blood levels of denopamine in cats.
The relationship between the positive inotropic action and blood levels of (-)-(R)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol (denopamine, TA-064) was studied after intraduodenal administration of 3H-denopamine (100 micrograms/kg) in cats. The increase in cardiac contractile force attained the peak (about 100% increase) 15 min after the administration and the effect persisted for over 90 min. The blood levels of denopamine also reached the peak at 15 min with a concentration of 20 ng/ml and decreased gradually thereafter. Thus, it was indicated that the time courses of the increase in cardiac contractile force were closely related to those of blood levels of the drug. Furthermore, denopamine was distributed to the liver, kidney, parotid gland and heart, followed by being excreted into the urine and bile mostly as metabolites. Topics: Animals; Bile; Biotransformation; Cardiotonic Agents; Cats; Ethanolamines; Female; Myocardial Contraction; Piperidines; Stimulation, Chemical; Tissue Distribution | 1985 |