piperidines has been researched along with 7-alpha-hydroxy-4-cholesten-3-one* in 1 studies
1 other study(ies) available for piperidines and 7-alpha-hydroxy-4-cholesten-3-one
| Article | Year |
|---|---|
Antidyslipidemic potential of a novel farnesoid X receptor antagonist in a hamster model of dyslipidemia: Comparative studies of other nonstatin agents.
We attempted to clarify the therapeutic capability of antagonists of the farnesoid X receptor (FXR), a nuclear receptor that regulates lipid and bile acid metabolism. Herein, we report the antidyslipidemic effects of a novel synthesized FXR antagonist, compound-T1, utilizing a dyslipidemic hamster model. Compound-T1 selectively inhibited chenodeoxycholic acid-induced FXR activation (IC Topics: Animals; Apolipoprotein A-I; Benzoates; Bile Acids and Salts; Cell Line, Tumor; Cholestenones; Cholesterol; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dyslipidemias; Feces; Humans; Hypolipidemic Agents; Lipid Metabolism; Male; Mesocricetus; Piperidines; Receptors, Cytoplasmic and Nuclear; Triglycerides | 2018 |