piperidines and 1-8-diazabicyclo(5.4.0)undec-7-ene

piperidines has been researched along with 1-8-diazabicyclo(5.4.0)undec-7-ene* in 1 studies

Other Studies

1 other study(ies) available for piperidines and 1-8-diazabicyclo(5.4.0)undec-7-ene

Article	Year
The aspartimide problem in Fmoc-based SPPS. Part II. Journal of peptide science : an official publication of the European Peptide Society, 2003, Volume: 9, Issue:8 The sequence dependence of base-catalysed aspartmide formation during Fmoc-based SPPS was systematically studied employing the peptide models H-Val-Lys-Asp-Xaa-Tyr-Ile-OH. The extent of formation of aspartimide and related by-products was determined by RP-HPLC. Considerable amounts of by-products were formed in the case of Xaa = Asp(OtBu), Arg(Pbf), Asn(Mtt), Cys(Acm) and unprotected Thr. Aspartimide formation could be diminished by incorporation of Asp(OMpe) or by employing milder methods for Fmoc cleavage, e.g. hexamethyleneimine/N-methylpyrrolidine/HOBt/NMP/DMSO 4:50:4:71:71 (v/v/w/v/v). Topics: Amino Acids; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Fluorenes; Peptide Biosynthesis; Peptides; Piperidines	2003

Article

Year

The aspartimide problem in Fmoc-based SPPS. Part II.

Journal of peptide science : an official publication of the European Peptide Society, 2003, Volume: 9, Issue:8

The sequence dependence of base-catalysed aspartmide formation during Fmoc-based SPPS was systematically studied employing the peptide models H-Val-Lys-Asp-Xaa-Tyr-Ile-OH. The extent of formation of aspartimide and related by-products was determined by RP-HPLC. Considerable amounts of by-products were formed in the case of Xaa = Asp(OtBu), Arg(Pbf), Asn(Mtt), Cys(Acm) and unprotected Thr. Aspartimide formation could be diminished by incorporation of Asp(OMpe) or by employing milder methods for Fmoc cleavage, e.g. hexamethyleneimine/N-methylpyrrolidine/HOBt/NMP/DMSO 4:50:4:71:71 (v/v/w/v/v).

Topics: Amino Acids; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Fluorenes; Peptide Biosynthesis; Peptides; Piperidines

2003