piperidines and benzimidazol-2-one

piperidines has been researched along with benzimidazol-2-one* in 1 studies

Other Studies

1 other study(ies) available for piperidines and benzimidazol-2-one

Article	Year
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach. Bioorganic & medicinal chemistry letters, 2009, Nov-15, Volume: 19, Issue:22 A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement of the benzimidazol-2-one moiety was explored. Compound 51 was found to be a high affinity, potent NOP receptor agonist with reduced affinity for the hERG channel. Topics: Animals; Benzimidazoles; Cricetinae; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Receptors, Opioid; Structure-Activity Relationship	2009

Article

Year

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.

Bioorganic & medicinal chemistry letters, 2009, Nov-15, Volume: 19, Issue:22

A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement of the benzimidazol-2-one moiety was explored. Compound 51 was found to be a high affinity, potent NOP receptor agonist with reduced affinity for the hERG channel.

Topics: Animals; Benzimidazoles; Cricetinae; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Receptors, Opioid; Structure-Activity Relationship

2009