piperidines and carbon-tetrabromide

piperidines has been researched along with carbon-tetrabromide* in 1 studies

Other Studies

1 other study(ies) available for piperidines and carbon-tetrabromide

Article	Year
Design, synthesis, and biological evaluation of andrographolide derivatives as potent hepatoprotective agents. Chemical biology & drug design, 2014, Volume: 83, Issue:3 Poor water solubility limits the clinical use of andrographolide and its derivatives. In an attempt to develop potent hepatoprotective drugs, a strategy was proposed to improve the aqueous solubility of andrographolide. Ten andrographolide derivatives were designed, synthesized, evaluated for aqueous solubility and in vivo hepatoprotective activity against CCl4 -induced liver injury in mice. As expected, the aqueous solubility of synthetic derivatives was effectively improved. All compounds demonstrated the effect of different degrees in improving the liver enzyme (ALT and AST) activity, especially the most promising compound 9d significantly improved liver enzyme activity, with high potency to be a new lead. Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diterpenes; Drug Design; Hydrocarbons, Brominated; Liver; Mice; Piperidines; Protective Agents; Solubility; Water	2014

Article

Year

Design, synthesis, and biological evaluation of andrographolide derivatives as potent hepatoprotective agents.

Chemical biology & drug design, 2014, Volume: 83, Issue:3

Poor water solubility limits the clinical use of andrographolide and its derivatives. In an attempt to develop potent hepatoprotective drugs, a strategy was proposed to improve the aqueous solubility of andrographolide. Ten andrographolide derivatives were designed, synthesized, evaluated for aqueous solubility and in vivo hepatoprotective activity against CCl4 -induced liver injury in mice. As expected, the aqueous solubility of synthetic derivatives was effectively improved. All compounds demonstrated the effect of different degrees in improving the liver enzyme (ALT and AST) activity, especially the most promising compound 9d significantly improved liver enzyme activity, with high potency to be a new lead.

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diterpenes; Drug Design; Hydrocarbons, Brominated; Liver; Mice; Piperidines; Protective Agents; Solubility; Water

2014