piperidine has been researched along with piperidines in 759 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 155 (20.42) | 18.7374 |
| 1990's | 59 (7.77) | 18.2507 |
| 2000's | 196 (25.82) | 29.6817 |
| 2010's | 292 (38.47) | 24.3611 |
| 2020's | 57 (7.51) | 2.80 |
| Authors | Studies |
|---|---|
| Murad, S; Pinnell, SR; Tennant, MC | 1 |
| Chung, MH; Kasai, H; Kiyosawa, H; Nishimura, S; Ohtsuka, E | 1 |
| Choughuley, AS; Shenoy, NR | 1 |
| Armiger, YL; Baker, WR; Boyd, SA; Cohen, J; Condon, SL; Dayton, BD; Fung, AK; Mantei, RA; Rosenberg, SH; Stein, HH | 1 |
| Anderson, MW; Glickman, BW; Shoukry, S | 1 |
| Pless, RC; Testoff, MA | 1 |
| Jelen, F; Karlovský, P; Makaturová, E; Palecek, E; Pecinka, P | 1 |
| Asseline, U; Bisagni, E; Hélène, C; Le Doan, T; Perrouault, L; Rivalle, C; Thuong, NT | 1 |
| Klee, MR; Takahama, K | 2 |
| Lebowitz, J; Sullivan, JK | 1 |
| Cheng, Y; Dahlberg, JE; Htun, H; Tang, MS | 1 |
| Martin, CT; Prigodich, RV | 1 |
| Fellows, LE; Nash, RJ | 1 |
| Abramova, TV; Frolova, EI; Ivanova, EM; Vlassov, VV; Zarytova, VF | 1 |
| Boyer, V; Helene, C; Helland, DE; Kittler, L; Le Doan, T; Moustacchi, E; Sage, E | 1 |
| Eadie, JS; Farrance, IK; Ivarie, R | 1 |
| Cotton, RG; Wright, PJ | 1 |
| Kasé, Y; Miyata, T; Okano, Y; Takahama, K | 1 |
| Pinder, AR | 1 |
| Jost, JP; Saluz, H | 1 |
| Shi, YG; Tyler, BM | 1 |
| Ambrose, BJ; Ayers, ME; Pless, RC | 1 |
| Horton, RC; Logan, SD; Wolstencroft, JH | 1 |
| Chang, YF; Myslinski, NR | 1 |
| Duplaa, AM; Téoule, R | 1 |
| Leng, M; Malfoy, B; Marrot, L; Rousseau, N; Vogt, N | 1 |
| Krueger, WC; Li, LH; Petzold, GL; Prairie, MD; Swenson, DH; Williams, MG | 1 |
| Hemminki, K; Vodicka, P | 1 |
| Fedorova, OS; Knorre, DG; Podust, LM; Zarytova, VF | 1 |
| Akaike, N; Hashimoto, T; Kaisaku, J; Kase, Y; Miyata, T; Okano, Y; Satoh, K; Takahama, K | 1 |
| Dervan, PB; Iverson, BL | 1 |
| Barthalmus, GT; Mitchell, MK; Noga, EJ | 1 |
| Hartley, JA; Kohn, KW; Mattes, WB | 1 |
| Hayashi, E; Kagawa, Y; Takayanagi, N; Ushijima, H; Yamada, S | 1 |
| Ambrose, BJ; Castro, MM; Pless, RC | 1 |
| Ishino, S; Kamiya, S; Miyahara, M; Sueyoshi, S; Tanno, M | 1 |
| Budowsky, EI; Kovalsky, OI; Rubin, LB; Simukova, NA | 1 |
| Eremin, AN; Metelitsa, DI | 1 |
| Giacobini, E; Nomura, Y; Ortiz, J; Schmidt-Glenewinkel, T | 1 |
| Inouye, S | 1 |
| Buchko, GW; Cadet, J; Morin, B; Weinfeld, M | 1 |
| Atawodi, SE; Mende, P; Pfundstein, B; Preussmann, R; Spiegelhalder, B | 1 |
| Driomina, ES; Gashev, SB; Reznitchenko, AV; Sharov, VS; Vladimirov, YA | 1 |
| Baeuerle, PA; Büning, H; Zorbas, H | 1 |
| Jollès, B; Laigle, A | 1 |
| Jost, JP; Saluz, HP | 1 |
| Freudenreich, CH; Kreuzer, KN | 1 |
| Barlati, S; Di Mauro, E; Ferraboli, S; Negri, R | 1 |
| Pichersky, E | 1 |
| Balcarová, Z; Boudný, V; Brabec, V | 1 |
| Goldberg, IH; Kappen, LS | 1 |
| Papavassiliou, AG; Smith, SE | 1 |
| Cotton, RG; Saleeba, JA | 1 |
| Smith, CA; Taylor, JS | 1 |
| Bourinet, E; Snutch, TP; Soong, TW; Zamponi, GW | 1 |
| Dervan, PB; Grant, KB | 1 |
| Michida, M; Mitsunobu, O; Ogawa, A; Sakagami, K; Yamaga, H | 1 |
| Cotton, RG; Ramus, SJ | 1 |
| Karlström, A; Undén, A | 1 |
| Ammini, CV; Ghivizzani, SC; Hauswirth, WW; Madsen, CS; Nelen, MR | 1 |
| Gallard, JF; Guittet, E; Le, HT; Mayer, M; Michelot, R | 1 |
| Andersen, P; Batz, HG; Hansen, HF; Koch, T; Larsen, T; Orum, H; Otteson, K | 1 |
| DeGrado, WF; Jackson, S; Mousa, S; Olson, RE; Rafalski, M; Rockwell, A; Roderick, J; Xue, CB | 1 |
| Besse, P; Combourieu, B; Delort, AM; Poupin, P; Sancelme, M; Truffaut, N; Veschambre, H | 1 |
| Augustyns, K; Jung, G; Kraas, W | 1 |
| Briand, JP; Dalbon, P; Jolivet, M; Limal, D | 1 |
| Aritake, K; Hayashi, K; Hayashi, M; Hirotsu, I; Hizue, M; Kimura, Y; Matsushita, N; Mitsui, K; Nakajima, H; Takada, A; Tani, T | 2 |
| Zamponi, GW | 1 |
| Bourdat, AG; Cadet, J; Gasparutto, D | 1 |
| Haworth, IS; Mitas, M; Romero, RM | 1 |
| Kawanishi, S; Ohkuma, Y | 1 |
| Kasai, H; Kawamura, M; Kohno, K; Nomoto, M; Yamaguchi, R | 1 |
| Adang, AE; de Zwart, E; Gerritsma, S; Peters, AM; Veeneman, G | 1 |
| Bonner, K; Carling, RW; Emms, F; Jones, EA; Leeson, PD; Marwood, R; Moore, KW; Patel, S; Rowley, M; Thomas, S | 1 |
| Ducrocq, V; Hallier-Soulier, S; Poupin, P; Truffaut, N | 1 |
| Godon, JJ; Poupin, P; Truffaut, N; Zumstein, E | 1 |
| Bourdat, AG; Cadet, J; Da Cruz, S; Gasparutto, D; Jaquinod, M | 1 |
| Akahane, A; Durkin, K; Itani, H; Kinoshita, T; Kuroda, S; Nishimura, S; Sakane, K; Tenda, Y | 1 |
| Liang, GB; Qian, X | 1 |
| Billah, MM; Carruthers, NI; Chan, TM; Kaminski, JJ; McPhail, AT; Tozzi, S; Wong, SC | 1 |
| Greenberg, MM; Hwang, JT; Tallman, KA | 1 |
| Bendesky, R; Broten, TP; Chang, RS; Chen, TB; Chiu, G; Forray, C; Harrell, CM; Lagu, B; Marzabadi, MR; Miao, SW; Murali Dhar, TG; Nagarathnam, D; O'Malley, S; Ransom, R; Schneck, K; Schorn, TW; Shen, Q; Sun, W; Tian, D; Tyagarajan, S; Vyas, KP; Wetzel, JM; Wong, WC; Zhang, F; Zhang, J | 1 |
| Abdel-Rahman, LH; Belal, AA | 1 |
| Deslippe, RJ; Guo, YJ | 1 |
| Laval, J; Mani, JC; Saparbaev, M | 1 |
| Hiraku, Y; Kawanishi, S; Murata, M; Ohnishi, S; Oikawa, S | 1 |
| Kispert, LD; Konovalova, TA; Leshina, TV; Polyakov, NE | 1 |
| Andreesen, JR; Schräder, T; Schuffenhauer, G; Sielaff, B | 1 |
| Lee, CS; O'Connor, TR; Pfeifer, GP; Yasui, A; Yoon, JH | 1 |
| Ait-Abbas, M; Boiteux, S; Cadet, J; Gasparutto, D; Jaquinod, M | 1 |
| Tannenbaum, SR; Tretyakova, NY; Wishnok, JS | 1 |
| Acero, JL; Canonica, S; Eggen, RI; Schweigert, N; von Gunten, U; Zehnder, AJ | 1 |
| Mann, JR; Miao, F; O'Connor, TR; Pfeifer, GP; Szabó, PE | 1 |
| Gan, YD; Lytle, CA; White, DC | 1 |
| Fendt, M | 1 |
| Burrows, CJ; Meunier, B; Pitié, M | 1 |
| Hasegawa, S; Hirota, TK; Komoto, T; Kotake, J; Koya, H; Otsuka, M; Sakamoto, T; Sato, S | 1 |
| Driouich, R; Motomizu, S; Oshima, M; Takayanagi, T | 1 |
| Castonguay, A; Cloutier, JF; Drouin, R; O'Connor, TR | 1 |
| Clarke, SR; Dyke, KG | 1 |
| Barton, JK; Dill, EA; Odom, DT | 1 |
| Belotti, D; Cossy, J | 1 |
| Feighner, SD; Howard, AD; Hreniuk, DL; McKee, KK; Nargund, RP; Palucki, BL; Patchett, AA; Pong, S; Tan, C; Van der Ploeg, LH | 1 |
| Choi, JY; Chung, MH; Doetsch, PW; Kim, JE; Kim, JS; You, HJ | 1 |
| Hopkins, PB; Luce, RA | 1 |
| Angers, M; Castonguay, A; Cloutier, JF; Drouin, R | 1 |
| Ishida, Y; Kohno, T; Nakamura, H; Nakamura, M; Niwa, Y; Oba, Y; Sato, K | 1 |
| Johnson, KJ; Kozikowski, AP; Petukhov, PA; Tella, SR; Zhang, M | 1 |
| Castonguay, L; DeMartino, JA; Finke, PE; Gould, SL; Loebach, JL; MacCoss, M; Malkowitz, L; Meurer, LC; Mills, SG; Oates, B; Shah, SK; Springer, MS | 1 |
| Felpin, FX; Girard, S; Lebreton, J; Robins, RJ; Villiéras, J; Vo-Thanh, G | 1 |
| Clary, E; Derosier, LC; Ebbinghaus, S; Gorn, V; Kahn, W; Methvin, R; Milesi, D; Reed, M; Song, CY; Ziemba, A | 1 |
| Brechbiel, MW; Bryant, LH; Chong, HS; Garmestani, K | 1 |
| Ahn, YH; Yoo, JS | 1 |
| Kawanishi, S; Ohnishi, S | 1 |
| Callado, LF; Girón, R; Goicoechea, C; Goya, P; Jagerovic, N; Martín, MI; Meana, JJ; Montero, A | 1 |
| Kawanishi, S; Murata, M; Ohnishi, S | 1 |
| David, WM; Kerwin, SM; Kumar, D; Salazar, M; Tuntiwechapikul, W | 1 |
| Gerson, EA; Kelsey, RG | 1 |
| Canary, JW; Dai, Z; Xu, X | 1 |
| Bae, HS; Cho, YG; Kim, IS; Lee, JM; Lee, ST; Oh, SE | 1 |
| Köhler, H; Maurelli, AT; McCormick, BA; Rodrigues, SP | 1 |
| Das, MM; Lalitha, M; Murthy, BN; Prabhakar, T; Rao, GB; Rao, NS | 1 |
| Farrell, N; Gibson, D; Moshel, O; Najajreh, Y; Peleg-Shulman, T | 1 |
| Aoshima, M; Hirakawa, K; Hiraku, Y; Kawanishi, S | 1 |
| Berk, S; Budhu, RJ; Caldwell, CG; Carella, A; Carver, G; Cascieri, MA; Chapman, KT; Chen, L; Chen, P; Danzeisen, R; DeMartino, JA; Emini, EA; Gentry, AL; Gould, SL; Hale, JJ; Hazuda, D; Holmes, K; Holson, EJ; Kessler, J; Lineberger, J; Lynch, CL; MacCoss, M; Malkowitz, L; Miller, M; Mills, SG; Rosauer, KG; Schleif, WA; Siciliano, SJ; Springer, MS; Willoughby, CA | 1 |
| Babon, JJ; Bui, CT; Cotton, RG; Lambrinakos, A | 1 |
| Cheng, GB; Dai, JY; Gong, GL; Hu, JH | 1 |
| Kunz, H; Zech, G | 1 |
| Flau, K; Kathmann, M; Liedtke, S; Meier, G; Schlicker, E; Schunack, W; Stark, H | 1 |
| Razskazovskiy, Y | 1 |
| Dixon, HB; Dragoni, S; Frosini, M; Machetti, F; Palmi, M; Sesti, C; Sgaragli, G; Valoti, M | 1 |
| Poupin, P; Pulvin, S; Thomas, D; Trigui, M | 1 |
| Kim, KH; Kim, KM; Song, R | 1 |
| Dick, F; Mergler, M; Sax, B; Stähelin, C; Vorherr, T | 1 |
| Brabec, V; Gibson, D; Kasparkova, J; Marini, V; Najajreh, Y; Novakova, O; Perez, JM | 1 |
| OTTAVIANO, G | 2 |
| KLOSA, J | 1 |
| FRICK, H; LUTZ, AH; SCHNIDER, O | 1 |
| CASTORINA, G; PRATESI, P | 3 |
| HOFFMANN, K; SURY, E; TRIPOD, J | 1 |
| KEASLING, HH; LONG, JP | 1 |
| GRANA, E | 1 |
| KEMPER, H | 1 |
| SCHMITT, W | 1 |
| BELLUCCI, G | 1 |
| GYERMEK, L | 1 |
| MANN, PJ; SMITHIES, WR | 1 |
| VANECEK, M; VOTAVA, Z | 1 |
| VILLA, L | 1 |
| CAVIER, R; GAULIN, J | 1 |
| KOLOWRAT, F | 1 |
| DAURI, A; GALLOZZI, E | 1 |
| SCHNEIDER, W | 1 |
| STEWART, JS | 1 |
| LANDI-VITTORY, R | 1 |
| SIMON, I | 5 |
| MAZZOLENI, G; VANGELISTA, G | 1 |
| CAMERA, A; DE GAETANI, G; VANGELISTA, G | 1 |
| NAPOLI, MD; O'DELL, TB | 1 |
| GIANNIOTTI, G; GIBERTI, F; SPIZZIRRI, S | 1 |
| BLAZEK, J; STEJSKAL, Z | 1 |
| CAVALLINI, G; GRASSO, I; GRUMELLI, E; MILLA, E; RAVENNA, F | 1 |
| ZINNER, G | 1 |
| BOHNEL, J; STACHER, A | 1 |
| GARDENGHI, G; SCOLARI, EG | 1 |
| VON HAXTHAUSEN, EF; WOLF, A | 1 |
| DOFEK, R; VRBA, C | 1 |
| CLARKE, AJ; MANN, PJ | 1 |
| CHISALE, E; VALLERINO, V | 1 |
| BERRY, C; BURKHALTER, A; DAVIS, LW; GROSS, EG; KEASLING, HH | 1 |
| ABOOD, LG; EAGLETON, V; RINALDI, F | 1 |
| BOHNER, B; CHEN, G | 1 |
| GROSSI-BIANCHI, ML | 1 |
| DECKERT, M; PROFFT, E | 1 |
| BOHNER, B; CHEN, G; ENSOR, CR; RUSSELL, D | 1 |
| BIAZSO, S | 1 |
| BINIECKI, S; MODRZEJEWSKA, W | 1 |
| MOLL, F | 1 |
| BARBI, G | 1 |
| BOULANGER, P; OSTEUX, R; SACQUET, E | 1 |
| KIM, KH | 2 |
| SINISTRI, C; VILLA, L | 1 |
| FISHER, D; HOEKSTRA, JB; MINOR, WF; SAM, J | 1 |
| HASSE, K; SCHMID, G | 1 |
| METYS, J; METYSOVA, J; VOTAVA, Z | 1 |
| BARRERAHERNANDEZ, EU | 1 |
| MASKOVSKIJ, MD; MICHLINA, EE; NIKITSKAJA, ES; RUBCOV, MV; SARAPOV, IM; USOVSKAJA, VS; VOROBJEVA, VJ | 1 |
| COHEN, MP; SHAVEL, J; VONSTRANDTMANN, M | 1 |
| FINK, GB; JUCHAU, MR | 1 |
| BOULANGER, P; CHARLIER, H; OSTEUX, R; SACQUET, E | 1 |
| HONEGGER, CG; LANGEMANN, HM | 1 |
| LUCKNER, M | 1 |
| BARRE, N; CAHN, J; HEROLD, M | 1 |
| WEISCHEDEL, D; ZIOLKO, HU | 1 |
| KODAMA, M | 1 |
| BECKETT, AH; CASY, AF; YOUSSEF, HZ | 1 |
| ARDILLO, L; MAINARDI, C | 1 |
| ARENDARUK, AP; SKOLDINOV, AP; SOLOVEV, VM | 1 |
| HADER, M; SCHULMAN, PM | 1 |
| BARBARA, A; CUGURRA, F; PAPADIA, S | 1 |
| KASUGA, S; TAGUCHI, T | 1 |
| CUGURRA, F; FERRO, M; VACCARI, A | 1 |
| IMAMURA, H; TAKAGI, K; TAKAYANAGI, I | 1 |
| COMBES, FC; REISCH, M | 1 |
| BRANDMAN, O; CONIARIS, J; KELLER, HE | 1 |
| JURGENS, R; PELLMONT, B; STUDER, A | 1 |
| AITKEN, RC; CAMERON, DE; LEVY, L | 1 |
| LISTER, RE | 1 |
| PRIBILLA, O | 1 |
| RAYMOND-HAMET, M | 1 |
| Santhosh, U; Schuster, GB | 1 |
| Chen, KH; Liao, WS; Lin, CE; Lin, WY | 1 |
| Järvinen, T; Niemi, R; Peräkylä, M; Turhanen, PA; Vepsäläinen, JJ | 1 |
| Brabec, V; Gibson, D; Kasparkova, J; Najajreh, Y; Novakova, O; Perez, JM | 1 |
| Billard, W; Binch, H; Chen, LY; Clader, JW; Crosby, G; Duffy, RA; Ford, J; Greenlee, WJ; Kozlowski, JA; Lachowicz, JE; Li, S; Liu, C; McCombie, SW; Vice, S; Zhou, G | 1 |
| MALL, G; VOSSELER, E | 1 |
| ANDERSSON, NE; SOINE, TO | 2 |
| BACHMANN, RO; JENKINS, GL | 1 |
| PETERSEN, PV | 1 |
| LAVIGNE, R; LEMAY, L; MARION, L | 1 |
| NORDENSTROM, BE | 2 |
| KRAUSHAAR, A | 1 |
| PFLANZ, C | 1 |
| LaFORGE, HG | 1 |
| DUNER, H; PERNOW, B | 1 |
| BUCHDAHL, MR; SOINE, TO | 1 |
| Ito, T; Rokita, SE | 1 |
| Borisova, TN; Kulikova, LN; Soklakova, TA; Varlamov, AV; Voskressensky, LG | 1 |
| de Jong, H; Feringa, BL; Meetsma, A; ter Wiel, MK; van Delden, RA | 1 |
| Caldwell, CG; Carella, A; Carver, G; Chen, P; Danzeisen, R; DeMartino, JA; Donnelly, KL; Emini, EA; Finke, PE; Gould, SL; Hazuda, D; Holmes, K; Kessler, J; Kwei, G; Lineberger, J; MacCoss, M; Malkowitz, L; Miller, MD; Mills, SG; Oates, B; Schleif, WA; Shah, SK; Shankaran, K; Siciliano, SJ; Springer, MS | 1 |
| Bedi, PM; Kapoor, VK; Mahajan, MP | 1 |
| Bartoszyk, GD; Böttcher, H; Greiner, HE; Heinrich, T; Seyfried, CA; Van Amsterdam, C | 1 |
| Frederick, ED; Goda, J; Katz, JL; Millard, JT; Pierce, SE; Speed, TJ; Thamattoor, DM | 1 |
| MURGATROYD, F; WOODRUFF, AW | 1 |
| GRUBER, CM; LEE, KS | 1 |
| Arai, Y; Inomata, Y; Scott Howell, F; Yamakoshi, T | 1 |
| Bergeron, F; Houde, D; Hunting, DJ; Wagner, JR | 1 |
| Durgun, M; Emul, M; Innocenti, A; Scozzafava, A; Supuran, CT; Turkmen, H; Vullo, D; Yilmaztekin, S | 1 |
| Angelov, D; Beylot, B; Spassky, A | 1 |
| Goodenough, KM; Harrity, JP; Moran, WJ; Raubo, P | 1 |
| Casely-Hayford, MA; Gerner, C; Neidle, S; Patterson, LH; Pors, K; Searcey, M | 1 |
| Alonso, C; Fuertes, MA; Gibson, D; Iborra, S; Martínez, E; Najajreh, Y; Nguewa, PA; Pérez, JM | 1 |
| Burrows, CJ; Johansen, ME; Muller, JG; Xu, X | 1 |
| Allen, HC; Liu, D; Ma, G | 1 |
| Barreiro, EJ; Bolzani, VS; Cabral, RF; Castro, NG; Costa, RS; Floyd, C; Fraga, CA; Pimentel, LS; Rocha, MS; Viegas, C; Young, MC | 1 |
| Ganesh, KN; Kumar, VA | 1 |
| Bhatia, PA; Brioni, JD; Chang, R; Daanen, JF; Hakeem, AA; Kolasa, T; Latsaw, SP; Matulenko, MA; Miller, LN; Moreland, RB; Nakane, M; Rohde, J; Stewart, AO; Uchic, ME; Wang, X | 1 |
| Kim, JY; Mehanna, AS | 1 |
| Arndt, KM; Bernauer, HS; Knall, S; Müller, KM; Stebel, SC; Zipf, G | 1 |
| Cooper, AE; Cumming, JG; Grime, K; Logan, CJ; McLaughlin, S; Oldfield, J; Shaw, JS; Tucker, H; Whittaker, D; Winter, J | 1 |
| Karvembu, R; Kaveri, MV; Natarajan, K; Prabhakaran, R | 1 |
| Brodjian, S; Brune, M; Bush, E; Collins, CA; Dayton, B; Engstrom, KM; Falls, DH; Freeman, JC; Gao, J; Hernandez, LE; Kym, PR; Lynch, JK; Marsh, KC; Mulhern, MM; Shapiro, RD; Souers, AJ; Vasudevan, A; Verzal, MK; Wagaw, SH; Wodka, D | 1 |
| Hirakawa, K; Kawanishi, S; Matsumoto, J; Shiragami, T; Yasuda, M | 1 |
| Alonso, JM; Alvarez, RM; Andrés, JI; Boeckx, I; De Lucas, AI; Fernández, J; Gómez, A; Iturrino, L; Janssens, FE; Leenaerts, JE; Matesanz, E; Meert, T; Pullan, S; Steckler, T; Trabanco, AA | 1 |
| Levins, CG; Schafmeister, CE | 1 |
| Bao, J; Cubbon, RM; Doherty, JB; Hop, CE; Hunt, JA; Kumar, S; Liu, L; Miao, S; O'keefe, SJ; O'neill, EA; Pivnichny, JV; Rupprecht, KM; Ruzek, RD; Shoop, WL; Sinclair, PJ; Stelmach, JE; Thompson, CM; Thompson, JE; Wang, R; Zaller, DM; Zhang, WX | 1 |
| Kumar, S; Nampalli, S; Rao, TS; Xiao, H; Zhang, W | 1 |
| Ballabeni, V; Barocelli, E; Bertoni, S; Bordi, F; Cocconcelli, G; Comini, M; Mor, M; Morini, G; Plazzi, PV; Rivara, M; Rivara, S; Zuliani, V | 1 |
| Jeon, SE; Seok, JA; Um, IH | 1 |
| Bianco, A; D'Ambrosio, A; Franceschin, M; Neidle, S; Ortaggi, G; Rossetti, L; Savino, M; Schirripa, S; Schultes, C | 1 |
| Butler, CR; Edwards, JP; Grice, CA; Gu, Y; Gustin, DJ; Jiang, W; Karlsson, L; Khatuya, H; Sehon, CA; Sun, S; Tays, K; Thurmond, RL; Wei, J | 1 |
| Askew, BC; Biddlecome, G; Biswas, K; Chen, JJ; D'Amico, DC; Fotsch, C; Groneberg, RD; Han, NB; Hsieh, FY; Johnson, E; Kamassah, A; Kumar, G; Lester-Zeiner, D; Liu, Q; Mareska, DA; Ng, G; Riahi, BB; Wang, YJ; Yang, K; Zhan, J; Zhu, J | 1 |
| Dios, R; Fiorentino, A; Gilbert, KM; Misra, M; Pandit, D; Venanzi, CA | 1 |
| Peña, F; Ramirez, JM; Tryba, AK | 1 |
| Goldstein, S; Hideg, K; Merenyi, G; Samuni, A | 1 |
| Armour, DR; Burt, C; de Groot, MJ; Perros, M; Price, DA; Stammen, BL; Wood, A | 1 |
| Kawanishi, S; Kobayashi, H; Oikawa, S | 1 |
| Banerjee, A; Crich, D | 1 |
| Roy, K; Thomas Leonard, J | 1 |
| Kang, UB; Kim, YH; Konishi, K; Lee, C | 1 |
| Augustyns, K; De Meester, I; Haemers, A; Lambeir, AM; Maes, MB; Scharpé, S; Soroka, A; Van der Veken, P | 1 |
| Monguchi, D | 1 |
| Bell, IM; Burgey, CS; Deng, JZ; Graham, SL; Kane, SA; Koblan, KS; Mosser, SD; Nguyen, DN; Norton, BR; Quigley, AG; Rutledge, RZ; Salvatore, CA; Stump, CA; Vacca, JP; Williams, TM | 1 |
| Bergeron, H; Engesser, KH; Kang, I; Kim, SJ; Kim, YH; Lau, PC | 1 |
| Paul, K; Singh, P | 1 |
| Hartman, GD; Jacobson, MA; Lemaire, W; Lindsley, CW; O'Brien, JA; Pettibone, DJ; Smith, S; Sur, C; Tiller, PR; Williams, DL; Wolkenberg, SE; Zhao, Z | 1 |
| Dondoni, A; Nuzzi, A | 1 |
| Ahmed, M; Beller, M; Buch, C; Jackstell, R; Klein, H; Routaboul, L; Spannenberg, A | 1 |
| Campbell, MJ; Johnson, JS | 1 |
| Jamieson, AG; Sutherland, A | 1 |
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| Abbott, JR; Akan, DT; Beesetty, Y; Burns, MC; Daniels, RN; Fesik, SW; Hodges, TR; Howes, JE; Kennedy, JP; Lee, T; Patel, PA; Phan, J; Rossanese, OW; Sai, J; Sobolik, T; Waterson, AG | 1 |
| Gloanec, P; Goument, B; Hanessian, S; Hocine, S; Le Tiran, A; Maertens, G; Mirguet, O; Öney, E; Reyes, MAV; Saavedra, OM; Vece, V | 1 |
| Aso, K; Chisaki, I; Hidaka, K; Kuno, H; Okui, T; Sakauchi, N; Tawaraishi, T; Yoshikawa, K | 1 |
| Alam, MI; Alam, O; Goel, P; Iqbal, M; Naim, MJ; Nawaz, F | 1 |
| Banga, AK; Bhattaccharjee, SA; Blough, BE; Ganti, SS; Murnane, KS | 1 |
| Mamolo, MG; Menegazzi, R; Romano, M; Zampieri, D | 1 |
| Fukuda, T; Hagita, S; Koshizawa, T; Morimoto, T; Ohgiya, T; Okuda, A; Sawada, Y; Shibuya, K; Watanabe, G; Yamasaki, N | 1 |
| Bodnarchuk, MS; Cumming, IA; Degorce, SL; Scott, JS | 1 |
| Barth, VN; Broad, LM; Colvin, EM; Evans, DA; Felder, CC; Goldsmith, PJ; Mogg, AJ; Pasqui, F; Sanger, HE; Sher, E; Wishart, GN; Zwart, R | 1 |
| Chen, H; Jia, W; Jiang, L; Li, W; Pan, G; Shao, L; Shen, J; Xiao, L; Xie, Q; Yan, Y; Yang, X; Yu, H; Yu, L; Yu, M; Zhang, C; Zheng, Y; Zhou, L | 1 |
| Faist, J; Hochegger, P; Kaiser, M; Mäser, P; Saf, R; Seebacher, W; Weis, R | 1 |
| Bai, J; Greenberg, MM; Xi, Z; Zhang, Y; Zhou, C | 1 |
| Bolzani, VDS; Candido, PA; da Silva, CV; Danuello, A; Freitas, TR; Júnior, CV; Lacerda, RBM; Martins, MM; Oliveira, RJ; Pivatto, M; Teixeira, TL | 1 |
| Bigiarini, R; Di Corcia, D; Gerace, E; Palamar, JJ; Salomone, A; Vincenti, M | 1 |
| Amoresano, A; Cilibrizzi, A; Ferraro, G; Merlino, A; Monti, DM; Pane, F; Petruk, G; Pica, A; Vilar, R | 1 |
| Alptuzun, V; Erciyas, E; Holzgrabe, U; Karadagli, SS; Parlar, S; Sayar, G; Tarikogullari, AH | 1 |
| Lan, T; Rao, Y; Su, S; Zhao, Q | 1 |
| Jin, J; Li, K; Xu, L; Zhu, J | 1 |
| Azevedo, V; Barh, D; Ghosh, P; Imchen, M; Jaiswal, AK; Jamal, SB; Kumar, V; Kumavath, RK; Rao, E; Seenivasan, SP; Tiwari, S | 1 |
| Baudoin-Dehoux, C; Castellan, T; Compain, P; Garcia, V; Génisson, Y; Levade, T; Rives, A; Rodriguez, F; Stauffert, F | 1 |
| Chen, WJ; Gong, SS; Han, SB; Huang, HS; Jiang, DH; Sun, Q; Xie, ZB | 1 |
| Artelsmair, M; Bergare, J; Elmore, CS; Kingston, L; Miranda-Azpiazu, P; Schou, M; Varrone, A | 1 |
| Barnes, KD; Blaner, WS; Chen, P; Cioffi, CL; Conlon, MP; Freeman, EE; Johnson, G; Kitchen, DB; Martin, WH; Pearson, PG; Petrukhin, K; Racz, B; Varadi, A; Zhu, L | 1 |
| Abbasi, MA; Aslam, SJ; Rasool, S; Rehman, A; Shah, SAA; Siddiqui, SZ | 1 |
| Che, J; Cheng, G; Dai, X; Dong, X; He, Q; Hu, Y; Jin, Z; Li, J; Shao, Y; Tian, T; Weng, Q; Wu, Y; Xu, L; Yang, B; Zhan, W; Zhao, M; Zhao, Y; Zhou, Y | 1 |
| Balhara, A; Deshpande, AY; Giri, S; Ladumor, MK; Patil, A; Pokharkar, S; Praneetha, P; Preethi, J; Singh, DK; Singh, S | 1 |
| Adhikari, N; Amin, SA; Bobde, Y; Ganesh, R; Ghosh, B; Jha, T; Trivedi, P | 1 |
| Burtea, A; DeForest, J; Li, X; Rychnovsky, SD | 1 |
| Alker, AM; Dolente, C; Fischer, H; Martin, RE; Marty, R; Müller, K; Reinmüller, V; Schnider, P; Stalder, H; Wagner, B; Wyss Gramberg, C | 1 |
| De Luca, L; Garon, A; Germanò, MP; Gitto, R; Ielo, L; Langer, T; Pace, V; Rapisarda, A; Seidel, T; Vittorio, S | 1 |
| Bashetti, N; Damuka, N; Devanathan, S; Mintz, A; Prasanna, B; Seelam, NV; Shanmukha Kumar, JV; Solingapuram Sai, KK | 1 |
