piperidines and 1-(3-trifluoromethylphenyl)-2-propanol

Using a standard two-lever drug discrimination procedure, twelve rats were trained to discriminate 1.0 mg/kg of the serotonin (5-HT) agonist TFMPP from saline. Once trained, the animals displayed a dose-related decrease in discriminative performance upon administration of lower doses of TFMPP. Tests of stimulus generalization were performed using the purported 5-HT agonist RU-24, 969 and 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM). While TFMPP produced stimulus effects similar to those of RU-24,969, these effects seem to be dissimilar to those of DOM. The results of the present study suggest that the discriminative stimulus effects of TFMPP may involve a 5-HT1-related mechanism.

Topics: Animals; Discrimination Learning; DOM 2,5-Dimethoxy-4-Methylamphetamine; Extinction, Psychological; Fenfluramine; Indoles; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Serotonin