piperidines and 6-deacetylnimbin

piperidines has been researched along with 6-deacetylnimbin* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 6-deacetylnimbin

Article	Year
A piperidine alkaloid and limonoids from Arisaema decipiens, a traditional antitumor herb used by the Dong people. Archives of pharmacal research, 2010, Volume: 33, Issue:11 A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R,3S,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC₅₀ value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine. Topics: Alkaloids; Antineoplastic Agents; Arisaema; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Ethnicity; Female; Humans; Limonins; Magnetic Resonance Imaging; Ovarian Neoplasms; Piperidines; Rhizome	2010

Article

Year

A piperidine alkaloid and limonoids from Arisaema decipiens, a traditional antitumor herb used by the Dong people.

Archives of pharmacal research, 2010, Volume: 33, Issue:11

A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC₅₀ value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine.

Topics: Alkaloids; Antineoplastic Agents; Arisaema; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Ethnicity; Female; Humans; Limonins; Magnetic Resonance Imaging; Ovarian Neoplasms; Piperidines; Rhizome

2010