| Bajda, M; Godyń, J; Hagenow, S; Kieć-Kononowicz, K; Kuder, K; Malawska, B; Stark, H; Stawarska, E; Zaręba, P; Łątka, K; Łażewska, D | 1 |
| Ballini, E; Carnevale, V; Chen, J; Chernov-Rogan, T; Cridland, AP; Deisemann, H; Gianti, E; Hackos, DH; Hu, X; Klein, ML; Lange, W; Li, T; Liu, C; Magnuson, S; Safina, B; Villemure, E; Volgraf, M; Ward, SI | 1 |
| Bhatti, R; Kaur, J; Kaur, S; Kumari, P; Singh, P | 1 |
| Abiri, A; Asadipour, A; Edraki, N; Eskandari, K; Haghighijoo, Z; Pourshojaei, Y | 1 |
| Aoyama, H; Doura, T | 1 |
| Cavé, C; Cojean, S; Gassama, A; Seck, R | 1 |
| Babin, V; Bouillon, JP; Cailly, T; Davis, A; Dubost, E; Fabis, F; Lohier, JF; Millet, P; Pigrée, G; Reboul, V; Tournier, BB | 1 |
| Chen, Y; Gao, L; Hao, C; Jin, J; Liu, BF; Liu, X; Xiong, J; Zhang, G | 1 |
| Bonandi, E; Passarella, D; Perdicchia, D; Tedesco, G | 1 |
| Fu, W; Li, W; Li, X; Peng, W; Zhao, B; Zhu, C | 1 |
| AlOthman, ZA; Balboni, G; Deplano, A; Moi, D; Nocentini, A; Onnis, V; Osman, SM; Piras, V; Supuran, CT | 1 |
| Harit, VK; Ramesh, NG | 1 |
| Bognár, B; Hideg, K; Isbera, M; Jekő, J; Kálai, T; Sár, C | 1 |
| Hasegawa, Y; Iwaki, H; Liu, Y; Sumiyoshi, T; Yamamoto, T | 1 |
| Cen, S; Dong, B; Ma, L; Wang, J; Wang, Y; Zhang, G; Zhou, H; Zhou, J; Zhu, M | 1 |
| Bai, C; Cheng, H; Gao, Y; Khan, S; Rong, L; Xiao, G | 1 |
| Abe, H; Asawa, Y; Katsuragi, K; Makino, K; Nakamura, H; Nomura, M; Ogino, Y; Okazawa, M; Oyama, T; Sakamoto, Y; Sato, A; Shibasaki, Y; Takahashi, H; Tanuma, N; Tanuma, SI; Uchiumi, F; Yamazaki, H; Yoshimori, A | 1 |
| Chen, Y; Gao, L; Hu, J; Huang, L; Song, T; Yin, L; Zhang, X | 1 |
| Albericio, F; Álvarez, C; Cárdenas, C; Gauna, A; Guzmán, F; Luna, O; Román, T | 1 |
| He, X; Jiao, P; Jin, H; Liu, Z; Wang, K; Wang, X; Yu, B; Zhang, H; Zhang, L; Zhao, S | 1 |
| Darbre, T; Reymond, JL; Zamolo, SJ | 1 |
| Agarwal, S; Asati, V; Bhattacharya, S; Kashaw, SK; Mallick, C; Parwani, D; Rathore, A | 1 |
| Abdullaha, M; Bharate, SB; Nuthakki, VK | 1 |
| Burns, DC; Compadre, CM; Enriquez, RG; Guzman, ML; Jones, DE; Malagón, O; Mery, DE; Nemu, S; Ordóñez, PE; Reynolds, WF; Sharma, KK | 1 |
| Ji, X; Shaw, GX; Shi, G; Tarasov, SG; Zhu, F | 1 |
| Bednarski, M; Bresinsky, M; Elz, S; Höring, C; Karcz, T; Kieć-Kononowicz, K; Kotańska, M; Kuder, KJ; Latacz, G; Mika, K; Mönnich, D; Nagl, M; Pockes, S; Podlewska, S; Seibel, U; Siwek, A; Stark, H; Szczepańska, K | 1 |
| Aissaoui, H; Gnerre, C; Guerry, P; Lehembre, F; Lindenberg, E; Pothier, J; Pouzol, L; Richard-Bildstein, S; Schäfer, G | 1 |
| Liu, S; Lu, W; Lu, X; Qi, J; Wang, X | 1 |
| Mazhukin, DG; Zaytseva, EV | 1 |
| Abbasi, MA; Ali Shah, SA; Aziz-Ur-Rehman, -; Rasool, S; Sattar, A; Siddiqui, SZ | 1 |
| Alexander, R; Espiritu, C; Flores, OA; Hartman, GD; Klumpp, K; Kuduk, SD; Lam, AM; Lau, V; Stoops, B; Vogel, R | 1 |
| Bachman, JL; Dotson, JJ; Garcia-Garibay, MA; Garg, NK; Hipwell, VM; Houk, KN; Khan, SI; Liepuoniute, I | 1 |
| Andrez, JC; Bankar, G; Bergeron, P; Chang, E; Chang, JH; Chen, CA; Chen, J; Chowdhury, S; Cohen, CJ; Dean, R; Decker, SM; Dehnhardt, CM; DiPasquale, A; Focken, T; Hackos, DH; Hemeon, I; Jia, Q; Johnson, JP; Khakh, K; Kim, A; Kwan, R; Li, J; Lin, S; Lindgren, A; Maher, J; McKerrall, SJ; Mezeyova, J; Misner, D; Nelkenbrecher, K; Ortwine, DF; Pang, J; Reese, R; Robinette, CL; Safina, BS; Sheng, T; Shields, SD; Sojo, L; Sun, S; Sutherlin, DP; Verschoof, H; Waldbrook, M; White, AD; Wilson, MS; Xie, Z; Young, C; Zabka, TS; Zenova, AY | 1 |
| Bello, D; Carvalho, S; Chemi, G; Corpas-Lopez, V; Fairlamb, AH; Ferguson, MAJ; Gilbert, IH; Güther, MLS; Martin, J; Moynihan, E; Paradela, LS; Patterson, S; Wall, RJ; Wyllie, S; Zuccotto, F | 1 |
| D'Alonzo, D; De Fenza, M; Esposito, A; Guaragna, A | 1 |
| Calò, S; Cardoso, SM; Chaves, S; Gwizdala, K; Magalhães, JD; Piemontese, L; Queda, F; Santos, MA | 1 |
| Cen, S; Dong, B; Ma, L; Wang, J; Wang, M; Wang, Y; Zhang, G; Zhou, H; Zhou, J; Zhu, M | 1 |
| Dho, Y; Low, YY; Nett, RS; Sattely, ES | 1 |
| Chowdhury, SR; Fu, L; Gu, J; Hu, Y; Jiang, F; Lam, C; Lei, S; Lu, D; Tavallaie, MS; Wang, J | 1 |
| Barravecchia, I; Bononi, G; Caligiuri, I; Demontis, GC; Granchi, C; Macchia, M; Minutolo, F; Poli, G; Rizzolio, F; Tonarini, G; Tuccinardi, T | 1 |
| Chhavi, A; Devkota, HP; Dixit, P; Konar, S; Pandey, S; Saxena, G; Singh, A; Singh, L; Srivastava, RP; Upadhyay, AK; Verma, PC; Yadav, D | 1 |
| Cheng, B; Guo, H; Liu, W; Wang, H; Zhao, Q | 1 |
| Aínsa, JA; Boshoff, HI; Cos, P; Gracia, B; Hulpia, F; Jian, Y; Lucía, A; Merceron, R; Munier-Lehmann, H; Risseeuw, MDP; Savvides, SN; Song, L; Van Calenbergh, S; Verstraelen, T | 1 |
| Cherukupalli, S; De Clercq, E; Feng, D; Fu, Z; Gao, S; Kang, D; Liu, X; Pannecouque, C; Sun, Y; Wang, Z; Zalloum, WA; Zhan, P; Zhang, T; Zhou, Z | 1 |
| Akyıldırım, O; Aras, A; Beytur, M; Boy, S; Manap, S; Sedef Karaman, H; Türkan, F; Yüksek, H | 1 |
| Aparna, P; Bhavani, AKD; Gautier, F; Grée, R; Juin, P; Le Guevel, R; Levoin, N; Mosset, P; Murthy, AVR; Narendar, V; Reddy, CR; Roul, J; Sampath Kumar, N; Solhi, H | 1 |
| Chen, XB; Li, XJ; Liu, HM; Wang, B; Wang, SQ; Yu, B; Zhang, QH | 1 |
| Chen, Y; Hao, C; Liu, BF; Liu, X; Ma, R; Ma, Y; Xiong, J; Xu, J; Ye, J; Zhang, G; Zhang, S; Zhuang, T | 1 |
| Chu, X; Jia, J; Liu, G; Liu, X; Wang, G; Yu, M; Zhao, X | 1 |
| Bennett, J; Dhara, A; Dhara, D; Murphy, PV | 1 |
| Grotemeyer, EN; Jackson, TA; Opalade, AA | 1 |
| Abate, C; Abatematteo, FS; Berardi, F; Brunetti, L; Contino, M; Delprat, B; Laghezza, A; Loiodice, F; Maurice, T; Mosier, PD; Niso, M | 1 |
| Cairns, R; O'Connell, A; O'Reilly, E; Taday, F | 1 |
| Börgel, F; Catapano, CV; Civenni, G; Holtschulte, C; Laurini, E; Marson, D; Pricl, S; Schepmann, D; Westphälinger, S; Wünsch, B | 1 |
| Airinei, A; Deleanu, C; Georgescu, E; Georgescu, F; Isac, DL; Nicolescu, A; Oancea, F; Tigoianu, R | 1 |
| Frolov, NA; Vereshchagin, AN | 1 |
| Bhardwaj, M; Grover, P; Malhotra, A; Mehta, L; Rohilla, S | 1 |
19 review(s) available for piperidine and piperidines
| Article | Year |
|---|---|
[Piperidine in the brain: its neurobiological significance].
Topics: Anesthesia; Animals; Brain; Consciousness; Hibernation; Humans; Neurons; Piperidines; Sleep, REM; Tissue Distribution | 1989 |
Pyrrolidine, piperidine, and pyridine alkaloids.
Topics: Alkaloids; Molecular Structure; Piperidines; Plants; Pyridines; Pyrrolidines | 1989 |
In vivo DNA footprinting by linear amplification.
Topics: Binding Sites; DNA; DNA Damage; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Guanine; Piperidines; Protein Binding; Sequence Analysis, DNA; Sulfuric Acid Esters; Taq Polymerase | 1994 |
[Asymmetric intramolecular conjugate addition of chiral enolates via non-equilibrium].
Topics: Amino Acids; Heterocyclic Compounds; Indoles; Nitrogen Compounds; Piperidines; Pyrrolidines; Stereoisomerism; Tetrahydroisoquinolines | 2006 |
Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives.
Topics: Aza Compounds; Catalysis; Oxidation-Reduction; Piperidines; Stereoisomerism; Thermodynamics | 2011 |
Ghrelin receptor modulators and their therapeutic potential.
Topics: Azoles; Drug Discovery; Ghrelin; Humans; Piperazine; Piperazines; Piperidines; Receptors, Ghrelin; Spiro Compounds; Structure-Activity Relationship | 2009 |
Alkaloids in the human food chain--natural occurrence and possible adverse effects.
Topics: Alkaloids; Carbolines; Diet; Ergot Alkaloids; Food; Food Chain; Humans; Neurotoxins; Ornithine; Piperidines; Pyrrolizidine Alkaloids; Quinolizidines; Risk Assessment; Tropanes | 2012 |
Plant toxins that affect nicotinic acetylcholine receptors: a review.
Topics: Conium; Delphinium; Lupinus; Nicotiana; Nicotinic Agonists; Piperidines; Plants; Receptors, Nicotinic; Toxins, Biological | 2013 |
Plant alkaloids that cause developmental defects through the disruption of cholinergic neurotransmission.
Topics: Alkaloids; Animals; Cholinergic Agents; Humans; Piperidines; Pyridines; Quinolizidines; Receptors, Cholinergic; Structure-Activity Relationship; Synaptic Transmission; Teratogens | 2013 |
Current Drug Discovery for Anti-hepatitis C Virus Targeting NS4B.
Topics: Amides; Animals; Antiviral Agents; Drug Discovery; Hepacivirus; Humans; Piperazines; Piperidines; Quinolines; Sulfonamides; Viral Nonstructural Proteins; Virus Replication | 2016 |
Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis.
Topics: Alkaloids; Biocatalysis; Chemistry Techniques, Synthetic; Ethanol; Kinetics; Piperidines | 2015 |
Lysine-derived Alkaloids: Overview and Update on Biosynthesis and Medicinal Applications with Emphasis on Quinolizidine Alkaloids.
Topics: Alkaloids; Indolizidines; Lycopodium; Lysine; Piperidines; Plants; Quinolizidines | 2017 |
Recent advancement of piperidine moiety in treatment of cancer- A review.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Humans; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Molecular Structure; Neoplasms; Piperidines; Structure-Activity Relationship | 2018 |
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents.
Topics: Animals; Antipsychotic Agents; Humans; Piperazine; Piperidines; Structure-Activity Relationship | 2021 |
Spirocyclic Nitroxides as Versatile Tools in Modern Natural Sciences: From Synthesis to Applications. Part I. Old and New Synthetic Approaches to Spirocyclic Nitroxyl Radicals.
Topics: Imidazoles; Imidazolidines; Morpholines; Natural Science Disciplines; Nitrogen Oxides; Oxazoles; Piperidines; Pyrrolidines; Reducing Agents | 2021 |
A Review of Chemistry and Pharmacology of Piperidine Alkaloids of Pinus and Related Genera.
Topics: Alkaloids; Pinus; Piperidines; Plant Extracts | 2022 |
Cyclisations and Strategies for Stereoselective Synthesis of Piperidine Iminosugars.
Topics: Alkenes; Azides; Cycloaddition Reaction; Piperidines | 2021 |
Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications.
Topics: Alkaloids; Cyclization; Piperidines; Stereoisomerism | 2023 |
Piperidine Nucleus as a Promising Scaffold for Alzheimer's Disease: Current Landscape and Future Perspective.
Topics: Alzheimer Disease; Humans; Neurodegenerative Diseases; Piperidines; Structure-Activity Relationship | 2023 |
740 other study(ies) available for piperidine and piperidines
| Article | Year |
|---|---|
Structure-activity relationship of minoxidil analogs as inhibitors of lysyl hydroxylase in cultured fibroblasts.
Topics: Antihypertensive Agents; Cells, Cultured; Fibroblasts; Humans; Infant; Male; Minoxidil; Piperidines; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Procollagen-Proline Dioxygenase; Pyrimidines; Skin; Structure-Activity Relationship | 1992 |
DNA strand cleavage at 8-hydroxyguanine residues by hot piperidine treatment.
Topics: Base Sequence; DNA; DNA Damage; Guanine; Hot Temperature; Molecular Sequence Data; Oligodeoxyribonucleotides; Piperidines; Spectrophotometry, Ultraviolet | 1992 |
Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines.
Topics: Allium; Anticarcinogenic Agents; Chromatography, Gas; Cystamine; Cysteamine; Cysteic Acid; Cysteine; Cystine; Diet; Garlic; Glutathione; Humans; Morpholines; Nitrosamines; Nitrosation; Piperidines; Plants, Medicinal; Pyrrolidines; Sulfhydryl Compounds; Thioglycolates | 1992 |
Slow, tight binding to human renin of some nonpeptidic renin inhibitors containing a 4-methoxymethoxypiperidinylamide at the P4 position.
Topics: Binding Sites; Enzyme Activation; Humans; Piperidines; Protein Binding; Renin; Structure-Activity Relationship | 1992 |
A new technique for determining the distribution of N7-methylguanine using an automated DNA sequencer.
Topics: Alkylation; DNA; DNA Damage; Escherichia coli; Gene Amplification; Guanine; Lac Operon; Molecular Sequence Data; Oligonucleotides; Piperidines; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sulfuric Acid Esters | 1991 |
Sequence analysis of end-labeled DNA fragments by solvolysis in aqueous solutions of different amines.
Topics: Amines; Base Sequence; Diethylamines; DNA; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Piperidines; Plasmids; Solutions | 1991 |
Osmium tetroxide reactivity of DNA bases in nucleotide sequencing and probing of DNA structure.
Topics: 2,2'-Dipyridyl; Base Sequence; DNA; DNA, Single-Stranded; Electrophoresis, Polyacrylamide Gel; Osmium Tetroxide; Piperidines; Poly A; Poly C; Poly G; Poly T; Spectrophotometry, Atomic; Thymine | 1991 |
Recognition and photo-induced cleavage and cross-linking of nucleic acids by oligonucleotides covalently linked to ellipticine.
Topics: Base Sequence; Cross-Linking Reagents; DNA; Ellipticines; Hydrogen-Ion Concentration; Macromolecular Substances; Molecular Sequence Data; Molecular Structure; Oligonucleotides; Photochemistry; Piperidines; Temperature; Ultraviolet Rays | 1991 |
Voltage clamp analysis of the kinetics of piperidine-induced chloride current in isolated Aplysia neurons.
Topics: Animals; Aplysia; Chloride Channels; Chlorides; In Vitro Techniques; Kinetics; Membrane Proteins; Neurons; Piperidines; Seawater | 1990 |
Differential sequence dynamics of homopolymeric and alternating AT tracts in a small plasmid DNA.
Topics: Base Sequence; DNA, Bacterial; DNA, Superhelical; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Formates; Molecular Sequence Data; Osmium Tetroxide; Piperidines; Plasmids; Promoter Regions, Genetic | 1991 |
Suppression of cyclobutane and mean value of 6-4 dipyrimidines formation in triple-stranded H-DNA.
Topics: Base Composition; Base Sequence; Cyclobutanes; DNA; Humans; Hydrolysis; Molecular Sequence Data; Nucleic Acid Conformation; Piperidines; Pyrimidine Dimers; Ultraviolet Rays | 1991 |
Reaction of single-stranded DNA with hydroxyl radical generated by iron(II)-ethylenediaminetetraacetic acid.
Topics: Base Sequence; Binding Sites; DNA; DNA Damage; DNA, Single-Stranded; Edetic Acid; Ferrous Compounds; Free Radicals; Hydrogen Peroxide; Molecular Sequence Data; Nucleotide Mapping; Oligodeoxyribonucleotides; Piperidines; Temperature | 1990 |
Sugar-shaped alkaloids.
Topics: Alkaloids; Heterocyclic Compounds; Indolizines; Piperidines; Pyrrolidines; Pyrrolizidine Alkaloids | 1990 |
Piperidine discriminates between the transient and the persistent components of the ACh-induced chloride current in Aplysia neurons.
Topics: Acetylcholine; Animals; Aplysia; Chlorides; In Vitro Techniques; Membrane Potentials; Neurons; Piperidines | 1990 |
Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA.
Topics: Base Sequence; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA Damage; DNA, Single-Stranded; Heme; Hemin; Molecular Sequence Data; Oligodeoxyribonucleotides; Piperidines | 1990 |
Oxidative DNA damage photo-induced by 3-carbethoxypsoralen and other furocoumarins. Mechanisms of photo-oxidation and recognition by repair enzymes.
Topics: Base Sequence; Deoxyribonuclease IV (Phage T4-Induced); DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Exodeoxyribonucleases; Furocoumarins; Light; Molecular Sequence Data; Oxidation-Reduction; Oxygen; Piperidines | 1989 |
Improved chemistry for oligodeoxyribonucleotide synthesis substantially improves restriction enzyme cleavage of a synthetic 35mer.
Topics: Adenine; Base Composition; Cloning, Molecular; DNA; DNA Modification Methylases; DNA Restriction Enzymes; Guanine; Oligodeoxyribonucleotides; Organophosphorus Compounds; Piperidines; Restriction Mapping; Substrate Specificity; Thymine | 1989 |
Rapid chemical mapping of dengue virus variability using RNA isolated directly from cells.
Topics: Base Composition; Base Sequence; Dengue Virus; DNA Probes; Hydroxylamine; Hydroxylamines; Molecular Sequence Data; Nucleic Acid Hybridization; Nucleotide Mapping; Osmium; Osmium Tetroxide; Piperidines; RNA, Viral | 1989 |
A simple high-resolution procedure to study DNA methylation and in vivo DNA-protein interactions on a single-copy gene level in higher eukaryotes.
Topics: 5-Methylcytosine; Animals; Chemical Phenomena; Chemistry; Chickens; Cytosine; DNA; DNA-Binding Proteins; Gene Amplification; Genes; Methylation; Piperidines; Promoter Regions, Genetic; Vitellogenins | 1989 |
Pyrrolidine, a non-controlled substance, can replace piperidine for the chemical sequencing of DNA.
Topics: Base Sequence; Chemical Phenomena; Chemistry; DNA; Piperidines; Pyrrolidines | 1989 |
Sequence analysis of end-labeled DNA fragments by solvolysis in hot aqueous piperidine solutions.
Topics: Autoradiography; Base Sequence; Chlorides; DNA; Hot Temperature; Hydrolysis; Lithium; Lithium Chloride; Piperidines; Sodium Chloride | 1988 |
A microiontophoretic study of the actions of the putative sleep factor, piperidine, in the rat brainstem.
Topics: Acetylcholine; Amino Acids; Animals; Brain Stem; Female; gamma-Aminobutyric Acid; Hexamethonium Compounds; In Vitro Techniques; Iontophoresis; Male; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Cholinergic; Sleep | 1985 |
Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentylenetetrazole; Pipecolic Acids; Piperidines; Seizures; Synaptic Transmission | 1985 |
Sites of gamma radiation-induced DNA strand breaks after alkali treatment.
Topics: Bacteriophage phi X 174; Base Sequence; Cobalt Radioisotopes; DNA, Viral; Dose-Response Relationship, Radiation; Gamma Rays; Phosphorus Radioisotopes; Piperidines | 1985 |
Chloroacetaldehyde reacts with Z-DNA.
Topics: Acetaldehyde; Base Sequence; DNA; Nucleotide Mapping; Piperidines | 1988 |
Evaluation of DNA binding characteristics of some CC-1065 analogs.
Topics: Animals; Antineoplastic Agents; Base Sequence; Cell Survival; Circular Dichroism; DNA; DNA Damage; DNA, Superhelical; Duocarmycins; In Vitro Techniques; Indoles; Leucomycins; Leukemia L1210; Mercaptoethanol; Piperidines; Stereoisomerism; Structure-Activity Relationship | 1988 |
Phosphodiester cleavage in apurinic dinucleotides.
Topics: Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; Guanine; Half-Life; Hydrochloric Acid; Hydrolysis; Kinetics; Oligodeoxyribonucleotides; Piperidines; Purines; Sodium Hydroxide; Thymine; Thymine Nucleotides | 1988 |
Complementary addressed modification of double-stranded DNA within a ternary complex.
Topics: Alkylation; Base Sequence; DNA; Hydrogen-Ion Concentration; Molecular Sequence Data; Mustard Compounds; Piperidines; Poly C; Polydeoxyribonucleotides | 1988 |
Piperidine: a microelectrophoretic study in the mammalian brain.
Topics: Acetylcholine; Action Potentials; Animals; Caudate Nucleus; Cerebral Cortex; Hippocampus; Male; Piperidines; Rats; Rats, Inbred Strains; Scopolamine; Tetraethylammonium Compounds | 1987 |
Adenine specific DNA chemical sequencing reaction.
Topics: Adenine; Base Sequence; Chromatography, High Pressure Liquid; DNA; DNA, Bacterial; Palladium; Piperidines; Plasmids | 1987 |
Cyclic amines are selective cytotoxic agents for pigmented cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Drug Synergism; Melanins; Melanoma; Mice; Morpholines; Pigmentation; Piperazine; Piperazines; Piperidines; Theophylline | 1986 |
Mechanism of DNA strand breakage by piperidine at sites of N7-alkylguanines.
Topics: Alkylation; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Piperidines | 1986 |
Effect of piperidine and related alicyclic amines on nicotinic and muscarinic agonist binding sites in the mammalian brain.
Topics: Amines; Animals; Animals, Newborn; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Mice; Nicotine; Parasympathomimetics; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Nicotinic; Species Specificity | 1986 |
One-lane sequence analysis of oligodeoxyribonucleotides.
Topics: Autoradiography; Base Sequence; DNA; Electrophoresis, Polyacrylamide Gel; Oligodeoxyribonucleotides; Piperidines; Polydeoxyribonucleotides | 1986 |
[Reactions of adenine and related compounds with formaldehyde].
