piperidines and 9-aminoacridine-4-carboxamide

piperidines has been researched along with 9-aminoacridine-4-carboxamide* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 9-aminoacridine-4-carboxamide

Article	Year
DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest. Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8 We describe the synthesis of a series of DNA-threading bis(9-aminoacridine-4-carboxamides) comprising ethylpiperidino and N-methylpiperidin-4-yl sidechains, joined via neutral flexible alkyl chains, charged flexible polyamine chains and a semi-rigid charged piperazine linker. Their cytotoxicity towards human leukaemic cells gives IC(50) values ranging from 99 to 1100 nM, with the ethylpiperidino series generally being more cytotoxic than the N-methylpiperidin-4-yl series. Measurements with supercoiled DNA indicate that they bisintercalate. Topics: Aminoacridines; Cell Cycle; Cell Line, Tumor; Dimerization; DNA; Humans; Molecular Structure; Piperidines; Structure-Activity Relationship	2008

Article

Year

DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest.

Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8

We describe the synthesis of a series of DNA-threading bis(9-aminoacridine-4-carboxamides) comprising ethylpiperidino and N-methylpiperidin-4-yl sidechains, joined via neutral flexible alkyl chains, charged flexible polyamine chains and a semi-rigid charged piperazine linker. Their cytotoxicity towards human leukaemic cells gives IC(50) values ranging from 99 to 1100 nM, with the ethylpiperidino series generally being more cytotoxic than the N-methylpiperidin-4-yl series. Measurements with supercoiled DNA indicate that they bisintercalate.

Topics: Aminoacridines; Cell Cycle; Cell Line, Tumor; Dimerization; DNA; Humans; Molecular Structure; Piperidines; Structure-Activity Relationship

2008