piperidines has been researched along with coumaperine* in 4 studies
4 other study(ies) available for piperidines and coumaperine
| Article | Year |
|---|---|
Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from
Bacterial communication, termed Quorum Sensing (QS), is a promising target for virulence attenuation and the treatment of bacterial infections. Infections cause inflammation, a process regulated by a number of cellular factors, including the transcription Nuclear Factor kappa B (NF-κB); this factor is found to be upregulated in many inflammatory diseases, including those induced by bacterial infection. In this study, we tested 32 synthetic derivatives of coumaperine (CP), a known natural compound found in pepper ( Topics: Anti-Bacterial Agents; NF-kappa B; Piper nigrum; Piperidines; Quorum Sensing | 2021 |
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.
Topics: Antioxidants; Arachidonate 5-Lipoxygenase; Catalytic Domain; Drug Design; Enzyme Assays; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Molecular Docking Simulation; Molecular Structure; Peroxidases; Piperidines; Structure-Activity Relationship | 2019 |
Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Humans; Neoplasms; NF-kappa B; Piper nigrum; Piperidines; Signal Transduction | 2017 |
Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat.
This study was designed to investigate the chemopreventive action of three natural products, coumaperine, aurapten and an extract from rosemary, against the initiation stage of rat hepato-carcinogenesis. Coumaperine has been isolated from white pepper as a naturally occurring antioxidative agent, but its potential modifying effects on carcinogenesis remain unclear. In experiment 1, a modification of the model developed by Tsuda et al. was applied, with assessment of numbers and areas of induced glutathione S-transferase placental form (GST-P)-positive hepatocellular foci in male F344 rats. Coumaperine, aurapten and the extract from rosemary were administered i.g. at 100 mg / kg / day once daily for 5 days with initiation by diethylnitrosamine (DEN) on day 4 (20 mg / kg, i.p.). Numbers and areas of GST-P-positive foci in each group given test chemicals tended to be decreased as compared to the vehicle control group values, significance being achieved for number with coumaperine. Experiment 2 was planned to investigate the mechanism of the inhibitory effects of coumaperine. Livers at 8 h after initiation by DEN were examined with coumaperine administered at 100 mg / kg / day once daily for 3 days. Proliferating cell nuclear antigen (PCNA)-positive cells tended to be decreased as compared to the vehicle control, but no effects on apoptosis or cytochrome P-450 (CYP) 2E1 expression were apparent. Our results suggest that coumaperine provides protection against initiation of hepatocarcinogenesis, and that this is related to inhibition of cell proliferation. Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Division; Coumarins; Diethylnitrosamine; Gene Expression; Glutathione Transferase; Immunohistochemistry; Lamiaceae; Liver; Liver Neoplasms, Experimental; Male; Nucleolus Organizer Region; Piperidines; Plant Extracts; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Silver Staining; Spices | 2000 |