piperidines and 3-azabicyclo(3.1.0)hexane

piperidines has been researched along with 3-azabicyclo(3.1.0)hexane* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 3-azabicyclo(3.1.0)hexane

Article	Year
Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors. Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14 The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P(2) region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure-activity relationship, and selectivity against related proteases are delineated. Topics: Amino Acid Motifs; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Hexanes; Humans; Ligands; Models, Chemical; Molecular Conformation; Piperidines; Protease Inhibitors; Structure-Activity Relationship; T-Lymphocytes	2008

Article

Year

Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors.

Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14

The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P(2) region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure-activity relationship, and selectivity against related proteases are delineated.

Topics: Amino Acid Motifs; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Hexanes; Humans; Ligands; Models, Chemical; Molecular Conformation; Piperidines; Protease Inhibitors; Structure-Activity Relationship; T-Lymphocytes

2008