Topics: Adenine; Benzyl Compounds; Chemical Phenomena; Chemistry; Formaldehyde; Kinetin; Magnetic Resonance Spectroscopy; Piperidines; Purines | 1985 |
Footprinting of DNA secondary structure by high-intensity (laser) ultraviolet irradiation.
Topics: Base Sequence; DNA; Endodeoxyribonucleases; Glycosides; Lasers; Nucleic Acid Conformation; Piperidines; Plasmids; Pyrimidine Dimers; Ultraviolet Rays | 1985 |
[Fluorescence of hemoproteins in reversed micelles of surfactants in octanes].
Topics: Animals; Colloids; Cytochrome b Group; Cytochrome c Group; Cytochromes b5; Dioctyl Sulfosuccinic Acid; Fluorescence; Horses; Micelles; Morpholines; Myoglobin; Octanes; Piperidines; Rabbits; Solutions; Surface-Active Agents; Whales | 1984 |
Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse.
Topics: Animals; Brain; Cadaverine; Carbon Radioisotopes; Diamines; Intestine, Large; Kidney; Kinetics; Liver; Lysine; Mice; Myocardium; Organ Specificity; Pipecolic Acids; Piperidines | 1983 |
Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid.
Topics: Animals; DNA, Superhelical; Drosophila melanogaster; Linoleic Acid; Linoleic Acids; Lipid Peroxides; Piperidines; Plasmids | 1984 |
Piperidine.
Topics: Air Pollutants, Occupational; Animals; Cats; Chemical Phenomena; Chemistry; Dogs; Guinea Pigs; Humans; Lethal Dose 50; Mice; Piperidines; Rabbits; Rats | 1982 |
Photooxidation of d(TpG) by riboflavin and methylene blue. Isolation and characterization of thymidylyl-(3',5')-2-amino-5-[(2-deoxy-beta-D- erythro-pentofuranosyl)amino]-4H-imidazol-4-one and its primary decomposition product thymidylyl-(3',5')-2,2-diamin
Topics: Bacteriophage T4; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnetic Resonance Spectroscopy; Methoxamine; Methylene Blue; Oxazoles; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorylation; Photochemistry; Piperidines; Polynucleotide 5'-Hydroxyl-Kinase; Riboflavin; Spectrometry, Mass, Fast Atom Bombardment; Thymidine | 1995 |
Nitrosatable amines and nitrosamide formation in natural stimulants: Cola acuminata, C. nitida and Garcinia cola.
Topics: Amines; Central Nervous System Stimulants; Chromatography, Gas; Methylation; Nigeria; Nitrosation; Nitroso Compounds; Piperidines; Plant Extracts; Plants, Medicinal; Pyrrolidines; Seeds | 1995 |
Coumarin derivatives enhance the chemiluminescence accompanying lipid peroxidation.
Topics: Coloring Agents; Coumarins; Free Radicals; Iron; Kinetics; Lasers; Lipid Metabolism; Liposomes; Luminescent Measurements; Piperidines; Pyrrolidines | 1995 |
A new interference footprinting method for analysing simultaneously protein contacts to phosphate and guanine residues on DNA.
Topics: Base Sequence; DNA; DNA-Binding Proteins; Ethylnitrosourea; Genetic Techniques; Guanine; Molecular Sequence Data; NF-kappa B; Phosphates; Piperidines; Sequence Analysis, DNA; Sodium Hydroxide | 1995 |
Mitomycin C-induced distortions of DNA at minor alkylation sites.
Topics: Alkylation; Base Sequence; Binding Sites; Cytosine; Deoxyribonuclease HindIII; DNA; DNA-Directed DNA Polymerase; Exodeoxyribonuclease V; Exodeoxyribonucleases; Hydroxylamine; Hydroxylamines; Mitomycin; Molecular Sequence Data; Piperidines; Viral Proteins | 1995 |
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
Topics: Amsacrine; Azides; Base Sequence; Binding Sites; Cell-Free System; DNA Damage; DNA Topoisomerases, Type II; In Vitro Techniques; Molecular Sequence Data; Oligodeoxyribonucleotides; Photochemistry; Piperidines | 1994 |
One-lane chemical sequencing of 3'-fluorescent-labeled DNA.
Topics: Autoanalysis; Base Sequence; Computer Systems; Densitometry; DNA; Fluorescence; Formamides; Lasers; Molecular Sequence Data; Piperidines; Point Mutation | 1993 |
DNA sequencing by the chemical method.
Topics: Acetates; Acetic Acid; Cacodylic Acid; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Hydrazines; Piperidines; Sequence Analysis, DNA; Sulfuric Acid Esters | 1993 |
Monofunctional adducts of platinum(II) produce in DNA a sequence-dependent local denaturation.
Topics: Acetaldehyde; Base Composition; Base Sequence; Chromosome Mapping; Cisplatin; Deoxyribonucleases, Type II Site-Specific; DNA; Enzyme-Linked Immunosorbent Assay; Hydrogen Bonding; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Piperidines; Spectrometry, Fluorescence; Transcription, Genetic | 1994 |
DNA conformation-induced activation of an enediyne for site-specific cleavage.
Topics: Base Sequence; Biotransformation; DNA Damage; DNA, Single-Stranded; Enediynes; Molecular Sequence Data; Nucleic Acid Conformation; Oxidation-Reduction; Piperidines; Point Mutation; Sulfhydryl Compounds; Zinostatin | 1993 |
Single-step piperidine elution, cleavage, and recovery of premodified DNA electrotransferred on NA-45 membrane from mobility-shift gels.
Topics: DEAE-Cellulose; DNA; Electrophoresis, Polyacrylamide Gel; Genetic Techniques; Membranes, Artificial; Piperidines | 1993 |
Chemical cleavage of mismatch to detect mutations.
Topics: Autoradiography; Base Composition; DNA; DNA Probes; DNA, Recombinant; Electrophoresis, Polyacrylamide Gel; Hydroxylamine; Hydroxylamines; Indicators and Reagents; Mutagenesis; Mutation; Osmium Tetroxide; Phosphorus Radioisotopes; Piperidines; Polymerase Chain Reaction; Sulfur Radioisotopes | 1993 |
Preparation and characterization of a set of deoxyoligonucleotide 49-mers containing site-specific cis-syn, trans-syn-I, (6-4), and Dewar photoproducts of thymidylyl(3'-->5')-thymidine.
Topics: Base Sequence; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; DNA Damage; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligodeoxyribonucleotides; Photolysis; Piperidines | 1993 |
Beta subunit coexpression and the alpha1 subunit domain I-II linker affect piperidine block of neuronal calcium channels.
Topics: Animals; Calcium Channels; Dose-Response Relationship, Drug; Membrane Potentials; Molecular Structure; Neurons; Oocytes; Patch-Clamp Techniques; Phenyl Ethers; Piperidines; Procaine; Xenopus | 1996 |
Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation.
Topics: Acetates; Alkylation; Binding Sites; DNA; DNA Restriction Enzymes; Electrophoresis, Polyacrylamide Gel; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Piperidines; Plasmids; Purines; Pyrimidines | 1996 |
Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides.
Topics: Base Sequence; Hydrogen-Ion Concentration; Indicators and Reagents; Molecular Structure; Oligodeoxyribonucleotides; Pentoses; Piperidines | 1995 |
Single-tube chemical cleavage of mismatch: successive treatment with hydroxylamine and osmium tetroxide.
Topics: Base Composition; Chemistry Techniques, Analytical; Cytosine; Electrophoresis, Polyacrylamide Gel; Globins; Hydrolysis; Hydroxylamine; Hydroxylamines; Nucleic Acid Hybridization; Osmium Tetroxide; Piperidines; Sequence Homology, Nucleic Acid; Thymidine | 1996 |
Design of protecting groups for the beta-carboxylic group of aspartic acid that minimize base-catalyzed aspartimide formation.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Esters; Oligopeptides; Piperidines; Temperature; Time Factors | 1996 |
Genomic footprinting of mitochondrial DNA: I. In organello analysis of protein-mitochondrial DNA interactions in bovine mitochondria.
Topics: Animals; Base Sequence; Cattle; Cloning, Molecular; DNA Footprinting; DNA Probes; DNA-Binding Proteins; DNA, Mitochondrial; Genome; Indicators and Reagents; Methylation; Mitochondria; Molecular Sequence Data; Piperidines; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Sulfuric Acid Esters | 1996 |
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.
Topics: Amino Acids; Cross-Linking Reagents; Imines; Leucine; Models, Chemical; Organophosphorus Compounds; Oxazoles; Phosphorus; Piperidines; Proline; Sulfhydryl Compounds; Thioamides | 1996 |
Improvements in automated PNA synthesis using Boc/Z monomers.
Topics: Biopolymers; Chromatography, High Pressure Liquid; Glycine; Nucleic Acids; Peptides; Piperidines; Purines; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1997 |
Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid.
Topics: Alanine; Alkylation; Animals; Aspartic Acid; Benzamides; Benzamidines; Benzoates; Benzoic Acid; beta-Alanine; Carbamates; Esterases; Humans; Liver; Magnetic Resonance Spectroscopy; Oligopeptides; Piperazine; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Structure-Activity Relationship; Sulfonamides; Swine | 1997 |
Degradation of morpholine by an environmental Mycobacterium strain involves a cytochrome P-450.
Topics: Acetates; Biodegradation, Environmental; Carbon Monoxide; Cytochrome P-450 Enzyme System; Ethanolamine; Ethylamines; Glycolates; Hydrogen; Industrial Waste; Magnetic Resonance Spectroscopy; Metyrapone; Morpholines; Mycobacterium; Piperidines; Pyrrolidines; Sewage; Succinic Acid | 1998 |
Investigation on the stability of the Dde protecting group used in peptide synthesis: migration to an unprotected lysine.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Dimethylformamide; Drug Stability; Fluorenes; Lysine; Mass Spectrometry; Molecular Structure; Peptides; Piperidines | 1998 |
Solid-phase synthesis and on-resin cyclization of a disulfide bond peptide and lactam analogues corresponding to the major antigenic site of HIV gp41 protein.
Topics: Antibodies, Monoclonal; Biochemistry; Biotin; Dimethylformamide; Disulfides; Enzyme-Linked Immunosorbent Assay; Epitopes; HIV Envelope Protein gp41; HIV Infections; Humans; Lactams; Peptides; Piperidines | 1998 |
Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Bronchoconstriction; Capillary Permeability; Dibenzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Delayed; Imidazoles; Ketotifen; Leukocytes; Male; Mice; Mice, Inbred ICR; Nasal Mucosa; Passive Cutaneous Anaphylaxis; Piperidines; Rats; Rats, Wistar; Respiratory Hypersensitivity | 1998 |
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Capillary Permeability; Dibenzazepines; Dinoprostone; Dose-Response Relationship, Drug; Free Radical Scavengers; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Ileum; Imidazoles; In Vitro Techniques; Intramolecular Oxidoreductases; Ketotifen; Leukotriene B4; Leukotriene C4; Lipocalins; Lung; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Piperidines; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Respiratory Hypersensitivity; Serotonin; Sheep; Skin Physiological Phenomena; Trachea | 1998 |
Cytoplasmic determinants of piperidine blocking affinity for N-type calcium channels.
Topics: Binding Sites; Biological Transport; Calcium Channel Blockers; Calcium Channels; Cell Line; GTP-Binding Proteins; Humans; Kidney; Piperidines | 1999 |
Synthesis and enzymatic processing of oligodeoxynucleotides containing tandem base damage.
Topics: Alkaline Phosphatase; Animals; Base Pairing; Cattle; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli Proteins; Exonucleases; Guanine; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; Piperidines; Single-Strand Specific DNA and RNA Endonucleases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1999 |
Anomalous cross-linking by mechlorethamine of DNA duplexes containing C-C mismatch pairs.
Topics: Alkylating Agents; Alkylation; Base Pair Mismatch; Bisbenzimidazole; Cross-Linking Reagents; DNA; Guanine; Hydrogen-Ion Concentration; Mechlorethamine; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Piperidines; Sulfuric Acid Esters | 1999 |
Oxidative DNA damage by a metabolite of carcinogenic and reproductive toxic nitrobenzene in the presence of NADH and Cu(II).
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Catalase; Cations; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Copper; Cytosine; Deoxyguanosine; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Guanine; Humans; Hydrogen Peroxide; Metals; Models, Chemical; NAD; Nitrobenzenes; Nitroso Compounds; Oxidation-Reduction; Piperidines; Thymine | 1999 |
Analysis of 8-hydroxyguanine in rat kidney genomic DNA after administration of a renal carcinogen, ferric nitrilotriacetate.
Topics: Animals; Base Sequence; Carcinogens; DNA; DNA Damage; Ferric Compounds; Guanine; HSP70 Heat-Shock Proteins; Kidney; Male; Molecular Sequence Data; Nitrilotriacetic Acid; Piperidines; Protozoan Proteins; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Tumor Suppressor Protein p53 | 1999 |
Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety.
Topics: Blood Coagulation Factors; Carboxylic Acids; Factor Xa Inhibitors; Inhibitory Concentration 50; Kinetics; Models, Chemical; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazoles; Thrombin | 1999 |
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.
Topics: Animals; CHO Cells; Clozapine; Cricetinae; Humans; Kinetics; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4; Serotonin Antagonists | 1999 |
Cloning and characterization of the genes encoding a cytochrome P450 (PipA) involved in piperidine and pyrrolidine utilization and its regulatory protein (PipR) in Mycobacterium smegmatis mc2155.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Blotting, Southern; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Transposable Elements; DNA-Binding Proteins; Escherichia coli Proteins; Genes, Bacterial; Glucose; Kinetics; Molecular Sequence Data; Mutagenesis, Insertional; Mycobacterium smegmatis; Open Reading Frames; Piperidines; Pyrrolidines; Repressor Proteins; Sequence Analysis, DNA; Sequence Homology; Transcription Factors | 1999 |
Degradation of morpholine, piperidine, and pyrrolidine by mycobacteria: evidences for the involvement of a cytochrome P450.
Topics: Base Sequence; Biodegradation, Environmental; Cytochrome P-450 Enzyme System; Enzyme Induction; Molecular Sequence Data; Morpholines; Mycobacterium; Phylogeny; Piperidines; Pyrrolidines; RNA, Bacterial; RNA, Ribosomal, 16S; Soil Microbiology | 1999 |
Synthesis and biochemical properties of cyanuric acid nucleoside-containing DNA oligomers.
Topics: Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Polymerase I; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli Proteins; Guanine; Mass Spectrometry; N-Glycosyl Hydrolases; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Nucleosides; Oligodeoxyribonucleotides; Piperidines; Triazines | 1999 |
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.
Topics: Antihypertensive Agents; Inhibitory Concentration 50; Molecular Structure; Piperidines; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Receptors, Purinergic P1; Solubility; Structure-Activity Relationship; Water; Xanthines | 1999 |
Oxidiazole synthesis on solid supports.
Topics: Chemistry, Organic; Chromatography, High Pressure Liquid; Oxadiazoles; Piperidines; Solvents; Temperature | 1999 |
Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.
Topics: Animals; Anti-Allergic Agents; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Guinea Pigs; Histamine Antagonists; Humans; Inhibitory Concentration 50; Isoquinolines; Loratadine; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rats; Receptors, Histamine H1; Stereoisomerism; Structure-Activity Relationship | 1999 |
The reactivity of the 2-deoxyribonolactone lesion in single-stranded DNA and its implication in reaction mechanisms of DNA damage and repair.
Topics: Ammonia; DNA Adducts; DNA Damage; DNA Repair; DNA, Single-Stranded; Ethylenediamines; Mercaptoethanol; Oligodeoxyribonucleotides; Piperidines; Sugar Acids; Water | 1999 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Biological Availability; Blood Pressure; Dogs; Drug Design; Drug Evaluation, Preclinical; GTP-Binding Proteins; Half-Life; Humans; In Vitro Techniques; Male; Microsomes; Piperidines; Prostate; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Opioid, mu; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Urethra | 1999 |
Molecular complexes of iron violurate with donor amines.
Topics: Amines; Anti-Infective Agents; Antifungal Agents; Barbiturates; Diethylamines; Drug Evaluation, Preclinical; Ethylamines; Piperidines; Solvents; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics; Vibration | 1999 |
Venom alkaloids of fire ants in relation to worker size and age.
Topics: Age Factors; Alkaloids; Animals; Ant Venoms; Ants; Piperidines | 2000 |
Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues.
Topics: Animals; Bacterial Proteins; Base Pair Mismatch; Base Sequence; DNA; DNA Glycosylases; Escherichia coli; Fungal Proteins; Humans; Hypoxanthine; Inosine Monophosphate; Kinetics; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Piperidines; Rats; Saccharomyces cerevisiae; Substrate Specificity; Thermodynamics | 2000 |
Copper-dependent DNA damage induced by hydrazobenzene, an azobenzene metabolite.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Azo Compounds; Catalase; Cattle; Chelating Agents; Copper; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Oxidation-Reduction; Phenanthrolines; Phenylhydrazines; Piperidines | 2000 |
EPR spin trapping detection of carbon-centered carotenoid and beta-ionone radicals.
Topics: Anions; beta Carotene; Canthaxanthin; Carotenoids; Cations; Electrochemistry; Electron Spin Resonance Spectroscopy; Free Radicals; Norisoprenoids; Piperidines; Protons; Spin Labels; Terpenes | 2000 |
High morpholine degradation rates and formation of cytochrome P450 during growth on different cyclic amines by newly isolated Mycobacterium sp. strain HE5.
Topics: Amines; Biodegradation, Environmental; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanolamine; Glycolates; Glyoxylates; Hydrogen-Ion Concentration; Metyrapone; Molecular Sequence Data; Morpholines; Nontuberculous Mycobacteria; Piperidines; Pyrrolidines; Soil Microbiology; Spectrophotometry, Ultraviolet; Substrate Specificity; Succinic Acid; Temperature; Time Factors | 2000 |
The DNA damage spectrum produced by simulated sunlight.
Topics: Alkalies; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Mutational Analysis; Dose-Response Relationship, Radiation; Endodeoxyribonucleases; Fibroblasts; Genes, p53; Hot Temperature; Humans; Mutagenesis; Neurospora crassa; Oligodeoxyribonucleotides; Piperidines; Plasmids; Pyrimidine Dimers; Reproducibility of Results; Time Factors; Ultraviolet Rays | 2000 |
Repair and coding properties of 5-hydroxy-5-methylhydantoin nucleosides inserted into DNA oligomers.
Topics: Deoxyribonucleases; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Oligonucleotides; Organophosphorus Compounds; Piperidines | 2000 |
Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme.
Topics: Chromatography, High Pressure Liquid; DNA; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Guanine; N-Glycosyl Hydrolases; Nitrates; Oligonucleotides; Oxidants; Oxidation-Reduction; Piperidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2000 |
DNA degradation by the mixture of copper and catechol is caused by DNA-copper-hydroperoxo complexes, probably DNA-Cu(I)OOH.
Topics: Catechols; Copper; DNA; DNA Damage; Free Radical Scavengers; Guanine; Hydroxyl Radical; Osmolar Concentration; Piperidines; Reactive Oxygen Species | 2000 |
Improved in vivo dimethyl sulfate footprinting using AlkA protein: DNA-protein interactions at the mouse H19 gene promoter in primary embryo fibroblasts.
Topics: Alkylating Agents; Animals; Base Sequence; Deoxyribonuclease I; DNA; DNA Footprinting; DNA Glycosylases; Embryo, Mammalian; Fibroblasts; Genetic Techniques; Mice; Molecular Sequence Data; N-Glycosyl Hydrolases; Piperidines; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Binding; RNA, Long Noncoding; RNA, Untranslated; Sulfuric Acid Esters; Ultraviolet Rays | 2000 |
Electrospray ionization/mass spectrometry compatible reversed-phase separation of phospholipids: piperidine as a post column modifier for negative ion detection.
Topics: Animals; Anions; Bacteria; Brain Chemistry; Chromatography, High Pressure Liquid; Egg Yolk; Mass Spectrometry; Phospholipids; Piperidines | 2000 |
Expression and conditioned inhibition of fear-potentiated startle after stimulation and blockade of AMPA/Kainate and GABA(A) receptors in the dorsal periaqueductal gray.
Topics: Acoustic Stimulation; Animals; Conditioning, Classical; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fear; Kainic Acid; Light; Male; Microinjections; Periaqueductal Gray; Picrotoxin; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reflex, Startle | 2000 |
Mechanisms of DNA cleavage by copper complexes of 3-clip-phen and of its conjugate with a distamycin analogue.
Topics: Animals; Bleomycin; Cattle; Chromatography, High Pressure Liquid; Copper; Distamycins; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Furaldehyde; Gas Chromatography-Mass Spectrometry; Glycolates; Iron; Malondialdehyde; Oxidants; Oxidation-Reduction; Phenanthrolines; Piperidines; Substrate Specificity; Zinostatin | 2000 |
New strong fibrates with piperidine moiety.
Topics: Animals; Disease Models, Animal; Hypercholesterolemia; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Piperazine; Piperazines; Piperidines; Propionates; Rats; Rats, Sprague-Dawley | 2000 |
Separation and determination of haloperidol, parabens and some of their degradation products by micellar electrokinetic chromatography.
Topics: Benzoates; Calibration; Chromatography, Micellar Electrokinetic Capillary; Haloperidol; Parabens; Piperidines | 2000 |
Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines.
Topics: Alkylating Agents; Alkylation; Base Sequence; Cell Line, Transformed; Chromatin; Dimethyl Sulfoxide; DNA; DNA Damage; DNA Footprinting; DNA Methylation; Exons; Fragile X Mental Retardation Protein; Guanine; Humans; Lymphocytes; Molecular Conformation; Molecular Sequence Data; Nerve Tissue Proteins; Piperidines; Potassium Permanganate; Promoter Regions, Genetic; Purines; RNA-Binding Proteins; Sulfones; Sulfuric Acid Esters | 2001 |
Studies of the operator region of the Staphylococcus aureus beta-lactamase operon.
Topics: Bacterial Proteins; Base Sequence; beta-Lactamases; Chloramphenicol O-Acetyltransferase; Deoxyribonuclease I; DNA; DNA Footprinting; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Bacterial; Genes, Reporter; Molecular Sequence Data; Nucleic Acid Conformation; Operator Regions, Genetic; Phenanthrolines; Piperidines; Plasmids; Promoter Regions, Genetic; Repressor Proteins; Sequence Deletion; Staphylococcus aureus; Sulfuric Acid Esters; Time Factors | 2001 |
Charge transport through DNA four-way junctions.
Topics: 2,2'-Dipyridyl; Base Pairing; Base Sequence; Cations, Divalent; Crossing Over, Genetic; DNA; DNA Damage; Electron Transport; Guanine; Intercalating Agents; Magnesium; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Organometallic Compounds; Oxidants; Photolysis; Piperidines; Rhodium | 2001 |
A short synthesis of argatroban. a potent selective thrombin inhibitor.
Topics: Antithrombins; Arginine; Enzyme Inhibitors; Pipecolic Acids; Piperidines; Sensitivity and Specificity; Sulfonamides | 2001 |
Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.
Topics: Binding Sites; Calcium; Cells, Cultured; Ghrelin; Humans; Indoles; Inhibitory Concentration 50; Luminescence; Molecular Mimicry; Peptide Hormones; Peptides; Piperidines; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Spiro Compounds | 2001 |
Ntg2 of Saccharomyces cerevisiae repairs the oxidation products of 8-hydroxyguanine.
Topics: Borohydrides; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Formamidopyrimidine Glycosylase; Dose-Response Relationship, Radiation; Escherichia coli Proteins; Gamma Rays; Guanine; Hydrogen Peroxide; Hydroxyl Radical; Iron; Macromolecular Substances; N-Glycosyl Hydrolases; Oxidation-Reduction; Piperidines; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity; Thymidine | 2001 |
Chemical cross-linking of drugs to DNA.
Topics: Binding Sites; Cross-Linking Reagents; Deoxyguanosine; DNA; DNA Adducts; Doxorubicin; Electrophoresis, Polyacrylamide Gel; Ethidium; Gas Chromatography-Mass Spectrometry; Hydrolysis; In Vitro Techniques; Nucleic Acid Denaturation; Pharmaceutical Preparations; Piperidines; Spectrometry, Fluorescence | 2001 |
Optimal conditions to use Pfu exo(-) DNA polymerase for highly efficient ligation-mediated polymerase chain reaction protocols.
Topics: Base Sequence; Chromosome Breakage; DNA; DNA Damage; DNA Ligases; DNA Primers; DNA-Directed DNA Polymerase; GC Rich Sequence; Genome, Human; Humans; Lymphocytes; Male; Nucleic Acid Conformation; Nucleic Acid Denaturation; Osmolar Concentration; Physical Chromosome Mapping; Piperidines; Polymerase Chain Reaction; Pyrococcus furiosus; Salts; Taq Polymerase; Temperature; Thermodynamics | 2001 |
Modification of Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and their relation to the inhibition of sodium channels.
Topics: Amino Acid Sequence; Animals; Arginine; Circular Dichroism; Conotoxins; Male; Molecular Sequence Data; Muscle Contraction; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers | 2001 |
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.
Topics: Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oxadiazoles; Piperidines; Structure-Activity Relationship | 2001 |
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.
Topics: Animals; Anti-HIV Agents; Butanes; CCR5 Receptor Antagonists; Cells, Cultured; Chemokine CCL4; Cricetinae; Humans; Inhibitory Concentration 50; Macrophage Inflammatory Proteins; Models, Biological; Models, Molecular; Neutrophils; Piperidines; Structure-Activity Relationship | 2001 |
Efficient enantiomeric synthesis of pyrrolidine and piperidine alkaloids from tobacco.
Topics: Alkaloids; Magnetic Resonance Spectroscopy; Molecular Conformation; Nicotiana; Piperidines; Plants, Toxic; Pyrrolidines | 2001 |
Repair of triplex-directed DNA alkylation by nucleotide excision repair.
Topics: Alkylation; DNA; DNA Adducts; DNA Damage; DNA Ligases; DNA Repair; Genes, erbB-2; Guanidine; HeLa Cells; Humans; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Piperidines; Polymerase Chain Reaction; Promoter Regions, Genetic; Substrate Specificity; Transfection | 2001 |
Synthesis of DTPA analogues derived from piperidine and azepane: potential contrast enhancement agents for magnetic resonance imaging.
Topics: Contrast Media; Gadolinium; Gadolinium DTPA; Heterocyclic Compounds; Magnetic Resonance Imaging; Nuclear Magnetic Resonance, Biomolecular; Pentetic Acid; Piperidines; Radioisotopes | 2001 |
Piperidine as an efficient organic catalyst of derivatization of oligosaccharides with malononitrile for high-sensitivity electrospray ionization mass analysis.
Topics: Catalysis; Ions; Models, Chemical; Nitriles; Oligosaccharides; Piperidines; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2001 |
Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Benzopyrenes; Binding Sites; Carcinogens; Cattle; Copper; Cyclin-Dependent Kinase Inhibitor p16; Deoxyguanosine; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Free Radical Scavengers; Genes, p53; Genes, ras; Humans; N-Glycosyl Hydrolases; NAD; Oxidation-Reduction; Piperidines | 2002 |
Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for mu opioid and I2-imidazoline receptors: synthesis and pharmacological screening.
Topics: Amides; Analgesics; Animals; Drug Evaluation, Preclinical; Guanidine; Guinea Pigs; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ligands; Male; Mice; Piperidines; Radioligand Assay; Receptors, Drug; Receptors, Opioid, mu; Sensation; Structure-Activity Relationship | 2002 |
DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bromates; Carcinogens; Cattle; Cell Line; Deoxyguanosine; Dimethyl Sulfoxide; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Glutathione; Humans; Inflammation; Neoplasms; Oxidation-Reduction; Phosphorus Isotopes; Piperidines; Sodium Hypochlorite | 2002 |
DNA modification by 4-aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity.
Topics: Alkynes; Antineoplastic Agents; Aza Compounds; Benzimidazoles; Benzothiazoles; Cytosine; DNA Adducts; DNA, Superhelical; Growth Inhibitors; Heterocyclic Compounds, 2-Ring; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hydrolysis; Piperidines; Thiazoles; Tumor Cells, Cultured; U937 Cells | 2002 |
Piperidine alkaloids in sitka spruce with varying levels of resistance to white pine weevil (Coleoptera: Curculionidae).
Topics: Alkaloids; Animals; Coleoptera; Pest Control, Biological; Picea; Piperidines | 2002 |
Stereochemical control of Zn(II)/Cu(II) selectivity in piperidine tripod ligands.
