piperidines has been researched along with 2-5-dihydroxymethyl-3-4-dihydroxypyrrolidine* in 1 studies
1 other study(ies) available for piperidines and 2-5-dihydroxymethyl-3-4-dihydroxypyrrolidine
| Article | Year |
|---|---|
Synthesis of azasugars as potent inhibitors of glycosidases.
A series of enantiomerically pure azasugars (2,5-dideoxy-2, 5-imino-D-mannitol, 1-deoxynojirimycin, 1-deoxymannojirimycin, and related compounds) was synthesized from D-mannitol via aminoheterocyclization of C2-symmetric bis-epoxides and subsequently followed by ring isomerization in few cases. These compounds have been evaluated as inhibitors of several glycosidases (alpha- and beta-D-glucosidases, alpha-D-mannosidase and alpha-L-fucosidase). Inhibition studies indicate notably that the polyhydroxylated azepanes are inhibitors of glycosidases, with Ki in the micromolar range. Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Cattle; Enzyme Inhibitors; Geobacillus stearothermophilus; Glycoside Hydrolase Inhibitors; Glycoside Hydrolases; Imino Furanoses; Isomerism; Kidney; Kinetics; Mannitol; Models, Chemical; Piperidines; Pyrrolidines | 1997 |