piperidines and alosetron

piperidines has been researched along with alosetron* in 1 studies

Other Studies

1 other study(ies) available for piperidines and alosetron

Article	Year
Alosetron and the rapid component of delayed rectifying potassium current in cardiac cells. Life sciences, 2001, Feb-23, Volume: 68, Issue:14 Some drugs acting on 5-hydroxytryptamine receptors inhibit the rapid component of delayed rectifying potassium currents (I(Kr)) in cardiac muscle cells. This is associated with lengthening of the QT interval in the cardiac cycle and can lead to fatal arrhythmias. We investigated whether alosetron, a novel 5HT3 antagonist proposed for treatment of irritable bowel syndrome (IBS), blocks I(Kr) in guinea pig cardiac myocytes. I(Kr) was isolated under whole-cell voltage clamp, and was identified by its sensitivity to the selective I(Kr) antagonist E4031. Cisapride (10(-6) M) inhibited the E4031-sensitive current while alosetron (10(-10)-10(-6) M) had no effect on I(Kr). We also found that alosetron did not inhibit I(Ks). Therefore, use of alosetron for treatment of IBS should not be confounded by long QT syndrome. Topics: Animals; Carbolines; Cisapride; Delayed Rectifier Potassium Channels; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists	2001

Article

Year

Alosetron and the rapid component of delayed rectifying potassium current in cardiac cells.

Life sciences, 2001, Feb-23, Volume: 68, Issue:14

Some drugs acting on 5-hydroxytryptamine receptors inhibit the rapid component of delayed rectifying potassium currents (I(Kr)) in cardiac muscle cells. This is associated with lengthening of the QT interval in the cardiac cycle and can lead to fatal arrhythmias. We investigated whether alosetron, a novel 5HT3 antagonist proposed for treatment of irritable bowel syndrome (IBS), blocks I(Kr) in guinea pig cardiac myocytes. I(Kr) was isolated under whole-cell voltage clamp, and was identified by its sensitivity to the selective I(Kr) antagonist E4031. Cisapride (10(-6) M) inhibited the E4031-sensitive current while alosetron (10(-10)-10(-6) M) had no effect on I(Kr). We also found that alosetron did not inhibit I(Ks). Therefore, use of alosetron for treatment of IBS should not be confounded by long QT syndrome.

Topics: Animals; Carbolines; Cisapride; Delayed Rectifier Potassium Channels; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists

2001