Topics: Copper; Ligands; Molecular Conformation; Nanotechnology; Piperidines; Sensitivity and Specificity; Spectrometry, Fluorescence; Zinc | 2002 |
Anaerobic degradation of pyrrolidine and piperidine coupled with nitrate reduction.
Topics: Bacteria, Anaerobic; Biodegradation, Environmental; Calcium Channel Blockers; Environmental Pollutants; Gases; Nitrates; Oxidation-Reduction; Piperidines; Pyrrolidines | 2002 |
Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine.
Topics: Animals; Cadaverine; Cell Migration Inhibition; Cell Polarity; Cells, Cultured; Chemotaxis, Leukocyte; Epithelial Cells; Humans; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Neutrophils; Phosphorylation; Piperidines; Protein Kinase C; Salmonella typhimurium | 2002 |
Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors.
Topics: Amines; Heterocyclic Compounds; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Morpholines; Nitrogen Isotopes; Piperazine; Piperazines; Piperidines; Solvents | 2002 |
Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins.
Topics: Amines; Animals; Binding Sites; Horses; Hydrogen Bonding; Isomerism; Ligands; Methionine; Myoglobin; Organoplatinum Compounds; Picolines; Piperazine; Piperazines; Piperidines; Protein Binding; Protein Folding; Spectrometry, Mass, Electrospray Ionization; Static Electricity; Ubiquitin | 2003 |
Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Electron Transport; Humans; Hydrolysis; Methotrexate; Molecular Structure; Phosphorus Radioisotopes; Photolysis; Piperidines; Poly G; Pteridines; Spectrometry, Fluorescence | 2002 |
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Topics: Animals; Anti-HIV Agents; CCR5 Receptor Antagonists; Dogs; Half-Life; Humans; Leukocytes, Mononuclear; Macaca mulatta; Metabolic Clearance Rate; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Detection of mutations in DNA by solid-phase chemical cleavage method. A simplified assay.
Topics: Base Pair Mismatch; DNA; DNA Mutational Analysis; Electrophoresis; Hydroxylamine; Piperidines; Potassium Permanganate; Silicon Dioxide | 2003 |
[Determination of elemenyl piperidine salt in water by capillary gas chromatography].
Topics: Antineoplastic Agents, Phytogenic; Chromatography, Gas; Piperidines; Plant Extracts; Sesquiterpenes; Water | 2000 |
Stereoselective solid-phase synthesis of chiral piperidine derivatives by using an immobilized galactose auxiliary.
Topics: Galactosamine; Galactose; Molecular Structure; Piperidines; Polymers; Stereoisomerism | 2003 |
Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Histamine Antagonists; Imidazoles; In Vitro Techniques; Male; Mice; Piperidines; Protein Binding; Receptors, Histamine H3 | 2003 |
Radiation-activated nuclease activity of o,o'-Diphenyleneiodonium cations (DPI): a reductively initiated chain reaction involving the C1' chemistry.
Topics: Animals; Cations; Cattle; Cobalt Radioisotopes; DNA; DNA Damage; Electrons; Enzyme Inhibitors; Furans; Gamma Rays; Kinetics; Models, Chemical; Onium Compounds; Piperidines | 2003 |
Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Binding Sites; Brain; Drug Interactions; gamma-Aminobutyric Acid; Isomerism; Molecular Structure; Muscimol; Piperidines; Rabbits; Receptors, GABA-A; Receptors, GABA-B; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes; Synaptosomes; Taurine; Tritium | 2003 |
Biodegradation of cyclic amines by a Pseudomonas strain involves an amine mono-oxygenase.
Topics: Amines; Biodegradation, Environmental; Cell Extracts; Culture Media; Cytochrome P-450 Enzyme System; gamma-Aminobutyric Acid; Mixed Function Oxygenases; Models, Molecular; Piperidines; Potassium Cyanide; Pseudomonas putida; Pyrrolidines; Soil Microbiology; Spectrophotometry | 2003 |
A metal-centered hydrophobic pocket recognizing pyridine over piperidine.
Topics: Copper; Cyclohexylamines; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Organometallic Compounds; Picolines; Piperidines; Platinum; Pyridines | 2003 |
The aspartimide problem in Fmoc-based SPPS. Part II.
Topics: Amino Acids; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Fluorenes; Peptide Biosynthesis; Peptides; Piperidines | 2003 |
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action.
Topics: Animals; Antineoplastic Agents; Base Sequence; CHO Cells; Cisplatin; Cricetinae; Cross-Linking Reagents; DNA; DNA Adducts; DNA Polymerase I; Dose-Response Relationship, Drug; HeLa Cells; HIV Reverse Transcriptase; Humans; Hydroxyl Radical; Ligands; Models, Chemical; Models, Theoretical; Molecular Sequence Data; Oligonucleotides; Piperidines; Platinum; Time Factors | 2003 |
[Convulsive action of nucleus of keto-piperidine in the molecule of strychnine].
Topics: Cell Nucleus; Piperidines; Strychnine | 1952 |
[Convulsive action of the keto-piperidine nucleus in the strychinine molecule].
Topics: Cell Nucleus; Piperidines; Seizures; Strychnine | 1952 |
[Synthesis of spasmolytic alkanolamine esters of alpha-phenyl-alpha-piperidine acetic acid].
Topics: Acetates; Esters; Parasympatholytics; Piperidines | 1953 |
[Synthesis of new hypnotics from pyridine and piperidine groups].
Topics: Hypnotics and Sedatives; Piperidines; Pyridines | 1954 |
[Derivatives of N-(2-aminoethyl)-piperidine of pharmacological interest. IV..].
Topics: Piperidines | 1954 |
[Methoxy- and methylenedihydroxy-derivatives of 1-(2-arylaminoethyl)-piperidine and 1-(2-aralkylaminoethyl)-piperidine of pharmacological interest. V..].
Topics: Humans; Piperidines | 1954 |
[Partially hydrogenated N-aryl- and N-aralkyl-derivatives of 1-(2-aminoethyl)-piperidine. VI..].
Topics: Hydrogenation; Piperidines | 1954 |
[Analeptic effect of a new piperidine derivative].
Topics: Anti-Allergic Agents; Central Nervous System Stimulants; Humans; Piperidines | 1954 |
The comparative anticholinergic activity of a series of derivatives of 3-hydroxy piperidine.
Topics: Cholinergic Antagonists; Parasympatholytics; Piperidines | 1954 |
[Rapid evaluation of the toxicity of a series of compounds; toxicity of some derivatives of N-(2-aminoethyl)-piperidine].
Topics: Piperidines | 1954 |
[Experiences with a new piperidine hypnotic in psychiatry].
Topics: Hypnotics and Sedatives; Mental Disorders; Piperidines; Psychiatry; Psychotherapy | 1955 |
[Clinical trial of a new piperidine compound as soporific].
Topics: Chlorpromazine; Humans; Piperidines; Sleep Wake Disorders | 1955 |
[(2-Diphenylmethyl-piperidine hydrochloride and the methyl ester of 2-chloro-2-phenyl-2-(2-piperidyl)-acetic acid), drugs with waking effect in anesthesia].
Topics: Acetates; Anesthesia; Anesthesiology; Piperidines | 1955 |
Studies on cholinergic blocking substances. VIII. Pharmacological actions of certain polymethylene-, bis- and azapentylene-bis-pyrrolidine and piperidine derivatives.
Topics: Autonomic Agents; Cholinergic Agents; Humans; Piperidines; Pyrrolidines | 1955 |
Plant enzyme reactions leading to the formation of heterocyclic compounds. 1. The formation of unsaturated pyrrolidine and piperidine compounds.
Topics: Oxidoreductases; Piperidines; Plants; Pyrroles; Pyrrolidines | 1955 |
[Pharmacologic properties of new synthetic curare simulants; sulfonium analogue of methonium salts, derivatives of pyridine carbonic and piperidine carbonic acids].
Topics: Carbon; Carbonic Acid; Curare; Muscle Relaxants, Central; Piperidines; Pyridines; Salts | 1955 |
[Clinical observations on a new piperidine derivative of hypnotic sedative action].
Topics: Anti-Allergic Agents; Hypnotics and Sedatives; Piperidines | 1955 |
[Anthelmintic action of fatty acid salts of ethylenediamines, diethylenediamine, piperidine and morpholine].
Topics: Anthelmintics; Ethylenediamines; Fatty Acids; Morpholines; Piperazines; Piperidines; Salts | 1955 |
[Clinical proof of a new soporific of the piperidine series].
Topics: Hypnotics and Sedatives; Piperidines | 1956 |
[Behavior of basal metabolism after pre-anesthesia medication with derivatives of dibenzoparathiazine and piperidine].
Topics: Anesthesia; Basal Metabolism; Hibernation; Humans; Meperidine; Piperidines | 1955 |
[Studies on sulfur. I. Determination of elementary sulfur by piperidine].
Topics: Fibrinogen; Piperidines; Sulfur | 1956 |
Clinical trial of methyprylone, a piperidine hypnotic.
Topics: Barbiturates; Humans; Hypnotics and Sedatives; Piperidines; Piperidones | 1956 |
[New compounds with amine and amide function derived from hydrogenated quinolines containing piperidine and morpholine radicals].
Topics: Amides; Amines; Morpholines; Piperidines; Quinolines | 1956 |
[A drug with tetanizing effect on frogs; secondary piperidine methylene-disalicylate].
Topics: Animals; Anura; Humans; Methane; Piperidines | 1957 |
[Interference in the development of experimental arteriosclerosis due to adrenalin in rabbits pretreated with 1-methyl-4-(m-hydroxyphenyl)-4-propionyl-piperidine].
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Arteriosclerosis; Epinephrine; Piperidines; Rabbits | 1957 |
[Modifications of neuroendocrine constellations and of various parenchyma due to varied doses of synthetic analgesics: experimental research with 1-methyl-4-(m-hydroxyphenyl)-4-propionyl-piperidine].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Endocrine Glands; Neurosecretory Systems; Piperidines | 1957 |
Pharmacology of some new unsymmetrical bisquaternary hypotensive agents; substituted pyridine and piperidine derivatives.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypotension; Piperidines; Pyridines | 1957 |
[Further results of new therapy of Parkinsonian syndromes; therapeutic action of 3-phenyl-3-b-diethylamino-ethyl-2-6-dioxy-piperidine hydrochloride administered alone and with reserpine and ritalin].
Topics: Methylphenidate; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders; Piperidines; Reserpine; Salts | 1957 |
[Determination of 1-methyl-4-amino-N'-phenyl-N'-(2-thenyl)-piperidine (sandostene-Sandoz)].
Topics: Anti-Allergic Agents; Histamine H1 Antagonists; Piperidines | 1957 |
[Some pyridine & piperidine derivatives of 4-chloro substituted diphenylmethane & their pharmacological properties].
Topics: Anti-Allergic Agents; Benzhydryl Compounds; Piperidines; Pyridines | 1957 |
[Piperidine-N-sulfonic acid and its betaines].
Topics: Betaine; Piperidines; Sulfonic Acids | 1958 |
[Clinical experiences with a new narcotic, or sedative, of the piperidine series].
Topics: Hypnotics and Sedatives; Narcotics; Piperidines | 1957 |
[Antihistaminic action of 1-[2-benzyl-N-phenyl) aminoethyl piperidine].
Topics: Histamine H1 Antagonists; Humans; Piperidines | 1958 |
[Spasmolytic effects of some alkylated pyridine and piperidine compounds].
Topics: Alkylation; Muscle Relaxants, Central; Parasympatholytics; Piperidines; Pyridines | 1958 |
[Studies on local anesthetics. XIX. Substituted phenylcarbamates of piperidine-propanediol I].
Topics: Anesthetics; Anesthetics, Local; Phenylcarbamates; Piperidines; Propylene Glycols | 1959 |
Plant enzyme reactions leading to the formation of heterocyclic compounds. 3. Plant amine oxidase and the formation of pyrrolidine and piperidine alkaloids.
Topics: Alkaloids; Amines; Oxidoreductases; Piperidines; Pyrroles; Pyrrolidines | 1959 |
[Practical method of rapid completion of labor with administration of 1-methyl-4-phenyl-piperidine-4-ethyl carboxylate hydrochloride (dolantin)].
Topics: Female; Humans; Labor, Obstetric; Meperidine; Piperidines; Pregnancy | 1959 |
Some aspects of the pharmacology of ethyl-4-phenyl-1-[2-(phenylamino)ethyl]-piperidine-4-carboxylate (Win 13,797).
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Piperidines | 1959 |
Distribution of piperidine in the brain and its possible significance in behavior.
Topics: Behavior; Brain; Humans; Piperidines | 1961 |
Anticonvulsant properties of 1-(1-phenylcyclohexyl) piperidine-HC1 and certain other drugs.
Topics: Anticonvulsants; Barbiturates; Hydantoins; Piperidines | 1961 |
[Use of a new piperidine hypnotic, N-phthalic glutamimide, in pediatric electroencephalography].
Topics: Child; Electroencephalography; Humans; Hypnotics and Sedatives; Infant; Piperidines | 1961 |
[On the Mannich reaction of 4-alkoxydesoxybenzoin with piperidine and the grouping of 4-alkylpiperidine to 4-alkoxymethylenedesoxybenzoin].
Topics: Benzoin; Piperidines | 1960 |
The pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl.
Topics: Central Nervous System; Piperidines | 1959 |
[Recent trends in the treatment of infantile encephalopathies with 1-piperidine-2-methyl-3, p-tolylpropane-3-one (Mydeton)].
Topics: Brain; Brain Diseases; Humans; Piperidines; Propiophenones; Tolperisone | 1962 |
[Production of 2-(beta-phenylethylamino)-piperidine and 2 -(beta-phenylethylamino)-thiazole].
Topics: Phenethylamines; Piperidines; Thiazoles | 1962 |
[Comparative pharmacological research on the methylenedisalicylates of hexamethylenetetramine and piperidine. IV. Behavior in the animal body].
Topics: Amines; Methenamine; Piperidines; Research; Salicylates | 1962 |
[Thin-layer chromatography of hemlock alkaloids and other piperidine bases].
Topics: Alkaloids; Chromatography, Thin Layer; Hemlock; Piperidines | 1963 |
[The use of a new synthetic anticholinergic agent with atropine-like action, N-methyl-N-(beta-dicyclohexyla-minoethyl)-piperidine in the therapy of dyskinesia of the biliarv tract].
Topics: Atropine; Biliary Dyskinesia; Cholinergic Antagonists; Dyskinesias; Humans; Parasympatholytics; Piperidines | 1963 |
[Fate of L-pipecolic acid and delta1-piperidine-2-carboxylic acid in the "sterile" white rat].
Topics: Animals; Carboxylic Acids; Lysine; Pipecolic Acids; Piperidines; Proteins; Rats | 1963 |
A modified method of preparing 1-methyl-4-phenyl-piperidine-4-carboxylic acid derivatives and pharmacological studies of its derivaties.
Topics: Carboxylic Acids; Piperidines; Research | 1963 |
[On the basicity of a series of bromides of N-methyl-N-(beta-aminoethyl)piperidine differently substituted on the tertiary nitrogen].
Topics: Bromides; Nitrogen; Piperidines | 1962 |
[The prepared method of 1-methyl-4-phenyl piperidine-4-carboxylic acid derivatives].
Topics: Carboxylic Acids; Meperidine; Piperidines | 1962 |
HYPOTENSIVE AGENTS. 2-(2AMINOETHYL)-PIPERIDINE DERIVATIVES.
Topics: Ammonium Compounds; Anti-Allergic Agents; Antihypertensive Agents; Chemical Phenomena; Chemistry; Dogs; Pharmacology; Piperidines; Quaternary Ammonium Compounds; Research | 1962 |
[ENZYMATIC SYNTHESES OF PYRROLIDINE- AND PIPERIDINE ALKALOIDS].
Topics: Alkaloids; Amines; Piperidines; Pyrroles; Pyrrolidines | 1963 |
[PHARMACOLOGICAL PROPERTIES OF SOME PIPERIDINE DERIVATIVES].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Cats; Guinea Pigs; Meperidine; Mice; Muscle, Smooth; Pharmacology; Piperidines; Pupil; Rabbits; Research; Toxicology | 1963 |
[1-METHYL-4-(N-2-THIENYLANILINO)-PIPERIDINE AND CALCIUM SALTS IN ALLERGIC RESPIRATORY PROBLEMS].
Topics: Anti-Allergic Agents; Calcium; Child; Histamine H1 Antagonists; Humans; Piperidines; Respiratory Hypersensitivity; Salts | 1964 |
[SYNTHESIS AND PHARMACOLOGICAL RESEARCH ON QUINUCLIDINE, PIPERIDINE AND PYRIDINE DERIVATIVES].
Topics: Chemistry, Pharmaceutical; Pharmacology; Pharmacy; Piperidines; Pyridines; Quinuclidines; Research | 1964 |
ACYLTRYPTAMINES. II. SYNTHESIS OF ACYLTRYPTAMINES, INDAZOLES, AND AZEPINOINDOLES FROM THE ACYLPHENYLHYDRAZONES OF 2,3-PIPERIDINEDIONE.
Topics: Antihypertensive Agents; Blood Pressure; Chemistry, Pharmaceutical; Dogs; Heterocyclic Compounds; Indazoles; Indoles; Mice; Pharmacology; Piperidines; Research; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin; Toxicology; Tryptamines | 1963 |
COMPARATIVE NEUROTOXICITY AND ANTIPENTYLENETETRAZOL ACTIVITY OF SOME PIPERIDINEDIONES.
Topics: Bemegride; Glutethimide; Hypnotics and Sedatives; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Piperidines; Research; Seizures; Toxicology | 1964 |
[FORMATION OF CO2-14 FROM LABELED LYSINE, DELTA-1-PIPERIDINE-2-CARBOXYLIC ACID AND PIPECOLIC ACID IN THE "STERILE" RAT].
Topics: Amino Acids; Biochemical Phenomena; Carbon Isotopes; Carboxylic Acids; Lysine; Metabolism; Pipecolic Acids; Piperidines; Radiometry; Rats; Research | 1964 |
DETERMINATION OF PYRROLIDINE AND PIPERIDINE.
Topics: Chromatography; Piperidines; Pyrroles; Pyrrolidines; Research; Spectrophotometry | 1964 |
[ON NEW WORKS ON THE BIOSYNTHESIS OF N-HETEROCYCLIC COMPOUNDS. 4. THE FORMATION OF COMPOUNDS WITH THE PYRIDINE-, PIPERIDINE-, QUINOLIZIDINE-, PYRROLIZIDINE- AND TROPANE RING SYSTEMS].
Topics: Chemistry, Pharmaceutical; Heterocyclic Compounds; Nortropanes; Piperidines; Pyridines; Pyrroles; Quinolizidines; Quinolizines; Research; Tropanes | 1964 |
[ACTION OF PC 63-I (PIPERIDINE 3,4-DIHYDROXYCINNAMATE) ON THE EFFECTS OF ACETYL-BETA-METHYLCHOLINE, VASOPRESSIN AND ALDOSTERONE].
Topics: Aldosterone; Arginine Vasopressin; Cinnamates; Diuresis; Methacholine Chloride; Methacholine Compounds; Neurosecretion; Pharmacology; Piperidines; Rats; Research; Vasopressins | 1964 |
[STUDIES WITH 1-(1'-PHENYLCYCLOHEXYL)-PIPERIDINE].
Topics: Anesthetics; Diagnosis, Differential; Hallucinogens; Humans; Neurotic Disorders; Phencyclidine; Piperidines; Psychopharmacology; Psychotic Disorders | 1964 |
[EXPERIMENTAL PSYCHOSIS INDUCED BY SERNYL (1-(1-PHENYLCYCLOHEXYL) PIPERIDINE. HC1)].
Topics: Anesthetics; Brain Chemistry; Pharmacology; Phencyclidine; Piperidines; Psychoses, Substance-Induced; Psychotic Disorders; Toxicology | 1964 |
DEMONSTRATION OF N-EPIMERS IN THE SALT OF A PIPERIDINE DERIVATIVE IN SOLUTION.
Topics: Chemistry, Pharmaceutical; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pharmaceutical Solutions; Piperidines; Research | 1965 |
[CLINICAL TRIAL OF A NEW NEUROLEPTIC IN LABOR. 4-(4-HYDROXY-4-PHENYL-PIPERIDINE)-BUTYROPHENONE].
Topics: Anesthesia; Anesthesia, Obstetrical; Antipsychotic Agents; Butyrophenones; Female; Haloperidol; Humans; Labor, Obstetric; Piperidines; Pregnancy | 1965 |
[ALPHA, OMEGA-SUBSTITUTED ALKANES WITH POSSIBLE BIOCHEMICAL SIGNIFICANCE. VI. SYNTHESIS OF PYRROLIDINE, PIPERIDINE AND HEXAMETHYLENE AMINE].
Topics: Alkanes; Amines; Chemistry, Pharmaceutical; Cyclohexanes; Piperidines; Pyrrolidines; Pyrrolidinones; Research | 1965 |
TANDEM PIPERIDINE AND DIMETHYL PHENOTHIAZINE TOXICITY IN A GERIATRIC PATIENT.
Topics: Drug Therapy; Geriatrics; Patients; Phenothiazines; Piperidines; Thioridazine; Toxicology | 1965 |
[ON THE USE OF A NEW ANTISPASTIC: ALPHA-PHENYL-ALPHA-(1-PIPERIDINE)-ACETATE OF BETA-PIPERIDINO-ETHYL-DIHYDROCHLORIDE, IN LABOR].
Topics: Acetates; Female; Humans; Labor, Obstetric; Muscle Relaxants, Central; Piperidines; Pregnancy | 1965 |
HETEROALICYCLIC AMINOALKANOL. I. SYNTHESES OF DL-2-PIPERIDINE-METHANOL AND MESO-CIS-2,6-PIPERIDINEDIMETHANOL AND REACTIONS OF INTERMEDIATES.
Topics: Alcohols; Chemistry, Pharmaceutical; Methanol; Piperidines; Pyridines; Research | 1965 |
[LATEST RESEARCH ON A NEW ANTISPASMODIC WITH PIPERIDINE STRUCTURE].
Topics: Cardiovascular Agents; Muscle Relaxants, Central; Parasympatholytics; Pharmacology; Piperidines; Rats; Research | 1965 |
[STUDIES ON APPEARANCE OF PHYSICAL DEPENDENCE OF 1-(2-ALPHA-(P-CHLOROPHENYL)BENZYLOXY-ETHYL)PIPERIDINE].
Topics: Antitussive Agents; Pharmacology; Piperidines; Rats; Research; Substance-Related Disorders; Toxicology | 1965 |
A clinical evaluation of a piperidine compound alone, and combined with calcium intravenously in antihistamine therapy.
Topics: Anti-Allergic Agents; Calcium; Histamine H1 Antagonists; Humans; Piperidines | 1955 |
A new, mild sedative-hypnotic, a piperidine derivative (noludar).
Topics: Anti-Allergic Agents; Hypnotics and Sedatives; Piperidines; Piperidones | 1955 |
[Noludar, a new soporific of the piperidine series].
Topics: Hypnotics and Sedatives; Piperidines; Piperidones | 1955 |
Observation on two psychotomimetic drugs of piperidine derivation--CI 395 (sernyl) and CI 400.
Topics: Anesthetics; Hallucinogens; Humans; Mental Disorders; Phencyclidine; Piperidines | 1960 |
Pharmacological actions of two new pethidine analogues.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Antipyretics; Meperidine; Piperidines | 1960 |
[Studies on the toxicology of barbiturates from the tetrahydro-pyridine and piperidine group].
Topics: Barbiturates; Humans; Hypnotics and Sedatives; Piperidines; Pyridines | 1959 |
[On the reinforcement of the sympathicolytic activity of tetrahydronorharman, by substitution of a closed tetramethylene chain for the hydrogen atom of the secondary amine grouping of its piperidine ring].
Topics: Amines; Heterocyclic Compounds; Hydrogen; Piperidines; Sympatholytics | 1960 |
[Comparative pharmacological research on hexamethylenetetramine-and piperidine-methylenedisalicylate. I. Minimal remote lethal dose].
Topics: Methenamine; Piperidines; Research; Salicylates | 1959 |
[Comparative pharmacological research on hexamethylenetetramine-and piperidine-methylenedisalicylate. II. Bacterial activity].
Topics: Humans; Methenamine; Piperidines; Research; Salicylates | 1959 |
[Comparative pharmacological research on the methylenedisalicylates of hexamethylenetetramine and piperidine. III. Effect on the isolated frog heart].
Topics: Animals; Anura; Heart; Methenamine; Piperidines; Ranidae; Salicylates | 1960 |
Long-distance radical cation reactions in DNA three-way junctions: inter-arm interaction and migration through the junction.
Topics: Anthraquinones; Base Sequence; Cations; DNA; Free Radicals; Ion Transport; Molecular Structure; Oxidation-Reduction; Photochemistry; Piperidines | 2003 |
Influence of pH on electrophoretic behavior of phenothiazines and determination of pKa values by capillary zone electrophoresis.
Topics: Buffers; Cyclodextrins; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Phenothiazines; Piperazine; Piperazines; Piperidines; Promethazine; Stereoisomerism | 2003 |
First synthesis of etidronate partial amides starting from PCl3.
Topics: Alkylation; Amides; Chemistry, Organic; Chlorides; Etidronic Acid; Magnetic Resonance Spectroscopy; Models, Chemical; Phosphorus Compounds; Piperidines | 2003 |
Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.
Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Cisplatin; Cross-Linking Reagents; DNA; DNA Adducts; DNA Repair; Female; High Mobility Group Proteins; Humans; Ligands; Oligodeoxyribonucleotides; Ovarian Neoplasms; Piperidines; Platinum Compounds; Sequence Analysis, DNA; Spain; Tumor Cells, Cultured | 2003 |
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.
Topics: Animals; Avoidance Learning; Biochemistry; Biological Availability; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Muscarinic Antagonists; ortho-Aminobenzoates; Piperidines; Rats; Receptor, Muscarinic M2; Structure-Activity Relationship | 2004 |
[Clinical experiences with persedon].
Topics: Humans; Hypnosis; Piperidines; Pyridones | 1950 |
Piperidine derivatives. I. Preparation of piperidine-2,6-dicarboxylic acid and its N-methyl derivative.
Topics: Anti-Allergic Agents; Dicarboxylic Acids; Piperidines | 1950 |
Piperidine derivatives. II. Preparation of 2,6-di-(alpha-hydroxybenzyl)-piperidine hydrochloride and related compounds.
Topics: Piperidines | 1950 |
The synthesis of certain disubstituted piperidines.
Topics: Piperidines | 1951 |
Studies on a new spasmolytic compound 1,1-diphenyl-3-dimethylaminobutene-1 (A29), related to methadone, and on the combined use of this compound and a potent analgesic, ketobemidone (A21).
Topics: Analgesics; Biphenyl Compounds; Humans; Meperidine; Methadone; Parasympatholytics; Piperidines | 1951 |
The structure of sedamine.
Topics: Alkaloids; Piperidines | 1951 |
Photometric determination of small amounts of piperidine.
Topics: Photometry; Piperidines | 1951 |
Effect of cadaverine and lysine on the urinary excretion of piperidine in rabbits.
Topics: Animals; Cadaverine; Lysine; Piperidines; Rabbits | 1951 |
[Chemical constitution and pharmacologic effect of a new series of gamma-substituted derivatives of piperidine with antihistaminic properties].
Topics: Histamine Antagonists; Piperidines | 1951 |
[Effect of soventol on hay fever and vasomotor rhinitis].
Topics: Humans; Piperidines; Rhinitis; Rhinitis, Allergic, Seasonal; Rhinitis, Vasomotor | 1951 |
Nisentil in 1,000 obstetric cases.
Topics: Alphaprodine; Female; Humans; Labor, Obstetric; Piperidines; Pregnancy | 1951 |
Cutaneous reactions produced by local administration of acetylcholine, acetyl-beta-methylcholine, piperidine and histamine.
Topics: Acetylcholine; Histamine; Histamine Agents; Humans; Methacholine Chloride; Pharmaceutical Preparations; Piperidines; Skin | 1952 |
The synthesis of some substituted pyridine and piperidine compounds from dipicolinic acid.
Topics: Picolinic Acids; Piperidines; Pyridines | 1952 |
Criteria for efficient transport of excess electrons in DNA.
