piperidines and calvatic-acid

piperidines has been researched along with calvatic-acid* in 1 studies

Other Studies

1 other study(ies) available for piperidines and calvatic-acid

Article	Year
Anti-Helicobacter pylori agents endowed with H2-antagonist properties. Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3 New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole. Topics: Animals; Anti-Bacterial Agents; Benzoates; Binding, Competitive; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Heart Atria; Helicobacter pylori; Histamine; Histamine H2 Antagonists; Metronidazole; Microbial Sensitivity Tests; Nitriles; Piperidines; Receptors, Histamine H2; Structure-Activity Relationship; Triazoles	2001

Article

Year

Anti-Helicobacter pylori agents endowed with H2-antagonist properties.

Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3

New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.

Topics: Animals; Anti-Bacterial Agents; Benzoates; Binding, Competitive; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Heart Atria; Helicobacter pylori; Histamine; Histamine H2 Antagonists; Metronidazole; Microbial Sensitivity Tests; Nitriles; Piperidines; Receptors, Histamine H2; Structure-Activity Relationship; Triazoles

2001