piperidines has been researched along with 6-hydroxy-2-5-7-8-tetramethylchroman-2-carboxylic-acid* in 2 studies
2 other study(ies) available for piperidines and 6-hydroxy-2-5-7-8-tetramethylchroman-2-carboxylic-acid
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Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.
A novel series of donepezil-trolox hybrids were designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD). Biological assays showed that these derivatives possessed moderate to good inhibitory activities against acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) as well as remarkable antioxidant effects. The optimal compound 6d exhibited balanced functions with good inhibition against hAChE (IC Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Central Nervous System Agents; Chelating Agents; Cholinesterase Inhibitors; Chromans; Copper; Donepezil; Drug Design; Drug Evaluation, Preclinical; Humans; Indans; Male; Mice, Inbred ICR; Microglia; Molecular Docking Simulation; Monoamine Oxidase Inhibitors; Neurotoxins; Oxidants; PC12 Cells; Peptide Fragments; Piperidines; Protein Aggregation, Pathological; Rats; Structure-Activity Relationship | 2017 |
Death of cerebellar granule neurons induced by piperine is distinct from that induced by low potassium medium.
We compared neurotoxicity of piperine and low K+ on cultured cerebellar granule neurons. As considered from lactate dehydrogenase release and 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide reduction, both piperine and shifting from high K+ (25 mM) to low K+ (5.4 mM) were cytotoxic to cerebellar granule neurons. Protein synthesis inhibitors, cycloheximide and anisomycin, and an endonuclease inhibitor, aurintricarboxylic acid, were protective against low K+-induced neuronal death whereas they were ineffective against that induced by piperine. D-alpha-tocopherol, trolox, and a spin trap 3,3,5,5-tetramethyl-1-pyrroline-1-oxide were protective against piperine neurotoxicity whereas they had no effect on that induced by low K+. These results suggest that piperine and low K+ may exert neurotoxic effects on cerebellar granule neurons through different mechanisms. Death of cerebellar granule neurons induced by piperine may be mediated by non-apoptotic mechanisms and may involve membrane lipid peroxidation and/or free radical generation. Topics: Alkaloids; Animals; Anisomycin; Aurintricarboxylic Acid; Benzodioxoles; Cell Death; Cells, Cultured; Cerebellum; Chromans; Cyclic N-Oxides; Cycloheximide; Free Radical Scavengers; Kinetics; L-Lactate Dehydrogenase; Neurons; Piperidines; Polyunsaturated Alkamides; Potassium; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Spin Labels; Vitamin E | 1998 |