Topics: Base Sequence; DNA; Electron Transport; Electrons; Molecular Sequence Data; Molecular Structure; Oligodeoxyribonucleotides; Photochemistry; Piperidines; Ultraviolet Rays | 2004 |
Cleavage of some annulated tetrahydropyridines under the action of dimethyl acetylene dicarboxylate in protic solvents. New practical route to substituted pyrroles and indoles.
Topics: Acetylene; Alcohols; Carboxylic Acids; Dioxanes; Indoles; Molecular Structure; Piperidines; Pyridines; Pyrroles; Solvents | 2003 |
Exploring the boundaries of a light-driven molecular motor design: new sterically overcrowded alkenes with preferred direction of rotation.
Topics: Alkenes; Circular Dichroism; Crystallography, X-Ray; Cyclization; Heterocyclic Compounds, 3-Ring; Hot Temperature; Hydrazones; Isomerism; Light; Models, Molecular; Molecular Conformation; Naphthalenes; Nitriles; Photochemistry; Piperidines; Rotation; Spectrophotometry, Ultraviolet; Stereoisomerism; Sulfhydryl Compounds; Sulfur Compounds; Thermodynamics | 2004 |
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Topics: Anti-HIV Agents; Binding Sites; CCR5 Receptor Antagonists; CD4 Antigens; Cell Line; Drug Design; Humans; Inhibitory Concentration 50; Piperidines; Receptors, CCR5; Stereoisomerism; Structure-Activity Relationship; Sulfones | 2004 |
Amidine derived 1,3-diazabuta-1,3-dienes as potential antibacterial and antifungal agents.
Topics: Alkylation; Amidines; Anti-Bacterial Agents; Antifungal Agents; Butadienes; Candida albicans; Gram-Negative Bacteria; Gram-Positive Bacteria; Isothiocyanates; Molecular Structure; Piperidines | 2004 |
Indolebutylamines as selective 5-HT(1A) agonists.
Topics: Animals; Biological Availability; Butylamines; Hippocampus; Humans; Indoles; Inhibitory Concentration 50; Male; Molecular Structure; Oxindoles; Piperidines; Pyridines; Rats; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Substrate Specificity | 2004 |
DNA interstrand cross-linking by a mycotoxic diepoxide.
Topics: Alkynes; Base Sequence; Cross-Linking Reagents; Cytotoxins; DNA; Epoxy Compounds; Molecular Sequence Data; Piperidines; Structure-Activity Relationship | 2004 |
The effect of banocide on adult forms and microfilariae of Loa loa.
Topics: Animals; Filariasis; Loa; Microfilariae; Piperidines | 1950 |
Studies on the pharmacology and toxicology of di-alpha-1,3-dimethyl-4-propionoxy piperidine (Nu-1196).
Topics: Piperazines; Piperidines | 1950 |
Characterization and crystal structure of cadmium(II) halide complexes with amino acids and their derivatives VI. The comparison of crystal structures of cadmium(II) halide complexes with three kinds of piperidine carboxylic acids.
Topics: Amino Acids; Cadmium; Carboxylic Acids; Ligands; Molecular Conformation; Piperidines; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Water; X-Ray Diffraction | 2004 |
Electron transfer in DNA duplexes containing 2-methyl-1,4-naphthoquinone.
Topics: Chromatography, High Pressure Liquid; DNA; DNA Damage; Electrons; Electrophoresis, Polyacrylamide Gel; Oligonucleotides; Piperidines; Ultraviolet Rays; Vitamin K 3 | 2004 |
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Topics: Acetazolamide; Amines; Biomarkers, Tumor; Carbonic Anhydrase Inhibitors; Catalysis; Cytosol; Heterocyclic Compounds; Humans; Isoenzymes; Morpholines; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Sulfanilamide; Sulfanilamides | 2005 |
Origin of the heterogeneous distribution of the yield of guanyl radical in UV laser photolyzed DNA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Base Sequence; Biophysical Phenomena; Biophysics; Cations; Deoxyguanosine; Dimerization; DNA; DNA-Formamidopyrimidine Glycosylase; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Free Radicals; Guanine; Ions; Lasers; Models, Chemical; Models, Statistical; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides; Oxazolone; Oxygen; Photolysis; Photons; Piperidines; Polymers; Pyrimidine Dimers; RNA; Spectrophotometry; Temperature; Ultraviolet Rays | 2005 |
Development of a flexible approach to Nuphar alkaloids via two enantiospecific piperidine-forming reactions.
Topics: Alkaloids; Catalysis; Combinatorial Chemistry Techniques; Lactams; Molecular Structure; Nuphar; Palladium; Piperidines; Plants, Medicinal; Quinolizines; Stereoisomerism | 2005 |
Truncated azinomycin analogues intercalate into DNA.
Topics: Antibiotics, Antineoplastic; Azabicyclo Compounds; Cell Line, Tumor; Cell Survival; Dipeptides; DNA; Glycopeptides; Humans; Intercalating Agents; Nucleic Acid Denaturation; Piperidines; Structure-Activity Relationship | 2005 |
Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Butylamines; Cations; Cisplatin; DNA; Leishmania infantum; Molecular Sequence Data; Picolines; Piperazine; Piperazines; Piperidines; Platinum Compounds; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Ubiquitin; Water | 2005 |
Oxidatively induced DNA-protein cross-linking between single-stranded binding protein and oligodeoxynucleotides containing 8-oxo-7,8-dihydro-2'-deoxyguanosine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amino Acids; Base Sequence; Binding Sites; Cross-Linking Reagents; Deoxyguanosine; DNA Adducts; DNA-Binding Proteins; DNA, Bacterial; DNA, Single-Stranded; Escherichia coli; Escherichia coli Proteins; Hot Temperature; Hydrogen-Ion Concentration; Macromolecular Substances; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Piperidines; Protein Conformation; Spectrometry, Mass, Electrospray Ionization | 2005 |
Adsorption of 4-picoline and piperidine to the hydrated SiO2 surface: probing the surface acidity with vibrational sum frequency generation spectroscopy.
Topics: Adsorption; Air Pollutants; Hydrogen-Ion Concentration; Picolines; Piperidines; Silicon Dioxide; Spectrum Analysis; Volatilization | 2005 |
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Flowers; Male; Mice; Molecular Structure; Muscarinic Antagonists; Piperidines; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Scopolamine; Structure-Activity Relationship | 2005 |
Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity.
Topics: Amino Acid Sequence; Directed Molecular Evolution; DNA; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Nucleic Acids; Piperidines; Proline; Pyrrolidines; RNA; Substrate Specificity | 2005 |
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.
Topics: Cell Line; Dopamine Agonists; Humans; Ligands; Molecular Structure; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship | 2005 |
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Diltiazem; Drug Design; Male; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Rats, Wistar; Salicylamides; Structure-Activity Relationship | 2005 |
Nucleotide exchange and excision technology (NExT) DNA shuffling: a robust method for DNA fragmentation and directed evolution.
Topics: Chloramphenicol O-Acetyltransferase; Deoxyribonuclease (Pyrimidine Dimer); Deoxyuracil Nucleotides; Directed Molecular Evolution; DNA Fragmentation; DNA Shuffling; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Gene Library; Nucleotides; Piperidines; Polymerase Chain Reaction; Software; Taq Polymerase; Thymine Nucleotides | 2005 |
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides.
Topics: Animals; Benzeneacetamides; Biological Availability; CCR5 Receptor Antagonists; Humans; Inhibitory Concentration 50; Ligands; Molecular Structure; Piperidines; Rats; Receptors, CCR5; Structure-Activity Relationship | 2005 |
Synthesis and spectral studies of [RuCl(CO)(L)(PPh3)(B)] (HL = 2'-hydroxychalcones and B = PPh3, pyridine or piperidine) and their catalytic and biological applications.
Topics: Anti-Bacterial Agents; Antifungal Agents; Aspergillus fumigatus; Carbon Monoxide; Catalysis; Chalcones; Chlorides; Gram-Negative Bacteria; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Piperidines; Pyridines; Ruthenium; Staphylococcaceae | 2005 |
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.
Topics: Administration, Oral; Animals; Anti-Obesity Agents; Humans; Indazoles; Mice; Piperidines; Receptors, Somatostatin; Tissue Distribution | 2005 |
Guanine-specific DNA damage photosensitized by the dihydroxo(tetraphenylporphyrinato)antimony(V) complex.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Deoxyguanosine; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase; DNA, Single-Stranded; Electron Transport; Escherichia coli Proteins; Guanine; Light; Membrane Lipids; Metalloporphyrins; Oxidation-Reduction; Phospholipids; Photosensitizing Agents; Piperidines; Proteins; Singlet Oxygen | 2006 |
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists.
Topics: Binding, Competitive; Drug Design; Drug Industry; Imidazoles; Kinetics; Models, Chemical; Peptides; Piperidines; Receptors, Opioid, delta; Structure-Activity Relationship | 2006 |
The synthesis of curved and linear structures from a minimal set of monomers.
Topics: Amino Acids; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidines; Stereoisomerism | 2005 |
p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.
Topics: Animals; Arthritis, Experimental; Collagen; Dexamethasone; Dogs; Enzyme Inhibitors; Haplorhini; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Models, Chemical; Naphthyridines; p38 Mitogen-Activated Protein Kinases; Piperidines; Quinolones; Rats; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Synthesis of novel piperidinyl linker based energy transfer terminators and their potential use in DNA sequencing.
Topics: DNA; DNA-Directed DNA Polymerase; Energy Transfer; Fluorescent Dyes; Hot Temperature; Indicators and Reagents; Models, Chemical; Nucleic Acid Conformation; Nucleic Acid Denaturation; Piperidines; Sequence Analysis, DNA; Spectrometry, Fluorescence | 2005 |
Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series.
Topics: Animals; Benzimidazoles; Binding Sites; Brain; Cells, Cultured; Chlorophenols; Histamine Antagonists; Imidazoles; Piperidines; Rats; Receptors, Histamine H3; Structure-Activity Relationship | 2006 |
Aminolysis of 2,4-dinitrophenyl X-substituted benzoates and Y-substituted phenyl benzoates in MeCN: effect of the reaction medium on rate and mechanism.
Topics: Acetonitriles; Amines; Benzoates; Kinetics; Morpholines; Piperidines | 2006 |
Natural and synthetic G-quadruplex interactive berberine derivatives.
Topics: Antineoplastic Agents; Berberine Alkaloids; DNA; Humans; Intercalating Agents; Ligands; Nucleic Acid Denaturation; Nucleic Acid Heteroduplexes; Piperidines; Telomerase; Telomere | 2006 |
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Cathepsins; Cell Line, Tumor; Enzyme Inhibitors; Mice; Piperidines; Structure-Activity Relationship | 2006 |
A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bradykinin B1 Receptor Antagonists; Inhibitory Concentration 50; Piperidines; Rats; Structure-Activity Relationship; Tetrahydronaphthalenes | 2006 |
Singular value decomposition of torsional angles of analogs of the dopamine reuptake inhibitor GBR 12909.
Topics: Computer Simulation; Dopamine Uptake Inhibitors; Molecular Structure; Piperazine; Piperazines; Piperidines | 2006 |
Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Biological Clocks; Dose-Response Relationship, Drug; Drug Interactions; Flufenamic Acid; In Vitro Techniques; Ketanserin; Mice; Nerve Net; Neurons; Oxygen; Patch-Clamp Techniques; Piperidines; Receptor, Serotonin, 5-HT2A; Respiratory Burst; Respiratory Center; Respiratory Mechanics; Serotonin Antagonists; Substance P; Synaptic Transmission; Time Factors | 2006 |
Structure-activity relationship of cyclic nitroxides as SOD mimics and scavengers of nitrogen dioxide and carbonate radicals.
Topics: Antioxidants; Carbonates; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Molecular Mimicry; Nitrogen Dioxide; Oxazoles; Oxidation-Reduction; Piperidines; Pulse Radiolysis; Pyrrolidines; Structure-Activity Relationship; Superoxide Dismutase; Superoxides | 2006 |
The discovery of tropane-derived CCR5 receptor antagonists.
Topics: Anti-HIV Agents; CCR5 Receptor Antagonists; Cytochrome P-450 CYP2D6 Inhibitors; HIV-1; Humans; Models, Molecular; Piperidines; Receptors, CCR5; Structure-Activity Relationship; Tropanes | 2006 |
Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Calcium Channel Blockers; Cattle; Copper; Deoxyguanosine; DNA Damage; DNA Fragmentation; Dopamine; Edetic Acid; Ferric Compounds; Free Radical Scavengers; HL-60 Cells; Humans; Ions; Iron Chelating Agents; Metals; Molecular Structure; Phenanthrolines; Piperidines; Tetrahydropapaveroline | 2006 |
Stereocontrolled synthesis of the D- and L-glycero-beta-D-manno-heptopyranosides and their 6-deoxy analogues. Synthesis of methyl alpha-l-rhamno-pyranosyl-(1-->3)-D-glycero-beta-D-manno-heptopyranosyl- (1-->3)-6-deoxy-glycero-beta-D-manno-heptopyranosyl-(
Topics: Acetals; Alkenes; Azo Compounds; Carbohydrate Conformation; Carbohydrate Sequence; Deoxy Sugars; Glycosylation; Heptoses; Lipopolysaccharides; Mesylates; Methylglycosides; Models, Chemical; Molecular Sequence Data; Nitriles; Oligosaccharides; Piperidines; Plesiomonas; Rhamnose; Stereoisomerism; Sulfinic Acids; Trialkyltin Compounds | 2006 |
Comparative QSAR modeling of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.
Topics: Amides; Piperidines; Quantitative Structure-Activity Relationship; Receptors, CCR5; Urea | 2006 |
Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100.
Topics: Amines; Amino Acid Sequence; Biodegradation, Environmental; Catalysis; Glutaral; Molecular Sequence Data; Molecular Structure; Morpholines; Mycobacterium; Piperidines; Pyrrolidines; Rhodococcus; RNA, Ribosomal, 16S; Sewage; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Succinate-Semialdehyde Dehydrogenase | 2006 |
Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines.
Topics: Amination; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Inhibitory Concentration 50; Molecular Structure; Piperidines; Protease Inhibitors; Stereoisomerism | 2006 |
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.
Topics: Benzodiazepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Cyclic AMP; Drug Stability; Humans; Migraine Disorders; Piperidines; Protein Binding; Structure-Activity Relationship | 2006 |
Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp. strain THO100 isolated from a morpholine-containing culture of activated sewage sludge.
Topics: Amines; Biodegradation, Environmental; Genes, Bacterial; Germany; Industrial Microbiology; Morpholines; Multigene Family; Mycobacterium; Phylogeny; Piperidines; Pyrrolidines; Sequence Homology; Sewage; Species Specificity; Waste Disposal, Fluid | 2006 |
Anti-cancer activities of 5-acyl-6-[2-hydroxy/benzyloxy-3-(amino)-propylamino]-1,3-dialkyl-1H-pyrimidin-2,4-diones.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Neoplasms; Piperidines; Propanolamines; Pyrimidines; Pyrimidinones; Pyrrolidines; Structure-Activity Relationship | 2006 |
Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.
Topics: Amides; Animals; Benzamides; Glycine Plasma Membrane Transport Proteins; Humans; Methylation; Mice; Molecular Structure; Morpholines; Piperidines; Rats; Structure-Activity Relationship | 2006 |
Access to piperidine imino-C-glycosides via stereoselective thiazole-based aminohomologation of pyranoses.
Topics: Amines; Glycosides; Imino Sugars; Monosaccharides; Piperidines; Stereoisomerism; Thiazoles | 2006 |
Hydroaminomethylation with novel rhodium-carbene complexes: an efficient catalytic approach to pharmaceuticals.
Topics: Alkenes; Amines; Catalysis; Hydrocarbons; Imidazoles; Ligands; Methane; Methylation; Models, Chemical; Molecular Structure; Organometallic Compounds; Pharmaceutical Preparations; Piperidines; Propane; Rhodium; Styrenes | 2007 |
Mechanistic studies of the copper-catalyzed electrophilic amination of diorganozinc reagents and development of a zinc-free protocol.
Topics: Amination; Bromides; Catalysis; Copper; Cyclization; Electrons; Molecular Structure; Piperidines; Zinc | 2007 |
Ether-directed, stereoselective aza-Claisen rearrangements: synthesis of the piperidine alkaloid, alpha-conhydrine.
Topics: Alkaloids; Aza Compounds; Ether; Molecular Structure; Piperidines; Propanols; Pyrrolidines; Stereoisomerism | 2007 |
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors.
Topics: Catalytic Domain; Cathepsins; Chemistry, Pharmaceutical; Dipeptides; Drug Design; Humans; Models, Chemical; Molecular Conformation; Nitriles; Peptides; Piperidines; Pyrrolidines; Structure-Activity Relationship | 2007 |
Spectroscopic and kinetic evidence for an accumulating intermediate in an SNV reaction with amine nucleophiles. Reaction of methyl beta-methylthio-alpha-nitrocinnamate with piperidine and morpholine.
Topics: Amines; Cinnamates; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Morpholines; Nitro Compounds; Piperidines; Spectrophotometry, Ultraviolet | 2007 |
Pyrrolidine and piperidine formation via copper(II) carboxylate-promoted intramolecular carboamination of unactivated olefins: diastereoselectivity and mechanism.
Topics: Alkenes; Amination; Carboxylic Acids; Copper; Crystallography, X-Ray; Cyclization; Free Radicals; Models, Molecular; Molecular Structure; Nitrogen; Oxidation-Reduction; Piperidines; Pyrrolidines; Solvents; Stereoisomerism; Sulfonamides; Temperature; Water | 2007 |
Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Amides; Binding Sites; Enzyme Inhibitors; Humans; Immunoenzyme Techniques; Models, Chemical; Piperidines; Structure-Activity Relationship | 2007 |
Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2.
Topics: Animals; Apoptosis; Cell Death; Cells, Cultured; DNA Damage; Dose-Response Relationship, Drug; Neurons; Neuroprotective Agents; Piperidines; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, sigma | 2007 |
Development of an electrolytic system for non-Kolbe electrolysis based on the acid-base reaction between carboxylic acids as a substrate and solid-supported bases.
Topics: Alanine; Carboxylic Acids; Electrolysis; Methanol; Piperidines; Proline; Silica Gel; Silicon Dioxide | 2007 |
Asymmetric alpha-alkynylation of piperidine via N-sulfinyliminium salts.
Topics: Alkynes; Aluminum Compounds; Imines; Methylation; Molecular Structure; Piperidines; Salts; Stereoisomerism; Sulfur | 2007 |
An efficient synthesis of nitroalkenes by alkene cross metathesis: facile access to small ring systems.
Topics: Alkenes; Cyclization; Cyclopentanes; Indicators and Reagents; Isoxazoles; Nitro Compounds; Piperidines | 2007 |
5-Bromodeoxyuridine radiosensitization: conformation-dependent DNA damage.
Topics: Base Sequence; Bromodeoxyuridine; DNA; DNA Breaks; DNA Damage; DNA, Single-Stranded; Ethanol; Gamma Rays; Models, Biological; Nitrous Oxide; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Piperidines; Radiation-Sensitizing Agents; Water | 2007 |
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Molecular Structure; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Structure-Activity Relationship | 2007 |
First asymmetric synthesis of trans-3,4-dimethyl-4-arylpiperidines.
Topics: Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Narcotic Antagonists; Piperidines; Receptors, Opioid; Stereoisomerism | 2007 |
Synthesis and glycosylation of a series of 6-mono-, di-, and trifluoro S-phenyl 2,3,4-tri-O-benzyl-thiorhamnopyranosides. Effect of the fluorine substituents on glycosylation stereoselectivity.
Topics: Benzylidene Compounds; Carbohydrate Conformation; Carbohydrate Sequence; Fluorine; Furans; Glycosylation; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Piperidines; Rhamnose; Stereoisomerism; Sulfonamides; Thioglycosides | 2007 |
Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
Topics: Alkanes; Amides; Humans; Molecular Structure; Nitriles; Piperidines; Receptor, Melanocortin, Type 4; Structure-Activity Relationship; Tetrazoles | 2007 |
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
Topics: Boronic Acids; Carbon; Catalysis; Esters; Hydrocarbons, Aromatic; Hydroxyproline; Ketones; Models, Chemical; Piperidines; Proline; Pyrrolidines; Ruthenium; Stereoisomerism | 2007 |
Development of CXCR3 antagonists. Part 2: Identification of 2-amino(4-piperidinyl)azoles as potent CXCR3 antagonists.
Topics: Amination; Animals; Azoles; CHO Cells; Cricetinae; Cricetulus; Humans; Mice; Models, Molecular; Molecular Structure; Piperidines; Receptors, CXCR3; Structure-Activity Relationship; Water | 2007 |
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.
Topics: Acylation; Animals; Cognition; Drug Design; Mice; Molecular Structure; Piperidines; Structure-Activity Relationship; Sulfur | 2008 |
Fluorescence studies of selected 2-alkylaminopyrimidines.
Topics: Fluorescence; Piperidines; Pyrimidines; Solvents | 2004 |
One-electron oxidation and reduction potentials of nitroxide antioxidants: a theoretical study.
Topics: Antioxidants; Electrodes; Electrons; Models, Chemical; Nitrogen Oxides; Oxazoles; Oxidation-Reduction; Piperidines; Pyrrolidines; Thermodynamics | 2007 |
The use of piperidione as a cough sedative.
Topics: Cough; Humans; Hypnotics and Sedatives; Piperidines | 1948 |
Curariform activity and chemical structure; syntheses in the piperidine series.
Topics: Piperidines | 1949 |
The preparation of some piperidine derivatives by the Mannich reaction.
Topics: Piperidines | 1948 |
Research on the electrolytic hydrogenation of pyridine to piperidine; Energetic differences between hydrogenation and electrolytic reduction.
Topics: Piperidines; Pyridines | 1949 |
Morphine studies; the synthesis of a tetralin-piperidine fused-ring system.
Topics: Morphine; Piperidines; Tetrahydronaphthalenes | 1949 |
Action of 1-methyl-4-3(3-hydroxyphenyl)-4-piperidyl ethyl ketone on the gastrointestinal tract.
Topics: Gastrointestinal Tract; Humans; Ketones; Piperidines | 1949 |
Some pharmacological actions of piperidine, pyrrolidine, and of pressor concentrates from dog urine.
Topics: Animals; Dogs; Piperidines; Pyrroles; Pyrrolidines; Quinidine | 1949 |
Electrical detection of amine ligation to a metalloporphyrin via a hybrid SOI-MOSFET.
Topics: Amines; Electrochemistry; Hydrogen-Ion Concentration; Kinetics; Light; Metalloporphyrins; Models, Molecular; Oxides; Piperidines; Pyridines; Semiconductors; Silicon; Volatilization; Zinc | 2008 |
Density functional theory study of piperidine and diazocine compounds.
Topics: Nitro Compounds; Piperidines; Thermodynamics | 2008 |
Methylation and uracil interference assays for analysis of protein-DNA interactions.
Topics: Animals; Autoradiography; Binding Sites; DNA; DNA Methylation; DNA Probes; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Humans; Piperidines; Polymerase Chain Reaction; Protein Binding; Uracil; Uracil-DNA Glycosidase | 2001 |
Identification of novel series of human CCR1 antagonists.
Topics: Calcium; Cell Line; Cell Movement; Chemokine CCL3; Chemotaxis; Humans; Molecular Structure; Monocytes; Piperidines; Receptors, CCR1; Structure-Activity Relationship | 2008 |
DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest.
Topics: Aminoacridines; Cell Cycle; Cell Line, Tumor; Dimerization; DNA; Humans; Molecular Structure; Piperidines; Structure-Activity Relationship | 2008 |
Synthesis of gamma-hydroxyalkyl substituted piperidine iminosugars from D-glucose.
Topics: Alkylation; Glucose; Hydroxylation; Imino Sugars; Molecular Structure; Piperidines | 2008 |
Proline derived spirobarbiturates as highly effective beta-turn mimetics incorporating polar and functionalizable constraint elements.
Topics: Barbiturates; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Piperidines; Proline; Spiro Compounds | 2008 |
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Dogs; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Models, Molecular; Molecular Structure; Piperidines; Rats; Structure-Activity Relationship; Thiazoles; Xenograft Model Antitumor Assays | 2008 |
Transdermal therapeutic system of enalapril maleate using piperidine as penetration enhancer.
Topics: Acrylates; Administration, Cutaneous; Animals; Antihypertensive Agents; Biological Availability; Blood Pressure; Disease Models, Animal; Drug Stability; Drug Storage; Enalapril; Excipients; Female; Hypertension; Male; Permeability; Piperidines; Polymers; Povidone; Rats; Skin Absorption | 2008 |
Probing nucleic acid structure with nickel- and cobalt-based reagents.
Topics: Biochemistry; Cobalt; DNA; Guanine; Indicators and Reagents; Nickel; Nucleic Acids; Oxidation-Reduction; Piperidines | 2001 |
Chemical reagents for investigating the major groove of DNA.
Topics: Base Pairing; Base Sequence; Biochemistry; DNA; DNA Methylation; DNA Probes; G-Quadruplexes; Hot Temperature; Indicators and Reagents; Molecular Sequence Data; Nucleic Acid Conformation; Oxidation-Reduction; Piperidines; Proteins | 2001 |
Detection and characterization of cyclic hydroxylamine adducts by mass spectrometry.
Topics: Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxyl Radical; Hydroxylamine; Ions; Mass Spectrometry; Models, Chemical; Peptides; Phospholipids; Piperidines; Pyrrolidines; Spectrometry, Mass, Electrospray Ionization; Spin Labels; Spin Trapping | 2008 |
Design, synthesis, and structure-activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine.
Topics: Binding, Competitive; Chemistry, Pharmaceutical; Drug Design; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Conformation; Molecular Structure; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Protein Binding; Receptors, Opioid; Spiro Compounds; Structure-Activity Relationship | 2008 |
Aryl triolborates: novel reagent for copper-catalyzed N arylation of amines, anilines, and imidazoles.
Topics: Amines; Aniline Compounds; Borates; Catalysis; Copper; Hydrogen; Imidazoles; Molecular Structure; Nitrogen; Piperidines | 2008 |
Acute corrosion of the oral mucosa in a dog due to ingestion of Multicolored Asian Lady Beetles (Harmonia axyridis: Coccinellidae).
Topics: Animals; Burns, Chemical; Coleoptera; Dog Diseases; Dogs; Hemolymph; Insect Bites and Stings; Mouth Mucosa; Piperidines; Tongue | 2008 |
Determination of the degree of charge-transfer contributions to surface-enhanced Raman spectroscopy.
Topics: Chemistry, Physical; Electrons; Ethylenes; Nitriles; Phenols; Piperidines; Spectrum Analysis, Raman; Sulfhydryl Compounds; Surface Plasmon Resonance | 2008 |
Growth inhibition of human colon cancer cells by plant compounds.
Topics: Acrolein; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Piperidines; Plant Extracts; Resveratrol; Stilbenes | 2008 |
Enantioselective total syntheses of nankakurines A and B: confirmation of structure and establishment of absolute configuration.
Topics: Alkaloids; Aza Compounds; Azo Compounds; Heterocyclic Compounds, Bridged-Ring; Imines; Lycopodium; Models, Chemical; Piperidines; Stereoisomerism; Thiosemicarbazones | 2008 |
Experimental and theoretical studies of the redox potentials of cyclic nitroxides.
Topics: Acetonitriles; Algorithms; Aza Compounds; Cyclic N-Oxides; Electrochemistry; Isoindoles; Models, Theoretical; Oxidation-Reduction; Piperidines; Pyrrolidines | 2008 |
Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.
Topics: Imines; Lactams; Piperidines; Stereoisomerism; Substrate Specificity | 2008 |
Anticancer properties of 2-piperidyl analogues of the natural indole phytoalexin 1-methoxyspirobrassinol.
Topics: Antineoplastic Agents; Biological Products; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Humans; Indoles; Molecular Structure; Piperidines; Spiro Compounds; Structure-Activity Relationship | 2008 |
The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.
Topics: 17-Hydroxysteroid Dehydrogenases; Azepines; Catalytic Domain; Cell Line; Drug Design; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Piperidines; Structural Homology, Protein | 2009 |
Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1.
Topics: Antiviral Agents; Drug Evaluation, Preclinical; HIV-1; Ligands; Molecular Structure; Piperidines; Receptors, CCR5; Structure-Activity Relationship | 2008 |
Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].
Topics: Alkylation; Animals; Cyclization; Ligands; Mice; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pain; Piperidines; Protein Binding; Pyrans; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes | 2008 |
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cardiovascular System; Drug Evaluation, Preclinical; Humans; Molecular Structure; Piperidines; Rats; Structure-Activity Relationship | 2008 |
Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen.
