piperidines and 1-aminoisoquinoline

piperidines has been researched along with 1-aminoisoquinoline* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 1-aminoisoquinoline

Article	Year
1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors. Bioorganic & medicinal chemistry letters, 1999, Mar-08, Volume: 9, Issue:5 Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability. Topics: Administration, Oral; Anticoagulants; Benzamidines; Caco-2 Cells; Dipeptides; Drug Design; Humans; Isoquinolines; Piperidines; Thrombin; Trypsin Inhibitors	1999

Article

Year

1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors.

Bioorganic & medicinal chemistry letters, 1999, Mar-08, Volume: 9, Issue:5

Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability.

Topics: Administration, Oral; Anticoagulants; Benzamidines; Caco-2 Cells; Dipeptides; Drug Design; Humans; Isoquinolines; Piperidines; Thrombin; Trypsin Inhibitors

1999