piperidines has been researched along with aziridine-2-carboxylic-acid* in 1 studies
1 other study(ies) available for piperidines and aziridine-2-carboxylic-acid
| Article | Year |
|---|---|
Aziridine carboxylate from D-glucose: synthesis of polyhydroxylated piperidine, pyrrolidine alkaloids and study of their glycosidase inhibition.
The D-glucose derived aziridine carboxylate 5 was obtained from (E)-ethyl-6-bromo-1,2-O-isopropylidene-3-O-benzyl-5-deoxy-alpha-D-xylo-5-eno-heptofuranuronate 4 through conjugate addition of benzylamine and in situ intramolecular nucleophilic expulsion of bromine. The regioselective aziridine ring-opening, using water as a nucleophile, resulted in the alpha-hydroxy-beta-aminoester 6, which was exploited in the synthesis of six and five membered azasugars 1b/1c and 2b/2c, respectively. The glycosidase inhibitory activity of the title compounds was evaluated. Topics: Alkaloids; Aziridines; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Glucose; Glycoside Hydrolases; Models, Molecular; Molecular Structure; Piperidines; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship | 2005 |