Topics: Allosteric Regulation; Allosteric Site; Amides; Benzimidazoles; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Chemical; Nitrogen; Piperidines; Receptor, Muscarinic M1; Structure-Activity Relationship; Sulfonamides; Urea | 2008 |
Piperidine derivatives; the condensation of aromatic aldehydes with l-methyl-4-piperidone.
Topics: Aldehydes; Piperidines; Piperidones | 1948 |
Experiments in the piperidine series.
Topics: Humans; Piperidines | 1948 |
New piperidine derivatives as local anesthetics.
Topics: Anesthesia; Anesthesiology; Anesthetics, Local; Piperidines | 1948 |
Pharmacological studies on analgesic piperidine derivatives.
Topics: Analgesics; Piperidines | 1948 |
Human studies on analgesic piperidine derivatives.
Topics: Analgesics; Anti-Allergic Agents; Humans; Piperidines | 1948 |
Piperidine derivatives; 2-phenyl- and 2-phenylalkyl-piperidines.
Topics: Piperidines | 1947 |
Piperidine derivatives; 4-arylpiperidines.
Topics: Piperidines | 1947 |
Piperidine derivatives; 4-alkyl-, 4-cycloalkyl-, and 4-heterocyclyl-piperidines.
Topics: Piperidines | 1947 |
Piperidine derivatives; 1,3-dialkyl-4-aryl-4-acyloxypiperidines.
Topics: Piperidines | 1947 |
Synthesis and DNA interactions of a bis-phenothiazinium photosensitizer.
Topics: DNA; DNA Cleavage; Electrons; Indicators and Reagents; Intercalating Agents; Nucleic Acid Denaturation; Nucleotides; Phenothiazines; Photochemistry; Photosensitizing Agents; Piperidines; Spectrophotometry, Ultraviolet; Transition Temperature; Viscosity | 2008 |
N-(acetylsalicyloyl)-piperidine.
Topics: Piperidines | 1948 |
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
Topics: Animals; Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Lobeline; Models, Chemical; Oxygen; Piperidines; Rats; Structure-Activity Relationship; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2008 |
Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.
Topics: Alcohols; Binding Sites; Chemistry, Pharmaceutical; Chemokine CCL2; Drug Design; Humans; Indoles; Inhibitory Concentration 50; Molecular Structure; Piperidines; Receptors, CCR2; Stereoisomerism; Structure-Activity Relationship | 2008 |
Silver ion-induced Grob fragmentation of gamma-amino iodides: highly stereoselective synthesis of polysubstituted piperidines.
Topics: Iodides; Piperidines; Silver; Stereoisomerism; Substrate Specificity | 2008 |
Synthesis and in-vitro activity of new 1beta-methylcarbapenem derivatives as antibacterial agents.
Topics: Anti-Bacterial Agents; Carbapenems; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Piperidines; Pyrrolidines; Structure-Activity Relationship | 2008 |
Genetic variation of piperidine alkaloids in Pinus ponderosa: a common garden study.
Topics: Alkaloids; Climate; Genetic Variation; Geography; Least-Squares Analysis; Likelihood Functions; Models, Biological; Pacific States; Pinus ponderosa; Piperidines; Plant Extracts; Plant Leaves; Seedlings | 2009 |
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
Topics: Animals; Cell Line, Tumor; Genes, Reporter; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Isomerism; Mice; Molecular Structure; Piperidines; Protein Binding; Proteins; Signal Transduction; Skull; Structure-Activity Relationship; Sulfanilamides; Wnt Proteins | 2009 |
Hydroformylation of homoallylic azides: a rapid approach toward alkaloids.
Topics: Alkaloids; Azides; Piperidines; Time Factors | 2009 |
Direct electrochemical alpha-cyanation of N-protected cyclic amines.
Topics: Amines; Cyanates; Electrochemistry; Molecular Structure; Oxidation-Reduction; Piperidines; Pyrrolidines; Stereoisomerism | 2009 |
Enaminones as building blocks in heterocyclic syntheses: reinvestigating the product structures of enaminones with malononitrile. A novel route to 6-substituted-3-oxo-2,3-dihydropyridazine-4-carboxylic acids.
Topics: Carboxylic Acids; Ethanol; Nitriles; Piperidines; Pyridazines | 2008 |
Characterization of diverse heterocyclic amine-degrading denitrifying bacteria from various environments.
Topics: Anaerobiosis; Biodegradation, Environmental; Genes, rRNA; Nitrates; Nitrite Reductases; Phenotype; Phylogeny; Piperidines; Proteobacteria; Pyrrolidines; RNA, Bacterial; RNA, Ribosomal, 16S | 2009 |
The identification of orally bioavailable thrombopoietin agonists.
Topics: Administration, Oral; Animals; Benzoates; Biological Availability; Caco-2 Cells; Humans; Hydrazines; Piperidines; Pyrazinamide; Pyrazoles; Pyrimidines; Rats; Receptors, Thrombopoietin | 2009 |
Synthesis of new aza-analogs of staurosporine, K-252a and rebeccamycin by nucleophilic opening of C2-symmetric bis-aziridines.
Topics: Aza Compounds; Aziridines; Drug Stability; Piperidines; Pyrrolidines; Solubility; Staurosporine | 2009 |
Antioxidant effects of a Rhodobryum roseum extract and its active components in isoproterenol-induced myocardial injury in rats and cardiac myocytes against oxidative stress-triggered damage.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Antioxidants; Aspartate Aminotransferases; Bryophyta; Cardiomyopathies; Cell Survival; Creatine Kinase; Dioxolanes; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Isoproterenol; L-Lactate Dehydrogenase; Myocytes, Cardiac; Oxidants; Oxidative Stress; Piperidines; Rats | 2009 |
[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring.
Topics: Animals; Anti-HIV Agents; CCR5 Receptor Antagonists; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cricetulus; Drug Design; HIV Infections; HIV-1; Inhibitory Concentration 50; Molecular Conformation; Piperidines; Protein Structure, Tertiary; Rats; Receptors, CCR5 | 2009 |
Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands.
Topics: Ethers; Humans; Ligands; Molecular Structure; Piperidines; Receptors, Histamine H3 | 2009 |
Rearrangemements in piperidine-derived nitrogen-centered radicals. A quantum-chemical study.
Topics: Anions; Cations; Computer Simulation; Hydrogen; Kinetics; Molecular Structure; Nitrogen; Piperidines; Quantum Theory | 2009 |
Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.
Topics: Animals; Binding, Competitive; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Calcium; Cell Line; Drug Discovery; Electric Conductivity; Humans; Imipramine; Immobilized Proteins; Ion Channel Gating; Kinetics; Mice; Models, Molecular; Muscles; Nicotinic Antagonists; Piperidines; Protein Binding; Protein Conformation; Pyridines; Receptors, Nicotinic; Thermodynamics; Torpedo | 2009 |
Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)piperidine-4-carboxamides.
Topics: Animals; Cardiotonic Agents; Chemistry, Organic; Chemistry, Pharmaceutical; Drug Design; Heart; Isonipecotic Acids; Milrinone; Models, Chemical; Myocardium; Piperidines; Quinolines; Rabbits | 2009 |
Design and synthesis of piperidine-containing sphingoid base analogues.
Topics: Drug Design; Molecular Conformation; Piperidines; Sphingosine | 2009 |
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Crystallography, X-Ray; Endocannabinoids; Enzyme Inhibitors; Humans; Male; Pain; Piperazine; Piperazines; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Structure-Activity Relationship; Urea | 2009 |
The 2:1 salt-type adduct formed between 6-amino-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione and piperidine: sheets containing 20 independent hydrogen bonds.
Topics: Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Piperidines; Pyrimidinones | 2009 |
Asymmetric synthesis of (+)-castanospermine through enol ether metathesis-hydroboration/oxidation.
Topics: Alkaloids; Catalysis; Cyclization; Ether; Ethers; Indolizines; Oxidation-Reduction; Piperidines; Stereoisomerism | 2009 |
Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: alleviating hERG interactions through structure based design.
Topics: Drug Design; Enzyme Inhibitors; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Osteoarthritis; Phosphoric Diester Hydrolases; Piperidines; Protein Binding; Pyrophosphatases; Quinazolines; Sulfonamides | 2009 |
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Humans; Hydroxamic Acids; Mice; Piperidines; Protease Inhibitors; Sulfones | 2009 |
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.
Topics: Amantadine; Animals; Antiviral Agents; Humans; Imidazoles; Influenza A virus; Oocytes; Piperidines; Protein Conformation; Spiro Compounds; Structure-Activity Relationship; Viral Matrix Proteins; Xenopus | 2009 |
Synthesis and anti-inflammatory activity of novel (4-hydroxyphenyl)(2,4-dimethoxyphenyl) methanone derivatives.
Topics: Animals; Anti-Inflammatory Agents; Benzophenones; Carrageenan; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Male; Molecular Structure; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 2009 |
Organocatalytic regio- and stereoselective inverse-electron-demand aza-Diels-Alder reaction of alpha,beta-unsaturated aldehydes and N-tosyl-1-aza-1,3-butadienes.
Topics: Aldehydes; Aza Compounds; Butadienes; Catalysis; Crystallography, X-Ray; Electrons; Molecular Conformation; Piperidines; Stereoisomerism | 2009 |
A concise approach to the core structures of pinnaic acid and halichlorine.
Topics: Alkaloids; Crystallography, X-Ray; Nitrogen Oxides; Oxidation-Reduction; Piperidines; Quinazolines; Spiro Compounds; Stereoisomerism | 2009 |
Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate.
Topics: Aza Compounds; Molecular Structure; Piperidines; Spiro Compounds; Stereoisomerism | 2009 |
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Blood Pressure; Epoxide Hydrolases; Humans; Hypertension; Models, Molecular; Piperidines; Protein Binding; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Urea | 2009 |
The barrier to enantiomerization and dynamic resolution of N-Boc-2-lithiopiperidine and the effect of TMEDA.
Topics: Catalysis; Ethylenediamines; Kinetics; Piperidines; Stereoisomerism; Thermodynamics | 2009 |
Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.
Topics: Animals; Guinea Pigs; Molecular Structure; Piperidines; Protein Binding; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship | 2009 |
A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton.
Topics: Anti-Bacterial Agents; Biomimetics; Crystallography, X-Ray; Molecular Conformation; Piperidines; Thiostrepton | 2002 |
Total synthesis of alkaloid (+/-)-G. B. 13 using a Rh(I)-catalyzed ketone hydroarylation and late-stage pyridine reduction.
Topics: Alkaloids; Boron; Catalysis; Esters; Ketones; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Piperidines; Pyridines; Rhodium | 2009 |
Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones.
Topics: Amides; Anti-Infective Agents; Antifungal Agents; Bacteria; Benzofurans; Crystallography, X-Ray; Fungi; Humans; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Stereoisomerism | 2009 |
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
Topics: Animals; Fibrinolytic Agents; Glutamic Acid; Humans; Male; Piperidines; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Structure-Activity Relationship | 2009 |
Delta agonist hydroxy bioisosteres: the discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability.
Topics: Analgesics; Animals; Diphenylamine; Humans; Microsomes, Liver; Piperidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 2009 |
Alkaloids from Piper sarmentosum and Piper nigrum.
Topics: Alkaloids; Aporphines; Benzodioxoles; Cell Survival; Fatty Acids, Unsaturated; HeLa Cells; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Piper; Piper nigrum; Piperidines; Plant Roots; Polyunsaturated Alkamides | 2009 |
Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Cell Membrane; Dogs; Guinea Pigs; Humans; Inositol Phosphates; Isotope Labeling; Kinetics; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Piperidines; Protein Structure, Tertiary; Rats; Receptors, Neurokinin-3; Reproducibility of Results; Tritium | 2009 |
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.
Topics: Animals; Benzimidazoles; Cricetinae; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Receptors, Opioid; Structure-Activity Relationship | 2009 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding | 2009 |
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Topics: Administration, Oral; Animals; Binding Sites; Computer Simulation; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Microsomes, Liver; Piperidines; Rats; Urea | 2010 |
Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Imidazolidines; Microbial Sensitivity Tests; Piperidines; Thiohydantoins | 2010 |
One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents.
Topics: Antifungal Agents; Catalysis; Fluconazole; Miconazole; Microbial Sensitivity Tests; Piperidines; Structure-Activity Relationship; Triazines; Zirconium | 2010 |
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.
Topics: Animals; Calcium Channels; Cytochrome P-450 Enzyme System; Drug Inverse Agonism; Humans; Piperidines; Rats; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Sulfonamides; Sulfones | 2010 |
Piperidine-based heterocyclic oxalyl amides as potent p38 alpha MAP kinase inhibitors.
Topics: Amides; Crystallography, X-Ray; Heterocyclic Compounds; Humans; Mitogen-Activated Protein Kinase 14; Oxalates; Piperidines; Protein Kinase Inhibitors | 2010 |
Piperidine-derived gamma-secretase modulators.
Topics: Acetates; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cell Line, Tumor; Dogs; Humans; Mice; Peptide Fragments; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity | 2010 |
Highly specific dual enzyme-mediated payload release from peptide-coated silica particles.
Topics: Amines; Chromatography, High Pressure Liquid; Chymotrypsin; Dextrans; Hydrolysis; Peptides; Piperidines; Silicon Dioxide; Substrate Specificity; Thermolysin | 2010 |
Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation.
Topics: Analysis of Variance; Gas Chromatography-Mass Spectrometry; Gastric Acid; Gastric Mucosa; Linoleic Acid; Lipids; Morpholines; Nitrogen Compounds; Nitrosamines; Nitrosation; Piperidines; Water | 2010 |
Enantioselective construction of lactone[2,3-b]piperidine skeletons via organocatalytic tandem reactions.
Topics: Butadienes; Catalysis; Cyclization; Lactones; Molecular Structure; Oxygen; Piperidines; Stereoisomerism; Ytterbium | 2010 |
Quantitative analysis of penicillins in porcine tissues, milk and animal feed using derivatisation with piperidine and stable isotope dilution liquid chromatography tandem mass spectrometry.
Topics: Animal Feed; Animals; Chromatography, Liquid; Indicator Dilution Techniques; Kidney; Milk; Molecular Structure; Muscle, Skeletal; Penicillins; Piperidines; Protons; Swine; Tandem Mass Spectrometry | 2010 |
Synthesis of diphenylamine-based novel fluorescent styryl colorants by Knoevenagel condensation using a conventional method, biocatalyst, and deep eutectic solvent.
Topics: Biocatalysis; Coloring Agents; Diphenylamine; Ethanol; Fluorescence; Lipase; Molecular Structure; Piperidines; Solvents; Stereoisomerism; Styrenes | 2010 |
Formation of Pent-4-en-1-amine, the counterpart of acrylamide from lysine and its conversion into piperidine in lysine/glucose reaction mixtures.
Topics: Acrylamide; Chemical Phenomena; Glucose; Lysine; Piperidines | 2010 |
The application of a new piperdine derivative to spinal anesthesia; preliminary report.
Topics: Anesthesia, Spinal; Humans; Piperidines | 1947 |
The occurrence and determination of piperidine in human and animal urine.
Topics: Animals; Body Fluids; Humans; Piperidines; Urine | 1945 |
Piperidine derivatives; local anesthetics derived from substituted piperidinoalcohols.
Topics: Anesthesia, Local; Anesthetics, Local; Piperidines | 1946 |
4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: novel C7 moieties of fluoroquinolones as antibacterial agents.
Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Piperidines | 2010 |
Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.
Topics: Anti-Inflammatory Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship | 2010 |
Transition states and origins of 1,4-asymmetric induction in alkylations of 2,2,6-trialkylpiperidine enamines.
Topics: Aldehydes; Alkylation; Molecular Conformation; Piperidines | 2010 |
Conformational analysis of piperazine and piperidine analogs of GBR 12909: stochastic approach to evaluating the effects of force fields and solvent.
Topics: Models, Chemical; Piperazine; Piperazines; Piperidines; Solvents | 2011 |
Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs.
Topics: Animals; Biological Products; Electrophysiological Phenomena; Glutamic Acid; Heterocyclic Compounds; Mice; Neurons; Piperidines; Pyrrolidinones; Receptors, AMPA | 2010 |
Dual-acting drugs: an in vitro study of nonimidazole histamine H3 receptor antagonists combining anticholinesterase activity.
Topics: Animals; Cholinesterase Inhibitors; Guinea Pigs; Histamine H3 Antagonists; Humans; Piperidines; Rats; Receptors, Histamine H3; Structure-Activity Relationship | 2010 |
Synthesis of 5-azaindoles via a cycloaddition reaction between nitriles and donor-acceptor cyclopropanes.
Topics: Aza Compounds; Cyclopropanes; Indoles; Nitriles; Oxidation-Reduction; Piperidines; Pyridines | 2010 |
Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids.
Topics: Alkaloids; Biological Products; Hydroxylation; Nitrogen Oxides; Piperidines; Pyrrolidines; Small Molecule Libraries; Solutions; Volatilization | 2011 |
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
Topics: Animals; Azetidines; Calcium Channel Blockers; Calcium Channels, T-Type; Drug Design; Humans; Pain; Piperidines; Protein Binding; Rats; Spiro Compounds; Structure-Activity Relationship | 2010 |
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Topics: Administration, Oral; Animals; Brain; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; Molecular Conformation; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 4; Spiro Compounds; Structure-Activity Relationship | 2010 |
Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima.
Topics: Alkaloids; Animals; Caribbean Region; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Mycobacterium tuberculosis; Oceans and Seas; Piperidines; Plasmodium falciparum; Porifera | 2010 |
CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.
Topics: Biomimetic Materials; CD4 Antigens; Cell Line; HIV Envelope Protein gp120; HIV Fusion Inhibitors; Humans; Piperidines; Protein Binding; Receptors, CXCR4; Structure-Activity Relationship | 2010 |
Highly enantioselective catalytic dynamic resolution of N-Boc-2-lithiopiperidine: synthesis of (R)-(+)-N-Boc-pipecolic acid, (S)-(-)-coniine, (S)-(+)-pelletierine, (+)-beta-conhydrine, and (S)-(-)-ropivacaine and formal synthesis of (-)-lasubine II and (+
Topics: Alkaloids; Amides; Catalysis; Heterocyclic Compounds, 2-Ring; Lithium; Molecular Conformation; Organometallic Compounds; Pipecolic Acids; Piperidines; Quinolizines; Ropivacaine; Stereoisomerism; Thermodynamics | 2010 |
One-pot formation of piperidine- and pyrrolidine-substituted pyridinium salts via addition of 5-alkylaminopenta-2,4-dienals to N-acyliminium ions: application to the synthesis of (±)-nicotine and analogs.
Topics: Acrylates; Alkylation; Amines; Imines; Ions; Molecular Structure; Nicotine; Piperidines; Pyridinium Compounds; Pyrrolidines | 2010 |
Domino imino-aldol-aza-Michael reaction: one-pot diastereo- and enantioselective synthesis of piperidines.
Topics: Imines; Piperidines; Stereoisomerism; Substrate Specificity | 2010 |
Stereoselective synthesis of 2,4,5-trisubstituted piperidines via radical cyclization.
Topics: Bromine; Cyclization; Piperidines; Stereoisomerism; Substrate Specificity | 2010 |
A modular, efficient, and stereoselective synthesis of substituted piperidin-4-ols.
Topics: Catalysis; Gold; Molecular Structure; Piperidines; Stereoisomerism | 2010 |
Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists.
Topics: Animals; Binding Sites; Brain; Dioxolanes; Models, Theoretical; Piperidines; Receptors, N-Methyl-D-Aspartate; Static Electricity; Stereoisomerism; Structure-Activity Relationship; Swine | 2010 |
Intramolecular reductive cyclization strategy to the synthesis of (-)-6-methyl-3-hydroxy-piperidine-2-carboxylic acid, (+)-6-methyl-(2-hydroxymethyl)-piperidine-3-ol and their glycosidase inhibitory activity.
Topics: Cyclization; Enzyme Inhibitors; Geobacillus; Glycoside Hydrolases; Oxidation-Reduction; Pipecolic Acids; Piperidines; Saccharomyces cerevisiae; Stereoisomerism | 2010 |
Total synthesis of quinolizidine (-)-217A.
Topics: Aldehydes; Molecular Structure; Piperidines; Quinolizines; Stereoisomerism | 2010 |
p-Aminobenzoates of piperidino- and morpholinomethylnaphthols.
Topics: 4-Aminobenzoic Acid; Acids; Morpholines; para-Aminobenzoates; Piperidines | 1946 |
Piperidine derivatives; the preparation of l-benzoyl-3-carbethoxy-4-piperidone; a synthesis of guvacine.
Topics: Nicotinic Acids; Piperidines; Piperidones | 1946 |
Piperidine derivatives; C-alkylation of l-benzoyl-3-carbethoxy-4-piperidone; synthesis of ethyl 3-ethyl-4-piperidylacetate (d1-ethyl cincholoiponate).
Topics: Alkylation; Piperidines; Piperidones | 1946 |
Influence of 933F on dog hypertension in chronic renal ischemia.
Topics: Blood Pressure; Blood Pressure Determination; Hypertension; Piperidines | 1945 |
Report relating to the inclusion in Table A of the ethyl ester of l-methyl-4-phenylpiperine-4-carbonic acid (dolosal) and its salts.
Topics: Meperidine; Piperidines | 1945 |
Comparative action on the diuresis of morphine hydrochloride and hydrochloride of ethyl ester of l-methyl-4-phenyl-piperidine-carbonic acid (dolosal).
Topics: Diuresis; Humans; Meperidine; Morphine; Piperidines | 1945 |
Experiments in the piperidine series.
Topics: Humans; Piperidines | 1946 |
The beta-hydroxy and beta-halo ethyl 3- and 4-nitro phthalimides.
Topics: Humans; Lewy Bodies; Phthalimides; Piperidines | 1946 |
The antispasmodic activity of substituted phenyl propyl piperidines.
Topics: Parasympatholytics; Piperidines; Spasm | 1946 |
The interaction between neostigmine and epinephrine and the dimethylpiperidines.
Topics: Adrenal Glands; Epinephrine; Neostigmine; Piperidines; Tissue Extracts | 1946 |
4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
Topics: Allosteric Regulation; Amides; Humans; Microsomes, Liver; Piperazine; Piperazines; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Schizophrenia; Structure-Activity Relationship | 2010 |
Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine.
Topics: Animals; Benzofurans; Female; Humans; Ligands; Male; Mice; Molecular Imaging; Piperidines; Radioactive Tracers; Rats; Receptors, sigma; Sigma-1 Receptor; Steroid Isomerases; Substrate Specificity | 2011 |
Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE).
Topics: Acetylcholinesterase; Binding Sites; Cholinesterase Inhibitors; Drug Design; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Piperidines; Quantitative Structure-Activity Relationship | 2011 |
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.
Topics: Amides; Esters; Humans; Indoles; Ligands; Oxazines; Piperidines; Prodrugs; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists; Structure-Activity Relationship | 2010 |
Mechanism of the organocatalyzed decarboxylative Knoevenagel-Doebner reaction. A theoretical study.
Topics: Benzaldehydes; Beverages; Carboxylic Acids; Catalysis; Food; Malonates; Models, Molecular; Molecular Conformation; Phenols; Piperidines; Proline; Quantum Theory; Solvents | 2010 |
Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.
Topics: Autophagy; Cell Line, Tumor; Humans; Piperidines; Structure-Activity Relationship | 2011 |
Energy-dependent collision-induced dissociation study of buprenorphine and its synthetic precursors.
Topics: Buprenorphine; Chemistry, Pharmaceutical; Piperidines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
Structure-reactivity relationship of piperidine nitroxide: electrochemical, ESR and computational studies.
Topics: Ascorbic Acid; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Magnetic Resonance Spectroscopy; Piperidines; Structure-Activity Relationship | 2011 |
Binary matrix for MALDI imaging mass spectrometry of phospholipids in both ion modes.
Topics: Animals; Brain; Coumaric Acids; Gentisates; Ionic Liquids; Molecular Imaging; Phospholipids; Piperidines; Principal Component Analysis; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Trifluoroacetic Acid | 2011 |
A practical synthesis of renin inhibitor MK-1597 (ACT-178882) via catalytic enantioselective hydrogenation and epimerization of piperidine intermediate.
Topics: Catalysis; Cresols; Cyclopropanes; Enzyme Inhibitors; Hydrogenation; Hypertension; Molecular Structure; Piperidines; Pyridines; Renin; Stereoisomerism | 2011 |
Well-defined N-heterocyclic carbene silver halides of 1-cyclohexyl-3-arylmethylimidazolylidenes: synthesis, structure and catalysis in A3-reaction of aldehydes, amines and alkynes.
Topics: Acetylene; Aldehydes; Alkynes; Amines; Bromides; Catalysis; Crystallography, X-Ray; Heterocyclic Compounds; Hydrogen Bonding; Ligands; Methane; Molecular Structure; Piperidines; Silver Compounds; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction | 2011 |
Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors.
Topics: Animals; Dopamine; Humans; Models, Molecular; Neurotransmitter Agents; Norepinephrine; Piperidines; Protein Binding; Rabbits; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2011 |
II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.
Topics: Humans; Inhibitory Concentration 50; Molecular Structure; Piperazine; Piperazines; Piperidines; Pyridines; Receptors, CXCR3; Structure-Activity Relationship | 2011 |
Anthraquinone-sensitized photooxidation of 5-methylcytosine in DNA leading to piperidine-induced efficient strand cleavage.
Topics: Anthraquinones; Deoxycytidine; DNA; DNA Cleavage; DNA Methylation; Electrons; Molecular Structure; Oxidation-Reduction; Photochemistry; Piperidines; Solutions; Water | 2011 |
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.
Topics: Aniline Compounds; HEK293 Cells; Hep G2 Cells; Humans; Methylamines; Nitrobenzoates; Nuclear Receptor Coactivator 2; Piperidines; Protein Binding; Receptors, Thyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship | 2011 |
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Topics: Acetyl-CoA Carboxylase; Administration, Oral; Animals; Fluorine; Formic Acid Esters; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship | 2011 |
Acid- and base-catalysis in the mononuclear rearrangement of some (Z)-arylhydrazones of 5-amino-3-benzoyl-1,2,4-oxadiazole in toluene: effect of substituents on the course of reaction.
Topics: Alkalies; Amines; Biological Products; Catalysis; Dioxanes; Hydrazones; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Structure; Oxadiazoles; Piperidines; Structure-Activity Relationship; Temperature; Toluene; Trichloroacetic Acid; Urea; Water | 2011 |
Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)].
Topics: 1-Octanol; Binding Sites; Cell Line, Tumor; Cisplatin; Cross-Linking Reagents; DNA; DNA Adducts; Ethidium; Humans; Ligands; Light; Organoplatinum Compounds; Piperidines; Pyridines | 2011 |
A ¹⁸F-labeled fluorobutyl-substituted spirocyclic piperidine derivative as a selective radioligand for PET Imaging of sigma₁ receptors.
Topics: Animals; Autoradiography; Brain; Female; Fluorine Radioisotopes; Haloperidol; Isotope Labeling; Mice; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, sigma; Spiro Compounds; Tissue Distribution | 2011 |
Scaffolding catalysts: highly enantioselective desymmetrization reactions.
Topics: Alcohols; Catalysis; Crystallography, X-Ray; Molecular Conformation; Piperidines; Silanes; Stereoisomerism | 2011 |
Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Biological Transport; Cell Membrane Permeability; Dose-Response Relationship, Drug; Mice; Mice, Knockout; Molecular Structure; Piperidines; Rats; Renin; Stereoisomerism; Structure-Activity Relationship | 2011 |
Access to optically active 3-azido- and 3-aminopiperidine derivatives by enantioselective ring expansion of prolinols.
Topics: Amines; Azides; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Piperidines; Pyrrolidines; Stereoisomerism | 2011 |
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Topics: Animals; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Orexin Receptors; Piperidines; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep Wake Disorders; Stereoisomerism; Structure-Activity Relationship | 2011 |
A convenient route to optically pure α-alkyl-β-(sec-amino)alanines.
Topics: Alanine; Cyclization; Lactones; Morpholines; Piperidines; Pyrrolidines; Serine; Stereoisomerism | 2012 |
Radical polymer-wrapped SWNTs at a molecular level: high-rate redox mediation through a percolation network for a transparent charge-storage material.
Topics: Crystallography, X-Ray; Electric Conductivity; Electric Power Supplies; Electrochemical Techniques; Electrodes; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanocomposites; Nanotubes, Carbon; Oxidation-Reduction; Piperidines; Polymethacrylic Acids | 2011 |
Regio- and enantioselective hydroamination of dienes by gold(I)/menthol cooperative catalysis.
