piperidines and bromopride

A retrospective study is reported carried out on a group of 166 patients affected by dyspeptic syndrome who presented at least 3 of the 9 symptoms which characterise this pathology. One hundred and twenty-eight patients underwent prokinetic drug therapy and 38 received placebo. Clinical parameters were evaluated following one month of therapy all patients in order to compare them to basal values. The results obtained confirm a satisfactory efficacy of the prokinetic treatment in improving dyspeptic symptoms. Although administered to a smaller number of patients, placebo was also found to play an important role in the multifactorial etiopathogenesis of the dyspeptic syndrome on a functional basis.

Topics: Adult; Antiemetics; Benzamides; Cisapride; Domperidone; Dyspepsia; Female; Humans; Male; Metoclopramide; Middle Aged; Piperidines; Retrospective Studies; Serotonin Antagonists

This double-blind and cross-over study was designed to compare the effect of domperidon, metoclopramide and bromopride on esophageal motility. A stimulating effect on lower esophageal sphincter pressure (LESP) was shown after i.v. bolus of all three substances, not after saline (control period). LESP was rised significantly up to 50 min above basal levels. Motility pattern of the esophagus was also stimulated up to 50 min.

Topics: Adult; Benzimidazoles; Domperidone; Esophagogastric Junction; Female; Gastroesophageal Reflux; Humans; Male; Metoclopramide; Piperidines