piperidines and bevirimat

The late stages of the HIV-1 replication cycle are important to the overall replication cycle. During the late stages, HIV-1 replication undergoes the processes of assembly, release, and maturation, resulting in the production of a mature virus particle capable of infecting a new target cell. The structural protein Gag and its related gene (protein) play a central role in these pathways. The different regions of Gag worked in concert to drive production of a mature infectious particle through protein-protein, protein-RNA and protein-lipid interactions. The designed drug aimed directly at these stages can efficiently block the maturation and infectivity of HIV-1. In this article, the role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and related inhibitors is reviewed.

Topics: Amphotericin B; Anti-HIV Agents; Benzeneacetamides; Furans; gag Gene Products, Human Immunodeficiency Virus; Genes, gag; HIV-1; Humans; Phenylurea Compounds; Piperidines; Succinates; Sulfur Compounds; Triterpenes; Virus Assembly; Virus Release; Virus Replication