Topics: Alkadienes; Amination; Catalysis; Gold; Menthol; Molecular Structure; Piperidines; Pyrrolidines; Stereoisomerism | 2011 |
Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
Topics: Binding Sites; Caspase 2; Caspase 3; Caspase Inhibitors; Catalytic Domain; Cell Line; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoquinolines; Molecular Dynamics Simulation; Piperidines; Proline; Substrate Specificity | 2011 |
Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists.
Topics: Drug Discovery; Ligands; Orexin Receptors; Piperidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide | 2011 |
Vapor treatment of electrospray droplets: evidence for the folding of initially denatured proteins on the sub-millisecond time-scale.
Topics: Acetic Acid; Animals; Cattle; Gases; Humans; Hydrogen-Ion Concentration; Piperidines; Protein Conformation; Protein Denaturation; Protein Refolding; Proteins; Spectrometry, Mass, Electrospray Ionization; Static Electricity | 2012 |
Synthesis and pharmacological evaluation of 1-alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line; Guinea Pigs; Humans; Hypertension; Male; Piperidines; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 2011 |
Straightforward access to enantioenriched 2-allylpiperidine: application to the synthesis of alkaloids.
Topics: Alkaloids; Molecular Structure; Piperidines; Stereoisomerism | 2012 |
Novel brain penetrant benzofuropiperidine 5-HT₆ receptor antagonists.
Topics: Animals; Benzofurans; Brain; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Inhibitory Concentration 50; Kinetics; Memory, Short-Term; Models, Chemical; Piperidines; Rats; Receptors, Serotonin; Schizophrenia; Serotonin Antagonists; Structure-Activity Relationship | 2012 |
Synthesis and antileukemic activity of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)ethanone derivatives.
Topics: Antineoplastic Agents; Benzophenones; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Leukemia; Piperidines | 2012 |
Excretion, metabolism, and pharmacokinetics of 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide, a selective cannabinoid receptor antagonist, in healthy male volunteers.
Topics: Adult; Amides; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Feces; Humans; Hydrolysis; Hydroxylation; Male; Microsomes, Liver; Middle Aged; Oximes; Piperidines; Purines; Receptor, Cannabinoid, CB1; Young Adult | 2012 |
Enantioselective synthesis of pyrrolidine-, piperidine-, and azepane-type N-heterocycles with α-alkenyl substitution: the CpRu-catalyzed dehydrative intramolecular N-allylation approach.
Topics: Azepines; Catalysis; Molecular Structure; Piperidines; Pyrrolidines; Ruthenium Compounds; Stereoisomerism | 2012 |
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
Topics: Acetyl-CoA Carboxylase; Alkenes; Alkylation; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Indazoles; Ketones; Piperidines; Pyrazoles; Stereoisomerism; Substrate Specificity | 2012 |
Antimicrobial activity and SAR study of some novel thiosemicarbazide derivatives bearing piperidine moiety.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Dose-Response Relationship, Drug; Fungi; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidines; Semicarbazides; Structure-Activity Relationship | 2011 |
One-pot synthesis of a piperidine-based rigidified DTPA analogue and its bifunctional chelating agent.
Topics: Alkylation; Chelating Agents; Ligands; Molecular Structure; Pentetic Acid; Piperidines | 2012 |
Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4'-piperidine]-2-ones as potential c-Met inhibitors.
Topics: Binding Sites; Blotting, Western; Cell Proliferation; Drug Design; Drug Discovery; Fluorescence Resonance Energy Transfer; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Stomach Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2012 |
A piperidine chiron for the Veratrum alkaloids.
Topics: Caprylates; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidines; Stereoisomerism; Sulfonamides; Veratrum Alkaloids | 2012 |
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Cell Line; Chemistry Techniques, Synthetic; HIV Reverse Transcriptase; HIV-1; Inhibitory Concentration 50; Piperidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines | 2012 |
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
Topics: Amides; Animals; Cells, Cultured; Disease Models, Animal; Drug Discovery; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Obese; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Structure-Activity Relationship; Weight Loss | 2012 |
Synthesis of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine derivatives as potent antimicrobial agent.
Topics: Anthelmintics; Anti-Infective Agents; Antifungal Agents; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Structure-Activity Relationship | 2013 |
The sigma-1 receptor antagonist PB212 reduces the Ca²⁺-release through the inositol (1, 4, 5)-trisphosphate receptor in SK-N-SH cells.
Topics: Calcium; Calcium Signaling; Cell Line, Tumor; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Space; Ligands; Naphthalenes; Piperidines; Receptors, sigma; Sigma-1 Receptor; Substrate Specificity | 2012 |
Synthesis and biological evaluation of triazole derivatives as potential antifungal agent.
Topics: Antifungal Agents; Catalytic Domain; Fungi; Humans; Microbial Sensitivity Tests; Models, Molecular; Mycoses; Piperidines; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles | 2012 |
Synthesis and in vitro characterization of trans- and cis-[(18)F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-D-aspartate receptor.
Topics: Animals; Carboxylic Acids; Chemistry Techniques, Synthetic; Male; Piperidines; Positron-Emission Tomography; Radioactive Tracers; Radiochemistry; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 2012 |
Fmoc-Cl fluorescent determination for amino groups of nanomaterial science.
Topics: Amines; Fluorenes; Fluorescence; Kinetics; Nanoparticles; Piperidines; Silicon Dioxide; Spectrometry, Fluorescence | 2012 |
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles.
Topics: Anti-Bacterial Agents; Chemistry Techniques, Synthetic; Drug Discovery; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitriles; Oxadiazoles; Oxides; Piperidines; Pyrans; Stereoisomerism | 2012 |
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.
Topics: Amines; Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines | 2012 |
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Topics: Animals; Azetidines; Drug Inverse Agonism; Humans; Microsomes, Liver; Piperidines; Rats; Receptors, Ghrelin; Structure-Activity Relationship | 2012 |
Effects of piperidine and piperideine alkaloids from the venom of red imported fire ants, Solenopsis invicta Buren, on Pythium ultimum Trow growth in vitro and the application of piperideine alkaloids to control cucumber damping-off in the greenhouse.
Topics: Alkaloids; Animals; Ant Venoms; Cucumis sativus; Mycelium; Pest Control; Piperidines; Pythium; Temperature | 2012 |
Preparation and spectral characterization of fluorescence probes based on 4-N,N-dimethylamino benzoic acid and sterically hindered amines.
Topics: Amides; Amines; Fluorescent Dyes; para-Aminobenzoates; Piperidines; Spectrometry, Fluorescence | 2012 |
Coupling technique of self-ordered ring and phosphorimetry for the determination of alkaline phosphatase and diseases prediction.
Topics: Alkaline Phosphatase; Anthraquinones; Buffers; Disease; Humans; Limit of Detection; Luminescent Measurements; Piperidines; Rhodamines; Solvents; Substrate Specificity; Temperature; Wheat Germ Agglutinins | 2012 |
α-Geminal dihydroxymethyl piperidine and pyrrolidine iminosugars: synthesis, conformational analysis, glycosidase inhibitory activity, and molecular docking studies.
Topics: Enzyme Inhibitors; Glycoside Hydrolases; Imino Sugars; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Pyrrolidines | 2012 |
Synthesis and evaluation of a series of piperidine-2,6-dione-piperazine (piperidine) derivatives as multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Mice; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Serotonin; Structure-Activity Relationship | 2012 |
Total synthesis of (-)-kopsinine by an asymmetric one-pot [n+2+3] cyclization.
Topics: Alkylation; Amides; Cyclization; Indole Alkaloids; Lithium; Piperidines; Stereoisomerism | 2012 |
Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.
Topics: Aniline Compounds; Catalysis; Indoles; Lactams; Molecular Structure; Oxindoles; Piperidines; Pyrrolidines; Spiro Compounds; Stereoisomerism | 2012 |
Peptidomimetics as potent and selective PTP1B inhibitors.
Topics: Acetates; Amides; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Peptidomimetics; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Structure-Activity Relationship; Substrate Specificity | 2013 |
The discovery of CCR3/H1 dual antagonists with reduced hERG risk.
Topics: Animals; Drug Discovery; Drug Interactions; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Molecular Structure; Piperidines; Rats; Receptors, CCR3; Risk Factors | 2012 |
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.
Topics: Animals; Calcium; Cells, Cultured; Chemotaxis; Humans; Mice; Microsomes, Liver; Monocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Rabbits; Rats; Receptors, CCR; Structure-Activity Relationship; Tissue Distribution | 2012 |
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues.
Topics: Amides; Animals; Anti-Bacterial Agents; Antidepressive Agents; Antifungal Agents; Antioxidants; Behavior, Animal; Candida albicans; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperazine; Piperazines; Piperidines | 2012 |
Rigid Mn(II) chelate as efficient MRI contrast agent for vascular imaging.
Topics: Chelating Agents; Contrast Media; Coordination Complexes; Crown Compounds; Crystallography, X-Ray; Humans; Magnetic Resonance Imaging; Manganese; Molecular Conformation; Piperidines; Pyridines; Veins | 2012 |
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Topics: Carbamates; Humans; Piperidines; Protein Binding; Pyrazoles; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2013 |
Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin; Cyclin D1; Cyclohexanones; Down-Regulation; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; NF-kappa B; Piperidines; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-met; Reactive Oxygen Species; Repressor Proteins; Sp Transcription Factors | 2012 |
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Topics: Anti-Inflammatory Agents; Catalytic Domain; Epoxide Hydrolases; Humans; Inhibitory Concentration 50; Microsomes, Liver; Models, Molecular; Molecular Structure; Piperidines; Protease Inhibitors; Solubility; Structure-Activity Relationship; Urea; Vasodilator Agents | 2013 |
Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; K562 Cells; Molecular Structure; Oxidative Stress; Piperidines; Structure-Activity Relationship; Sulfonamides | 2013 |
Enaminonitriles in heterocyclic synthesis: a route to 1,3-diaryl-4-aminopyrazole derivatives.
Topics: Acrylonitrile; Alkylation; Cyclization; Diazonium Compounds; Dimethylformamide; Formates; Heterocyclic Compounds, 2-Ring; Microwaves; Nitriles; Piperidines; Pyrazoles; Solvents | 2013 |
Structure of a piperidine-modified calix[4]arene derivative and spectral resolution of its interaction with rare earth metals with chemometric methods.
Topics: Calixarenes; Coordination Complexes; Crystallography, X-Ray; Furans; Metals, Rare Earth; Models, Molecular; Phenols; Piperidines; Spectrophotometry, Ultraviolet | 2013 |
Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites.
Topics: Animals; Hepatocytes; Nitrogen; Piperidines; Plasmodium; Protozoan Proteins; Pyrroles; Sporozoites | 2013 |
Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Piperidines; Quinolones; Structure-Activity Relationship | 2013 |
Spirocyclic compounds, potent CCR1 antagonists.
Topics: Animals; Caco-2 Cells; Cell Line; Chemotaxis; Humans; Microsomes, Liver; Piperidines; Protein Binding; Rats; Receptors, CCR1; Spiro Compounds | 2013 |
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.
Topics: Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hydrogen-Ion Concentration; Piperidines; Protein Binding; Pyrrolidines; Structure-Activity Relationship; Temperature | 2013 |
Interaction of piperidin derivative of Mannich base with DPPC liposomes.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Calorimetry, Differential Scanning; Liposomes; Mannich Bases; Phase Transition; Piperidines; Spectrometry, Fluorescence | 2013 |
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
Topics: Anti-HIV Agents; Cell Line; Drug Discovery; HIV Integrase; HIV-1; Humans; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Models, Molecular; Oxyquinoline; Piperazine; Piperazines; Piperidines; Protein Binding; Protein Conformation; Structure-Activity Relationship | 2013 |
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding, Competitive; Biocatalysis; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyridazines; Structure-Activity Relationship | 2013 |
Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Amides; Animals; Binding Sites; Drug Design; Enzyme Inhibitors; Half-Life; Humans; Isomerism; Mice; Molecular Docking Simulation; Piperidines; Protein Structure, Tertiary; Structure-Activity Relationship | 2013 |
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
Topics: Animals; Benzodioxoles; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Monoacylglycerol Lipases; Piperazine; Piperazines; Piperidines; Rats; Substrate Specificity; Triazoles; Urea | 2013 |
Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.
Topics: Binding Sites; Drug Design; HCT116 Cells; Humans; Imidazolines; Molecular Docking Simulation; Piperidines; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-mdm2; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2013 |
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Topics: Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Cyclization; Dose-Response Relationship, Drug; Indoles; Models, Molecular; Molecular Structure; Oxindoles; Piperidines; Pyrroles; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship | 2013 |
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.
Topics: Drug Design; Nociceptin Receptor; Piperidines; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 2013 |
An expedient synthesis and screening for antiacetylcholinesterase activity of piperidine embedded novel pentacyclic cage compounds.
Topics: Acetylcholinesterase; Aza Compounds; Cholinesterase Inhibitors; Cyclopentanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship | 2014 |
Complex N-heterocycle synthesis via iron-catalyzed, direct C-H bond amination.
Topics: Amination; Amines; Azetidines; Azides; Catalysis; Chemical Phenomena; Cyclization; Heterocyclic Compounds; Iron; Ligands; Molecular Structure; Piperidines; Pyrrolidines | 2013 |
Discovery of piperidine-linked pyridine analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Discovery; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Piperidines; Pyridines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2013 |
Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands.
Topics: Animals; Binding Sites; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Guinea Pigs; Ligands; Male; Molecular Conformation; Piperazine; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Structure-Activity Relationship | 2013 |
The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine.
Topics: Alkenes; Free Radicals; Imines; Paroxetine; Photolysis; Piperidines; Quantum Theory; Selective Serotonin Reuptake Inhibitors; Thermodynamics; Water | 2013 |
Antitumor activity and DNA-binding investigations of isoeuxanthone and its piperidinyl derivative.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Survival; Circular Dichroism; DNA; HeLa Cells; Hep G2 Cells; Humans; Piperidines; Spectrophotometry, Ultraviolet; Xanthones | 2013 |
Structural equilibrium in new nitroxide-capped cyclodextrins: CW and pulse EPR study.
Topics: Cyclodextrins; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Kinetics; Nitrogen Oxides; Piperidines; Pyrroles; Pyrrolidines; Spin Labels | 2013 |
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds.
Topics: Animals; Male; Mice; Mice, Inbred ICR; Models, Molecular; Neurotransmitter Uptake Inhibitors; Piperidines; Prefrontal Cortex; Structure-Activity Relationship | 2013 |
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Topics: Administration, Oral; Amides; Animals; Blood Pressure; Disease Models, Animal; Furosemide; Half-Life; Hypertension; Macaca fascicularis; Piperazines; Piperidines; Protease Inhibitors; Rats; Rats, Transgenic; Renin; Structure-Activity Relationship | 2013 |
Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Humans; Hydrogen Peroxide; Lycopodiaceae; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; Piperidines | 2013 |
Structure-activity relationships of new 1-substitutedmethyl-4-[5-(N-methyl-N-propylamino)pentyloxy]piperidines and selected 1-[(N-substituted-N-methyl)-3-propyloxy]-5-(N-methy-l-N-propyl)-pentanediamines as H3 -antagonists.
Topics: Amines; Animals; Guinea Pigs; Histamine Antagonists; Jejunum; Male; Muscle Contraction; Piperidines; Receptors, Histamine H3; ROC Curve; Structure-Activity Relationship | 2014 |
Α,β-unsaturated diazoketones as versatile building blocks for the synthesis of hydroxylated piperidines, indolizidines and quinolizidines.
Topics: Diazonium Compounds; Indolizidines; Molecular Structure; Piperidines; Quinolizidines; Stereoisomerism | 2013 |
Applications and limitations of the I2-mediated carbamate annulation for the synthesis of piperidines: five- versus six-membered ring formation.
Topics: 1-Deoxynojirimycin; Carbamates; Cyclization; Fucose; Imino Pyranoses; Molecular Structure; Piperidines; Stereoisomerism | 2013 |
Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.
Topics: Administration, Oral; Amides; Analgesics; Animals; Disease Models, Animal; Half-Life; Male; Mice; Mice, Inbred C57BL; Neuralgia; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; TRPM Cation Channels | 2013 |
A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Computer Simulation; Hippocampus; Microsomes; Piperidines; Positron-Emission Tomography; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Reflex; Superior Colliculi; Time Factors; Urinary Bladder, Overactive; Urination | 2013 |
Design of fluorinated 5-HT(4)R antagonists: influence of the basicity and lipophilicity toward the 5-HT(4)R binding affinities.
Topics: Animals; Drug Design; Guinea Pigs; Halogenation; Humans; Piperidines; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists | 2013 |
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Topics: Administration, Oral; Animals; Body Weight; Diet; Enzyme Activation; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Protein Binding; Rats; Stearoyl-CoA Desaturase; Structure-Activity Relationship; Urea | 2013 |
Hg2+ wettability and fluorescence dual-signal responsive switch based on a cysteine complex of piperidine-calix[4]arene.
Topics: Calixarenes; Click Chemistry; Cysteine; Fluorescence; Magnetic Resonance Spectroscopy; Mercury; Models, Molecular; Molecular Structure; Particle Size; Phenols; Piperidines; Protons; Silicon; Surface Properties; Wettability | 2013 |
Spectrophotometric and thermal studies on the charge--transfer complexes of 4-(aminomethyl) piperidine as donor with σ- and π-electron acceptors.
Topics: Amines; Benzoquinones; Cyclohexenes; Electrons; Iodine; Methylation; Nitriles; Piperidines; Spectrophotometry; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2014 |
O(2)-dependent efficacy of novel piperidine- and piperazine-based chalcones against the human parasite Giardia intestinalis.
Topics: Antiprotozoal Agents; Caco-2 Cells; Cell Survival; Chalcones; Giardia lamblia; Humans; Piperazine; Piperazines; Piperidines | 2014 |
Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds.
Topics: Adenosine Diphosphate; Amines; Animals; Blood Platelets; Half-Life; Humans; Microsomes, Liver; Piperidines; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Agonists; Rats; Receptors, Purinergic P2Y1; Structure-Activity Relationship; Urea | 2013 |
Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.
Topics: Aniline Compounds; Anti-HIV Agents; Drug Design; HIV-1; Humans; Models, Molecular; Piperidines; Structure-Activity Relationship | 2014 |
Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis.
Topics: Amino Acid Sequence; Amino Acids; Dimethylformamide; Fluorenes; Microwaves; Organophosphorus Compounds; Peptides; Piperidines; Solid-Phase Synthesis Techniques; Solvents; Stereoisomerism; Triazoles | 2014 |
Pd-N-heterocyclic carbene catalyzed synthesis of piperidine alkene-alkaloids and their anti-cancer evaluation.
Topics: Alkaloids; Alkenes; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; MCF-7 Cells; Methane; Molecular Conformation; Organometallic Compounds; Palladium; Piperidines; Structure-Activity Relationship | 2014 |
Bicyclic hybrid sugars as glycosidase inhibitors: synthesis and comparative study of inhibitory activities of fused oxa-oxa, oxa-aza, and oxa-carbasugar hybrid molecules.
Topics: Aza Compounds; Carbasugars; Enzyme Inhibitors; Glycoside Hydrolases; Oxides; Piperidines; Pyrans | 2014 |
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.
Topics: Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Glycine Plasma Membrane Transport Proteins; Humans; Molecular Structure; Piperidines; Structure-Activity Relationship | 2014 |
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres.
Topics: Dose-Response Relationship, Drug; Glycine Plasma Membrane Transport Proteins; Humans; Molecular Structure; Piperidines; Structure-Activity Relationship; Sulfonamides | 2014 |
Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; Neuralgia; Piperidines; Pyridines; Rats | 2014 |
A multifaceted secondary structure mimic based on piperidine-piperidinones.
Topics: Amino Acids; Models, Molecular; Molecular Conformation; Piperidines; Protein Binding; Protein Structure, Secondary | 2014 |
Hydrogen-bonded chains in three cis-dichloridoplatinum(II) complexes bearing piperidine and amine ligands.
Topics: Amines; Crystallography, X-Ray; Hydrogen Bonding; Ligands; Organoplatinum Compounds; Piperidines | 2014 |
Regio- and stereoselective 1,2-dihydropyridine alkylation/addition sequence for the synthesis of piperidines with quaternary centers.
Topics: Alkylation; Catalysis; Dihydropyridines; Molecular Structure; Piperidines; Stereoisomerism | 2014 |
Regioselective piperidine-catalyzed tandem imination-isocyanate annulation to fused tricyclic triazines.
Topics: Benzimidazoles; Catalysis; Imines; Ionic Liquids; Isocyanates; Microwaves; Models, Molecular; Piperidines; Triazines | 2014 |
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Topics: Analgesics; Animals; Ligands; Mice; Models, Animal; Nociceptin Receptor; Pain; Piperidines; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 2014 |
New pyrano[2,3-c]pyridazine derivatives with antimicrobial activity synthesized using piperidine as the organocatalyst.
Topics: Anti-Bacterial Agents; Antifungal Agents; Aspergillus; Candida albicans; Catalysis; Chloramphenicol; Enterococcus faecalis; Escherichia coli; Klebsiella pneumoniae; Microbial Sensitivity Tests; Nystatin; Piperidines; Pyridazines; Pyrimidines; Staphylococcus aureus; Structure-Activity Relationship; Tetrazoles; Thiazines | 2015 |
Asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2 carboxylates.
Topics: Amino Acids; Catalysis; Chemistry, Organic; Circular Dichroism; Imines; Indole Alkaloids; Phosphoric Acids; Piperidines; Thiourea | 2014 |
Synthesis and characterization of [N-methyl-3H]loperamide.
Topics: Chemistry Techniques, Synthetic; Loperamide; Piperidines; Radiochemistry; Tritium | 2014 |
A new 3,5-bisporphyrinylpyridine derivative as a fluorescent ratiometric probe for zinc ions.
Topics: Crystallography, X-Ray; Fluorescent Dyes; Gases; Ions; Molecular Conformation; Piperidines; Polymethyl Methacrylate; Porphyrins; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Zinc | 2014 |
Combined effect of elevated UVB, elevated temperature and fertilization on growth, needle structure and phytochemistry of young Norway spruce (Picea abies) seedlings.
Topics: Abies; Alkaloids; Chromatography, High Pressure Liquid; Fertilizers; Finland; Gas Chromatography-Mass Spectrometry; Phenols; Piperidines; Plant Leaves; Temperature; Ultraviolet Rays | 2014 |
The dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Electrochemical Techniques; Gene Expression Regulation; Male; Motor Activity; Muscle Proteins; Piperidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Statistics as Topic | 2014 |
Synergistic cytotoxicity and DNA strand breaks in cells and plasmid DNA exposed to uranyl acetate and ultraviolet radiation.
Topics: Animals; Cell Line; Cell Survival; CHO Cells; Cocarcinogenesis; Cricetulus; DNA; DNA Adducts; DNA Breaks, Single-Stranded; DNA Repair; Hot Temperature; Humans; Indicators and Reagents; Keratinocytes; Mutagens; Organometallic Compounds; Photochemical Processes; Piperidines; Plasmids; Ultraviolet Rays | 2015 |
Directed functionalization of 1,2-dihydropyridines: stereoselective synthesis of 2,6-disubstituted piperidines.
Topics: Amidines; Dihydropyridines; Molecular Structure; Piperidines; Stereoisomerism | 2014 |
Quantitative analysis of alkaloidal constituents in imported fire ants by gas chromatography.
Topics: Alkaloids; Animals; Ants; Chromatography, Gas; Isomerism; Molecular Structure; Piperidines; Venoms | 2014 |
Catalytic asymmetric 1,3-dipolar [3 + 6] cycloaddition of azomethine ylides with 2-acyl cycloheptatrienes: efficient construction of bridged heterocycles bearing piperidine moiety.
Topics: Azo Compounds; Catalysis; Cyclization; Cycloheptanes; Heterocyclic Compounds; Molecular Conformation; Organometallic Compounds; Piperidines; Thiosemicarbazones | 2014 |
Fully diastereoselective synthesis of polysubstituted, functionalized piperidines and decahydroquinolines based on multicomponent reactions catalyzed by cerium(IV) ammonium nitrate.
Topics: Amines; Cerium; Molecular Structure; Nitrates; Piperidines; Stereoisomerism | 2014 |
Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Attention Deficit and Disruptive Behavior Disorders; Behavior, Animal; Disease Models, Animal; Female; HEK293 Cells; Humans; In Vitro Techniques; Male; Maze Learning; Membrane Potentials; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Piperidines; Synapses | 2014 |
Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Humans; Mice; Piperidines; Structure-Activity Relationship | 2014 |
Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates.
Topics: Biosensing Techniques; Cell Line, Tumor; Copper; Female; Fluorescent Dyes; Heterocyclic Compounds; Humans; Piperidines | 2014 |
Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.
Topics: Anti-HIV Agents; CD4 Antigens; Cell Line, Tumor; Crystallography, X-Ray; HeLa Cells; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Oxalates; Piperidines; Protein Binding | 2014 |
One-pot synthesis and antiproliferative activity of novel 2,4-diaminopyrimidine derivatives bearing piperidine and piperazine moieties.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Piperazine; Piperazines; Piperidines; Pyrimidines; Structure-Activity Relationship | 2014 |
Charge-transfer complexes of 4-methylpiperidine with σ- and π-acceptors.
Topics: Absorption, Physicochemical; Benzoquinones; Electrons; Nitriles; Piperidines; Solvents; Spectrophotometry, Infrared; Thermodynamics; Titrimetry | 2015 |
Extending the N-linked aminopiperidine class to the mycobacterial gyrase domain: pharmacophore mapping from known antibacterial leads.
Topics: Anti-Bacterial Agents; DNA Gyrase; Drug Design; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitrogen; Piperidines; Protein Structure, Tertiary; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2014 |
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
Topics: Allosteric Regulation; Animals; Central Nervous System; Drug Discovery; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Indazoles; Male; Piperidines; Rats; Receptor, Muscarinic M5; Substrate Specificity; Sulfonamides | 2014 |
Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
Topics: Biocatalysis; Carboxylic Acids; Carnitine; Catalytic Domain; gamma-Butyrobetaine Dioxygenase; Oxidation-Reduction; Piperidines; Stereoisomerism | 2014 |
Discovery and SAR study of piperidine-based derivatives as novel influenza virus inhibitors.
Topics: Animals; Antiviral Agents; Dogs; Drug Discovery; HEK293 Cells; HeLa Cells; Humans; Madin Darby Canine Kidney Cells; Microbial Sensitivity Tests; Molecular Structure; Orthomyxoviridae; Piperidines; Structure-Activity Relationship | 2014 |
Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
Topics: Animals; Atrophy; Chemistry Techniques, Synthetic; Drug Design; Ligands; Macular Degeneration; Male; Mice; Molecular Docking Simulation; Piperidines; Prealbumin; Protein Conformation; Rats; Retinol-Binding Proteins, Plasma; Stargardt Disease; Structure-Activity Relationship | 2014 |
Assessment of the effective absorbed dose of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine in humans on the basis of biodistribution data of rats.
Topics: Animals; Female; Humans; Piperidines; Radiation Dosage; Rats; Sulfonamides; Tissue Distribution | 2015 |
Inhibition of NarL of Mycobacterium Tuberculosis: an in silico approach.
Topics: Antitubercular Agents; Bacterial Proteins; Catalytic Domain; DNA-Binding Proteins; Formate Dehydrogenases; Humans; Molecular Docking Simulation; Mycobacterium tuberculosis; Nitrate Reductases; Nitrates; Nitrites; Nitrobenzenes; Nitrogen; Phosphorylation; Piperidines; Protein Kinases; Sequence Homology, Amino Acid; Signal Transduction; Transcription Factors; Tuberculosis | 2014 |
Novel N-amidinopiperidine-based proteasome inhibitor preserves dendritic cell functionality and rescues their Th1-polarizing capacity in Ramos-conditioned tumor environment.
Topics: Amidines; Antineoplastic Agents; Apoptosis; Blotting, Western; Burkitt Lymphoma; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Flow Cytometry; Humans; Lymphocyte Activation; Piperidines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Th1 Cells; Tumor Microenvironment | 2015 |
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Topics: Amides; Amidohydrolases; Carbamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Monoacylglycerol Lipases; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship | 2014 |
γ-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents.
