piperidines and 13-hydroxy-9-11-octadecadienoic-acid

piperidines has been researched along with 13-hydroxy-9-11-octadecadienoic-acid* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 13-hydroxy-9-11-octadecadienoic-acid

ArticleYear
Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid.
    FEBS letters, 1984, Jul-09, Volume: 172, Issue:2

    The breakage of double-strand (ds) DNA by 13-L-hydroperoxy-cis-9,trans-11-octadecadienoic acid (LAHPO) was investigated by agarose gel electrophoresis of supercoiled pBR322 DNA and the site of cleavage on the DNA molecule was determined by the method of DNA sequence analysis using 3'-end and 5'-end-labeled DNA fragments as substrates. LAHPO caused cleavage at the position of guanine nucleotide in dsDNA. LAHPO caused dsDNA breaks at specific sites, but linoleic acid (LA) and 13-L-hydroxy-cis-9,trans-11-octadecadienoic acid (LAHO) have no such effects on dsDNA. The active oxygen atom of the hydroperoxy group of LAHPO was perhaps responsible for the site-specific cleavage of dsDNA.

    Topics: Animals; DNA, Superhelical; Drosophila melanogaster; Linoleic Acid; Linoleic Acids; Lipid Peroxides; Piperidines; Plasmids

1984