piperidines and anthranilamide

piperidines has been researched along with anthranilamide* in 2 studies

Other Studies

2 other study(ies) available for piperidines and anthranilamide

Article	Year
Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties. Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9 Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model. Topics: Administration, Oral; Animals; Antithrombin III; Arteriovenous Shunt, Surgical; Binding Sites; Biological Availability; Models, Animal; ortho-Aminobenzoates; Piperidines; Pyridones; Rabbits; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thrombosis	2008
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity. Bioorganic & medicinal chemistry, 2004, Jan-15, Volume: 12, Issue:2 Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity. Topics: Animals; Avoidance Learning; Biochemistry; Biological Availability; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Muscarinic Antagonists; ortho-Aminobenzoates; Piperidines; Rats; Receptor, Muscarinic M2; Structure-Activity Relationship	2004

Article

Year

Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.

Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9

Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.

Topics: Administration, Oral; Animals; Antithrombin III; Arteriovenous Shunt, Surgical; Binding Sites; Biological Availability; Models, Animal; ortho-Aminobenzoates; Piperidines; Pyridones; Rabbits; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thrombosis

2008

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.

Bioorganic & medicinal chemistry, 2004, Jan-15, Volume: 12, Issue:2

Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity.

Topics: Animals; Avoidance Learning; Biochemistry; Biological Availability; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Muscarinic Antagonists; ortho-Aminobenzoates; Piperidines; Rats; Receptor, Muscarinic M2; Structure-Activity Relationship

2004