piperidines and 4-iododexetimide

piperidines has been researched along with 4-iododexetimide* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 4-iododexetimide

Article	Year
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 A series of halogenated racemic analogues of dexetimide (1) was synthesized and their affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide (21), was efficiently labeled with 125I and 123I at high specific activity. In vitro binding studies and in vivo biodistribution studies suggest that 123I-labeled 21 may be useful for imaging muscarinic cholinergic receptors in the living human brain with single photon emission computed tomography. Topics: Animals; Dexetimide; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Parasympatholytics; Piperidines; Receptors, Muscarinic; Tomography, Emission-Computed	1989

Article

Year

Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.

Journal of medicinal chemistry, 1989, Volume: 32, Issue:5

A series of halogenated racemic analogues of dexetimide (1) was synthesized and their affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide (21), was efficiently labeled with 125I and 123I at high specific activity. In vitro binding studies and in vivo biodistribution studies suggest that 123I-labeled 21 may be useful for imaging muscarinic cholinergic receptors in the living human brain with single photon emission computed tomography.

Topics: Animals; Dexetimide; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Parasympatholytics; Piperidines; Receptors, Muscarinic; Tomography, Emission-Computed

1989