piperidines has been researched along with 3-hydroxypyridine* in 1 studies
1 other study(ies) available for piperidines and 3-hydroxypyridine
| Article | Year |
|---|---|
Metal-free decarboxylative hetero-Diels–Alder synthesis of 3-hydroxypyridines: a rapid access to N-fused bicyclic hydroxypiperidine scaffolds.
A complete experimental and theoretical study of the thermally controlled metal-free decarboxylative hetero-Diels–Alder (HDA) reaction of 5-alkoxyoxazoles with acrylic acid is reported. This strategy offers a new entry to valuable 2,6-difunctionalized 3-hydroxypyridines from readily available 2- and 4-disubstituted 5-alkoxyoxazoles. The reaction conditions proved compatible with, among others, ketone, amide, ester, ether, and nitrile groups. The broad functional group tolerance of the protocol allows a rapid and versatile access to both hydroxyindolizidine and hydroxyquinolizidine derivatives via a pyridine dearomatization strategy. Topics: Cycloaddition Reaction; Indolizidines; Metals; Molecular Structure; Piperidines; Pyridines; Pyrimidines; Quinolizidines; Stereoisomerism | 2014 |