piperidines and benzonitrile

piperidines has been researched along with benzonitrile* in 1 studies

Other Studies

1 other study(ies) available for piperidines and benzonitrile

Article	Year
Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-( Molecules (Basel, Switzerland), 2018, 06-26, Volume: 23, Issue:7 Because lysine-specific demethylase 1 (LSD1) regulates the maintenance of cancer stem cell properties, small-molecule inhibitors of LSD1 are expected to be useful for the treatment of several cancers. Reversible inhibitors of LSD1 with submicromolar inhibitory potency have recently been reported, but their exact binding modes are poorly understood. In this study, we synthesized a recently reported reversible inhibitor, 4-[5-(piperidin-4-ylmethoxy)-2-( Topics: Co-Repressor Proteins; Crystallography, X-Ray; Histone Demethylases; Histones; Humans; Models, Molecular; Nerve Tissue Proteins; Nitriles; Peptides; Piperidines; Protein Binding; Pyridines; Substrate Specificity	2018

Article

Year

Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(

Molecules (Basel, Switzerland), 2018, 06-26, Volume: 23, Issue:7

Because lysine-specific demethylase 1 (LSD1) regulates the maintenance of cancer stem cell properties, small-molecule inhibitors of LSD1 are expected to be useful for the treatment of several cancers. Reversible inhibitors of LSD1 with submicromolar inhibitory potency have recently been reported, but their exact binding modes are poorly understood. In this study, we synthesized a recently reported reversible inhibitor, 4-[5-(piperidin-4-ylmethoxy)-2-(

Topics: Co-Repressor Proteins; Crystallography, X-Ray; Histone Demethylases; Histones; Humans; Models, Molecular; Nerve Tissue Proteins; Nitriles; Peptides; Piperidines; Protein Binding; Pyridines; Substrate Specificity

2018