piperidines and 2-methoxynaphthalene

piperidines has been researched along with 2-methoxynaphthalene* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 2-methoxynaphthalene

Article	Year
Synthesis of carbon-11-labeled piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as new selective PET sigma1 receptor probes. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2010, Volume: 68, Issue:3 Carbon-11-labeled piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives were first designed and synthesized as new selective PET sigma(1) receptor probes. The target tracers were prepared by O-[(11)C]methylation of their corresponding phenolic hydroxyl precursors using [(11)C]CH(3)OTf under basic conditions and isolated by a simplified SPE method in 40-50% radiochemical yields based on [(11)C]CO(2) and decay corrected to EOB. The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at EOS was 111-185 GBq/micromol. Topics: Carbon Radioisotopes; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Naphthalenes; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, sigma; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization	2010

Article

Year

Synthesis of carbon-11-labeled piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as new selective PET sigma1 receptor probes.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2010, Volume: 68, Issue:3

Carbon-11-labeled piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives were first designed and synthesized as new selective PET sigma(1) receptor probes. The target tracers were prepared by O-[(11)C]methylation of their corresponding phenolic hydroxyl precursors using [(11)C]CH(3)OTf under basic conditions and isolated by a simplified SPE method in 40-50% radiochemical yields based on [(11)C]CO(2) and decay corrected to EOB. The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at EOS was 111-185 GBq/micromol.

Topics: Carbon Radioisotopes; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Naphthalenes; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, sigma; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization

2010