piperidines and corydaline

Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future.

Topics: Antiviral Agents; Berberine Alkaloids; Cyclooxygenase 2 Inhibitors; Enterovirus A, Human; Humans; JNK Mitogen-Activated Protein Kinases; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyridazines; Signal Transduction; Virus Replication