Topics: Alkylation; alpha-Galactosidase; Binding Sites; Cell Proliferation; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Humans; Imino Sugars; Immunosuppressive Agents; Jurkat Cells; Leukocytes, Mononuclear; Molecular Docking Simulation; Piperidines; Protein Structure, Tertiary | 2014 |
Quenching of the perylene fluorophore by stable nitroxide radical-containing macromolecules.
Topics: Cyclic N-Oxides; Fluorescent Dyes; Molecular Conformation; Molecular Dynamics Simulation; Nitrogen Oxides; Perylene; Piperidines; Polymers; Spectrometry, Fluorescence | 2014 |
Anti-trypanosomal activities and structural chemical properties of selected compound classes.
Topics: Animals; Cell Line; Cysteine Proteases; Fumarates; Hydrogen-Ion Concentration; Macrophages; Mice; Mitochondria; Organelles; Piperazine; Piperazines; Piperidines; Trypanocidal Agents; Trypanosoma brucei brucei | 2015 |
Enantioselective oxidative gold catalysis enabled by a designed chiral P,N-bidentate ligand.
Topics: Catalysis; Crystallography, X-Ray; Cyclopropanes; Gold; Ligands; Methane; Molecular Conformation; Nitrogen; Oxidation-Reduction; Phosphorus; Piperidines; Stereoisomerism | 2015 |
The spectroscopic (FT-IR, FT-Raman, (l3)C, (1)H NMR and UV) and NBO analyses of 4-bromo-1-(ethoxycarbonyl)piperidine-4-carboxylic acid.
Topics: Carboxylic Acids; Halogenation; Magnetic Resonance Spectroscopy; Models, Molecular; Piperidines; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity | 2015 |
Design and synthesis of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents.
Topics: Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Humans; Hypoglycemic Agents; Molecular Docking Simulation; Molecular Structure; Piperidines; Pyrrolidines; Structure-Activity Relationship; Sulfonamides | 2015 |
Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker.
Topics: Acrolein; Amines; Cycloaddition Reaction; Imines; Norepinephrine; Oxidative Stress; Piperidines; Sphingosine | 2014 |
Design and synthesis of substituted morpholin/piperidin-1-yl-carbamodithioates as promising vaginal microbicides with spermicidal potential.
Topics: Antifungal Agents; Cell Survival; Drug Design; Female; HeLa Cells; Hexokinase; Humans; Lactobacillus; Male; Microbial Sensitivity Tests; Morpholines; Piperidines; Spermatocidal Agents; Spermatozoa; Structure-Activity Relationship; Sulfhydryl Compounds; Thiocarbamates; Trichomonas vaginalis | 2014 |
Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.
Topics: Animals; Benzimidazoles; Enzyme Inhibitors; HEK293 Cells; Humans; Kinetics; Microsomes; Phospholipase D; Piperidines; Protein Binding; Rats; Structure-Activity Relationship | 2014 |
Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model.
Topics: Animals; Humans; Indoles; Mice; Models, Molecular; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, CCR3; Species Specificity | 2015 |
Asymmetric tandem reactions of N-sulfonylimines and α,β-unsaturated aldehydes: an alternative reaction pathway to that of using saturated aldehydes.
Topics: Aldehydes; Catalysis; Imines; Models, Molecular; Molecular Conformation; Piperidines; Solvents; Sulfones | 2015 |
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
Topics: Animals; Diabetic Neuropathies; Half-Life; Humans; Ligands; Male; Microsomes, Liver; Pain; Pipecolic Acids; Piperidines; Protein Binding; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Solubility; Structure-Activity Relationship; Thiazines | 2015 |
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Ethers; Half-Life; Humans; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Protein Binding; Pyrimidines; Rats; Sleep; Structure-Activity Relationship | 2015 |
Importance of protein flexibility in ranking inhibitor affinities: modeling the binding mechanisms of piperidine carboxamides as Type I1/2 ALK inhibitors.
Topics: Amides; Anaplastic Lymphoma Kinase; Binding Sites; Entropy; Hydrophobic and Hydrophilic Interactions; Molecular Docking Simulation; Piperidines; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship | 2015 |
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.
Topics: Anaplastic Lymphoma Kinase; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Humans; Lymphoma, Large-Cell, Anaplastic; Mice, SCID; Models, Molecular; Piperidines; Protein Kinase Inhibitors; Pyrroles; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Triazines | 2015 |
Zincation of 4,4-dimethyloxazoline using TMPZnCl·LiCl. A new preparation of 2-aryloxazolines.
Topics: Catalysis; Organometallic Compounds; Oxazoles; Piperidines; Zinc | 2015 |
Synthesis of polyhydroxylated piperidine and pyrrolidine peptidomimetics via one-pot sequential lactam reduction/Joullié-Ugi reaction.
Topics: Carbohydrates; Lactams; Peptidomimetics; Piperidines; Pyrrolidines; Stereoisomerism | 2015 |
Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.
Topics: Animals; Benzamides; Half-Life; HEK293 Cells; Humans; Membrane Transport Proteins; Piperidines; Protein Binding; Rats; Structure-Activity Relationship; Symporters; Tissue Distribution | 2015 |
Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.
Topics: Aniline Compounds; DNA; DNA Cleavage; Guanine; Kinetics; Molecular Structure; Oxidation-Reduction; Piperidines; RNA; RNA Cleavage; Time Factors | 2015 |
Convergent QSAR studies on a series of NK₃ receptor antagonists for schizophrenia treatment.
Topics: Cyclopropanes; Humans; Piperidines; Quantitative Structure-Activity Relationship; Receptors, Neurokinin-3; Schizophrenia | 2016 |
Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Cells, Cultured; Drug Discovery; HIV Reverse Transcriptase; Humans; Molecular Structure; Nitriles; Piperidines; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2015 |
Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.
Topics: Combinatorial Chemistry Techniques; Drug Discovery; Heterocyclic Compounds; Lithium; Molecular Structure; Organometallic Compounds; Piperazine; Piperazines; Piperidines; Pyrrolidines; Small Molecule Libraries | 2015 |
Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Bacterial Agents; Cattle; Chloramphenicol; Deoxyguanosine; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Free Radicals; Genes, p53; Humans; Hydroxides; Hydroxylamines; Leukemia; Oxygen; Piperidines; Reactive Oxygen Species; Spectrophotometry, Ultraviolet; Thymus Gland | 2015 |
Microwave assisted efficient synthesis of diphenyl substituted pyrazoles using PEG-600 as solvent - A green approach.
Topics: Anti-Bacterial Agents; Biphenyl Compounds; Chalcones; Escherichia coli; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microwaves; Piperidines; Polyethylene Glycols; Pyrazoles; Solvents; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus | 2015 |
Stereoselective Synthesis of (R)-3-Methylthalidomide by Piperidin-2-one Ring Assembly Approach.
Topics: Chemistry Techniques, Synthetic; Hydrogen-Ion Concentration; Piperidines; Piperidones; Stereoisomerism; Thalidomide | 2015 |
Synthesis and biological evaluation of novel piperidine-benzodioxole derivatives designed as potential leishmanicidal drug candidates.
Topics: Antiprotozoal Agents; Benzodioxoles; Drug Discovery; Humans; Inhibitory Concentration 50; Leishmania; Molecular Structure; Piperidines | 2015 |
Asymmetric catalytic cascade reactions for constructing diverse scaffolds and complex molecules.
Topics: Biological Products; Catalysis; Cyclobutanes; Indoles; Molecular Conformation; Piperidines; Stereoisomerism | 2015 |
Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.
Topics: Cell Line; Drug Discovery; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Isoenzymes; Models, Molecular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Conformation; Substrate Specificity | 2015 |
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.
Topics: Biological Phenomena; Clopidogrel; Humans; Microsomes, Liver; Piperidines; Platelet Aggregation Inhibitors; Prodrugs; Stereoisomerism; Ticlopidine | 2015 |
Rhodnius prolixus smells repellents: Behavioural evidence and test of present and potential compounds inducing repellency in Chagas disease vectors.
Topics: Animals; Behavior, Animal; Chagas Disease; DEET; Disease Vectors; Feeding Behavior; Humans; Insect Repellents; Nymph; Odorants; Piperidines; Rhodnius; Smell | 2015 |
Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors.
Topics: Amides; Drug Design; HEK293 Cells; Humans; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Protein Binding; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2015 |
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents.
Topics: Animals; Cell Membrane Permeability; Dogs; Drug Design; Drug Evaluation, Preclinical; Half-Life; Madin Darby Canine Kidney Cells; Narcotic Antagonists; Piperidines; Protein Binding; Receptors, Opioid, kappa; Tetrahydroisoquinolines | 2015 |
Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors.
Topics: Animals; Drug Discovery; Humans; Inhibitory Concentration 50; Mexiletine; Mice; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Piperidines; Voltage-Gated Sodium Channel Blockers | 2015 |
The mechanism of excited-state proton transfer in 1-naphthol-piperidine clusters.
Topics: Hydrogen Bonding; Models, Molecular; Naphthols; Piperidines; Protons; Quantum Theory | 2015 |
Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.
Topics: Amino Acids; Clorgyline; Monoamine Oxidase Inhibitors; Morpholines; Piperidines; Quantitative Structure-Activity Relationship; Triazines | 2015 |
Bifunctional crosslinking ligands for transthyretin.
Topics: Animals; Binding Sites; Cross-Linking Reagents; Humans; Ligands; Mice; Mice, Inbred C57BL; Models, Molecular; Piperidines; Prealbumin; Protein Structure, Quaternary; Thyroxine | 2015 |
A computational study of the chlorination and hydroxylation of amines by hypochlorous acid.
Topics: Amines; Chlorine; Hydroxylation; Hypochlorous Acid; Molecular Docking Simulation; Molecular Structure; Morpholines; Piperidines | 2015 |
Ozonation of piperidine, piperazine and morpholine: Kinetics, stoichiometry, product formation and mechanistic considerations.
Topics: Kinetics; Morpholines; Ozone; Pharmaceutical Preparations; Piperazine; Piperazines; Piperidines; Waste Disposal, Fluid; Water Pollutants, Chemical | 2016 |
Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines.
Topics: Calcitonin Gene-Related Peptide; Cell Line, Tumor; Cell Membrane Permeability; Humans; Indazoles; Inhibitory Concentration 50; Piperazine; Piperazines; Piperidines; Quinazolinones; Structure-Activity Relationship | 2016 |
A Novel Mechanistic Study on Ultrasound-Assisted, One-Pot Synthesis of Functionalized Benzimidazo[2,1-b]quinazolin-1(1H)-ones.
Topics: Benzimidazoles; Catalysis; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Models, Molecular; Piperidines; Quinazolinones; Sonication | 2016 |
Probing Framework-Restricted Metal Axial Ligation and Spin State Patterns in a Post-Synthetically Reduced Iron-Porphyrin-Based Metal-Organic Framework.
Topics: Heme; Iron; Models, Molecular; Organometallic Compounds; Oxidation-Reduction; Piperidines; Spectrometry, X-Ray Emission; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2016 |
Click-based synthesis and antitubercular evaluation of novel dibenzo[b,d]thiophene-1,2,3-triazoles with piperidine, piperazine, morpholine and thiomorpholine appendages.
Topics: Antitubercular Agents; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Morpholines; Mycobacterium tuberculosis; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Thiophenes; Triazoles | 2016 |
Piperidine derivatives as nonprostanoid IP receptor agonists 2.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Epoprostenol; Structure-Activity Relationship | 2016 |
Enantioselective synthesis and antioxidant activity of 3,4,5-substituted piperidine derivatives.
Topics: Antioxidants; Dose-Response Relationship, Drug; Molecular Structure; Piperidines; Stereoisomerism; Structure-Activity Relationship | 2016 |
One-pot multiple reactions: asymmetric synthesis of 2,6-cis-disubstituted piperidine alkaloids from chiral aziridine.
Topics: Alkaloids; Aziridines; Chemistry Techniques, Synthetic; Ketones; Piperidines; Stereoisomerism | 2016 |
Piperidine-based glycodendrons as protein N-glycan prosthetics.
Topics: Dendrimers; Humans; Molecular Structure; Piperidines; Polysaccharides; Proteins; Triazines | 2016 |
Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent.
Topics: Apoptosis; Chemistry Techniques, Synthetic; Humans; Indicators and Reagents; MCF-7 Cells; Models, Molecular; Molecular Conformation; Piperidines; Thiazolidines | 2016 |
Oxa-Pictet-Spengler reaction as key step in the synthesis of novel σ receptor ligands with 2-benzopyran structure.
Topics: Animals; Benzopyrans; Guinea Pigs; Ligands; Piperidines; Rats; Receptors, sigma; Spiro Compounds | 2016 |
Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis.
Topics: Aldehydes; Alzheimer Disease; Amyloid Precursor Protein Secretases; Chemistry Techniques, Synthetic; Drug Discovery; Humans; Ketones; Piperidines; Stereoisomerism | 2016 |
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.
Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Piperidines; Protein Kinase Inhibitors; Structure-Activity Relationship | 2016 |
Suppressing the epimerization of endothioamide peptides during Fmoc/t-Bu-based solid phase peptide synthesis.
Topics: Amino Acid Sequence; Bacterial Proteins; Dimethylformamide; Fluorenes; Models, Molecular; Peptides; Peptidomimetics; Piperidines; Protein Domains; Protein Engineering; Protein Structure, Secondary; Solid-Phase Synthesis Techniques; Stereoisomerism; Thioamides | 2016 |
Deciphering Piperidine Formation in Polyketide-Derived Indolizidines Reveals a Thioester Reduction, Transamination, and Unusual Imine Reduction Process.
Topics: Acyl Carrier Protein; Acyl-CoA Dehydrogenases; Biosynthetic Pathways; Imines; Indolizidines; Piperidines; Polyketides; Streptomyces | 2016 |
Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Catalysis; Enzyme Inhibitors; Humans; Hydrogenation; Iridium; Molecular Conformation; Palladium; Piperidines; Stereoisomerism | 2016 |
Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Topics: Amines; Anaplastic Lymphoma Kinase; Animals; Crizotinib; Drug Resistance, Neoplasm; Heterografts; Humans; Mice; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones | 2017 |
Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.
Topics: Antimalarials; Drug Resistance; Humans; Life Cycle Stages; Malaria, Falciparum; Mutation; Piperidines; Plasmodium falciparum; Protozoan Proteins | 2016 |
Rosbin, a synthetic small molecule, induces A549 cells apoptosis through a ROS-mediated pathway.
Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Caspase 9; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Mitochondria; Piperidines; Reactive Oxygen Species; Thiophenes | 2017 |
Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Stability; Humans; Mice; Molecular Docking Simulation; Peptides; Piperazines; Piperidines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Conformation | 2017 |
Aqueous Instability of δ-Fluorobutylpiperidines.
Topics: Drug Stability; Fluorine; Kinetics; Magnetic Resonance Spectroscopy; Piperidines; Spectrometry, Mass, Electrospray Ionization; Water | 2017 |
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.
Topics: Administration, Intravenous; Animals; Area Under Curve; Binding Sites; Drug Evaluation, Preclinical; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Half-Life; Histamine; Inhibitory Concentration 50; Molecular Docking Simulation; Naphthalenes; Piperidines; Potassium; Proton Pump Inhibitors; Rats; ROC Curve; Spiro Compounds; Structure-Activity Relationship | 2017 |
Substitution determination of Fmoc-substituted resins at different wavelengths.
Topics: Composite Resins; Peptide Fragments; Peptides; Piperidines; Solid-Phase Synthesis Techniques | 2017 |
Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation.
Topics: Antineoplastic Agents; Antioxidants; Boronic Acids; Cell Death; Cell Membrane Permeability; Drug Carriers; Esters; Glucose Oxidase; Glutathione; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Indolequinones; Methacrylates; Microscopy, Electron, Transmission; Nanostructures; Neoplasms; Piperidines; Polyethylene Glycols; Proof of Concept Study | 2017 |
Trace level determination of chloroacetyl chloride and degradation products by derivatization gas chromatography.
Topics: Acetates; Chromatography, Gas; Ethylene Dichlorides; Flame Ionization; Limit of Detection; Piperidines | 2018 |
The fentanyl family: A distinguished medical history tainted by abuse.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Piperidines; Substance-Related Disorders | 2018 |
Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
Topics: Aged; Animals; Chick Embryo; Cholesterol Ester Transfer Proteins; Humans; Hypertriglyceridemia; Male; Mesocricetus; Piperidines; Rats; Structure-Activity Relationship | 2017 |
Quick Identification of Piperidine Alkaloid from Roots of Grewia nervosa and Their Glucosidase Inhibitory Activity.
Topics: Alkaloids; alpha-Glucosidases; Binding Sites; Chromatography, High Pressure Liquid; Glycoside Hydrolase Inhibitors; Grewia; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Molecular Docking Simulation; Piperidines; Plant Extracts; Plant Roots; Protein Structure, Tertiary | 2017 |
Accessing 2-substituted piperidine iminosugars by organometallic addition/intramolecular reductive amination: aldehyde vs. nitrone route.
Topics: Aldehydes; Amination; Nitrogen Oxides; Organometallic Compounds; Oxidation-Reduction; Piperidines; Stereoisomerism | 2017 |
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
Topics: Administration, Oral; Animals; Benzothiazoles; Biological Availability; Cholestasis; Dogs; Drug Evaluation, Preclinical; Fibroblast Growth Factors; Gene Expression Regulation; Humans; Isoxazoles; Male; Microsomes, Liver; Non-alcoholic Fatty Liver Disease; Piperidines; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Triglycerides | 2017 |
Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima.
Topics: Ailanthus; Amides; Flavonoids; Fruit; Phenols; Piperidines; Plant Extracts | 2017 |
"In silico" study of the binding of two novel antagonists to the nociceptin receptor.
Topics: Amino Acid Sequence; Amino Acids; Computer Simulation; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Structure; Nociceptin Receptor; Piperidines; Protein Binding; Receptors, Opioid; Structure-Activity Relationship | 2018 |
Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery.
Topics: Catalysis; Cyclization; Drug Design; Ethers, Cyclic; Gold; Piperidines; Small Molecule Libraries | 2018 |
Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.
Topics: Amides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Phosphoric Diester Hydrolases; Piperidines; Pyrophosphatases; Quinazolines; Structure-Activity Relationship | 2018 |
Automatic procedures for the synthesis of difficult peptides using oxyma as activating reagent: A comparative study on the use of bases and on different deprotection and agitation conditions.
Topics: Acylation; Amino Acid Sequence; Ethylamines; Morpholines; Peptides; Piperidines; Pregnadienes; Protein Aggregates; Pyridines; Solid-Phase Synthesis Techniques | 2018 |
Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists.
Topics: Alkanes; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Drug Design; Glucose Tolerance Test; Half-Life; Humans; Hypoglycemic Agents; Microsomes, Liver; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2018 |
A novel flurophore-cyano-carboxylic-Ag microhybrid: Enhanced two photon absorption for two-photon photothermal therapy of HeLa cancer cells by targeting mitochondria.
Topics: Acetates; Acetonitriles; Carbazoles; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Dyes; HeLa Cells; Humans; Metal Nanoparticles; Mitochondria; Photons; Phototherapy; Piperidines; Silver; Surface Plasmon Resonance | 2018 |
Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.
Topics: Class I Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Protein Kinase Inhibitors; Pyrrolidines; Quinazolines; Structure-Activity Relationship | 2018 |
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Topics: 3C Viral Proteases; Animals; Antiviral Agents; Cats; Cell Death; Cells, Cultured; Chlorocebus aethiops; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Middle East Respiratory Syndrome Coronavirus; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Vero Cells; Viral Proteins | 2018 |
Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT
Topics: Allosteric Regulation; Allosteric Site; Amides; Animals; Azepines; Calcium; CHO Cells; Cricetinae; Cricetulus; Drug Design; Half-Life; Indoles; Locomotion; Molecular Docking Simulation; Piperidines; Protein Isoforms; Protein Structure, Tertiary; Rats; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship | 2019 |
Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Humans; KCNQ Potassium Channels; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.
Topics: Administration, Oral; Animals; Benzimidazoles; Binding Sites; Biological Availability; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Half-Life; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Piperidines; Protease Inhibitors; Protein Structure, Tertiary; Rats; Renin; Structure-Activity Relationship | 2018 |
Piperidine Alkaloids with Diverse Skeletons from Anacyclus pyrethrum.
Topics: Alkaloids; Asteraceae; Chromatography, High Pressure Liquid; Organic Chemicals; Piperidines; Plant Roots; Stereoisomerism | 2018 |
Anti-
Topics: Acyclic Monoterpenes; Alkenes; Anti-Infective Agents; Apiaceae; Distillation; Escherichia coli; Gas Chromatography-Mass Spectrometry; Hemlock; Microbial Sensitivity Tests; Oils, Volatile; Piperidines; Plant Leaves; Pseudomonas aeruginosa; Sicily | 2019 |
Synthesis and in vivo anti-ulcer evaluation of some novel piperidine linked dihydropyrimidinone derivatives.
Topics: Animals; Anti-Ulcer Agents; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Models, Molecular; Molecular Structure; Piperidines; Pyrimidinones; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship | 2018 |
Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation.
Topics: Amyloid beta-Peptides; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Protein Aggregates; Small Molecule Libraries; Structure-Activity Relationship | 2018 |
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Topics: Drug Design; HeLa Cells; Humans; Indoles; Models, Molecular; Piperidines; Protein Conformation; ras Proteins; Signal Transduction; SOS1 Protein; Structure-Activity Relationship | 2018 |
Design and synthesis of bridged piperidine and piperazine isosteres.
Topics: Animals; Bridged Bicyclo Compounds; Crystallography, X-Ray; Dopamine Antagonists; Drug Design; ERG1 Potassium Channel; Humans; Magnetic Resonance Spectroscopy; Mice; Piperazine; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship | 2018 |
Identification of a novel series of potent and selective CCR6 inhibitors as biological probes.
Topics: Amines; Animals; B-Lymphocytes; Cell Movement; CHO Cells; Cricetulus; Cyclohexanes; Dose-Response Relationship, Drug; Haplorhini; Humans; Molecular Structure; Piperidines; Receptors, CCR6; Small Molecule Libraries; Structure-Activity Relationship | 2018 |
Formulation and evaluation of 4-benzylpiperidine drug-in-adhesive matrix type transdermal patch.
Topics: Adhesives; Administration, Cutaneous; Humans; Membranes, Artificial; Piperidines; Polyenes; Polymers; Silicones; Skin; Transdermal Patch | 2018 |
New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.
Topics: Cell Line, Tumor; Humans; Ligands; Piperidines; Receptors, sigma | 2018 |
Discovery of novel spiro[chromane-2,4'-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists.
Topics: Administration, Oral; Biological Availability; Chromans; GTP-Binding Proteins; Piperidines | 2018 |
Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines.
Topics: Carbon; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Morpholines; Piperazines; Piperidines | 2018 |
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M
Topics: Animals; Cells, Cultured; CHO Cells; Cricetulus; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Osteopontin; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Spiro Compounds; Structure-Activity Relationship; Xenopus | 2019 |
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Carrier Proteins; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Humans; Ligands; Lymnaea; Models, Molecular; Molecular Structure; Nicotinic Agonists; Piperidines; Structure-Activity Relationship | 2018 |
Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker.
Topics: Antiprotozoal Agents; Piperidines; Quinolines; Structure-Activity Relationship; Tetrazoles | 2019 |
Oxidation of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Leads to Substantial DNA-Histone Cross-Links within Nucleosome Core Particles.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Deoxyguanosine; DNA; DNA Damage; Ethylamines; Ferricyanides; Histones; Kinetics; Nucleosomes; Oxidation-Reduction; Piperidines | 2018 |
Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis.
Topics: Alkaloids; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania; Leishmaniasis; Molecular Docking Simulation; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Senna Plant; Structure-Activity Relationship | 2018 |
Detection of Fentanyl Analogs and Synthetic Opioids in Real Hair Samples.
Topics: Adolescent; Adult; Analgesics, Opioid; Benzamides; Biomarkers; Chromatography, Liquid; Designer Drugs; Fentanyl; Furans; Hair; Humans; Illicit Drugs; Oxycodone; Piperidines; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol; Young Adult | 2019 |
Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites.
Topics: Amino Acid Sequence; Amino Acids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Carriers; Drug Design; Drug Liberation; Ferritins; Humans; Models, Molecular; Molecular Structure; Nanocomposites; Particle Size; Piperidines; Protein Binding; Signal Transduction; Structure-Activity Relationship; Surface Properties | 2018 |
Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Hydrazones; Models, Molecular; Molecular Structure; Neuroprotective Agents; Picrates; Piperidines; Structure-Activity Relationship; Sulfonic Acids | 2019 |
Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Proteolysis; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Insight into the selective mechanism of phosphoinositide 3-kinase γ with benzothiazole and thiazolopiperidine γ-specific inhibitors by in silico approaches.
Topics: Benzothiazoles; Binding Sites; Catalytic Domain; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Piperidines; Thermodynamics | 2019 |
Acetate Kinase (AcK) is Essential for Microbial Growth and Betel-derived Compounds Potentially Target AcK, PhoP and MDR Proteins in M. tuberculosis, V. cholerae and Pathogenic E. coli: An in silico and in vitro Study.
Topics: Acetate Kinase; Anti-Bacterial Agents; Bacterial Proteins; Carboxylic Acids; Chlorogenic Acid; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Enzyme Inhibitors; Escherichia coli; Furans; Lignans; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Mycobacterium tuberculosis; Piper betle; Piperidines; Structure-Activity Relationship | 2018 |
Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors.
Topics: Animals; Cells, Cultured; Ceramides; Enzyme Inhibitors; Fibroblasts; Glucosylceramidase; Humans; Hydrolysis; Imino Pyranoses; Imino Sugars; Isomerism; Lysosomes; Melanoma, Experimental; Mice; Molecular Docking Simulation; Molecular Structure; Piperidines; Protein Binding; Pyrrolidines; Structure-Activity Relationship | 2019 |
Efficient Synthesis of UDP-Furanoses via 4,5-Dicyanoimidazole(DCI)-Promoted Coupling of Furanosyl-1-Phosphates with Uridine Phosphoropiperidate.
Topics: Arabinose; Imidazoles; Imino Furanoses; Nucleosides; Phosphates; Piperidines; Uridine | 2019 |
Synthesis,
Topics: Alcohols; Autoradiography; Chemistry Techniques, Synthetic; Halogenation; Humans; Isotope Labeling; Ligands; Piperidines; Radiochemistry; Receptors, CCR2; Tritium | 2019 |
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
Topics: Animals; Chemistry Techniques, Synthetic; Disease Models, Animal; Drug Design; Fatty Liver; Male; Mice; Piperidines; Rats; Retinol-Binding Proteins, Plasma; Tissue Distribution | 2019 |
Synthesis, spectral analysis and biological evaluation of sulfamoyl and 1,3,4-oxadiazole derivatives of 3-pipecoline.
Topics: Anti-Bacterial Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Piperidines; Spectrophotometry, Infrared; Sulfonamides; Urease | 2019 |
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.
Topics: Administration, Oral; Animals; Cell Line, Tumor; Drug Discovery; ERG1 Potassium Channel; HCT116 Cells; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Piperidines; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2019 |
Characterization of stable and reactive metabolites of piperine formed on incubation with human liver microsomes.
Topics: Acetylcysteine; Alkaloids; Benzodioxoles; Chromatography, High Pressure Liquid; Glutathione; Humans; Isomerism; Microsomes, Liver; Piperidines; Polyunsaturated Alkamides; Tandem Mass Spectrometry | 2019 |
Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Jurkat Cells; MCF-7 Cells; Melanoma, Experimental; Mice; Molecular Docking Simulation; Piperazine; Piperidines; Receptor, EphB3; Repressor Proteins | 2019 |
Total Synthesis of (-)-Himeradine A.
Topics: Catalysis; Cyclization; Molecular Structure; Piperidines; Pyridines; Quinolizines; Stereoisomerism | 2019 |
Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β-Position to the Amino Group.
Topics: Hydrogen Bonding; Molecular Structure; Piperidines; Solubility | 2020 |
A Combination of Pharmacophore and Docking-based Virtual Screening to Discover new Tyrosinase Inhibitors.
Topics: Agaricales; Drug Discovery; Drug Evaluation, Preclinical; Enzyme Inhibitors; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Piperazine; Piperidines | 2020 |
One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists.
Topics: Click Chemistry; Humans; Molecular Structure; Piperazine; Piperidines; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2019 |
Search for new multi-target compounds against Alzheimer's disease among histamine H
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzopyrans; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Histamine H3 Antagonists; Horses; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Piperidines; Receptors, Histamine H3; Structure-Activity Relationship | 2020 |
TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism.
Topics: Animals; Binding Sites; Calcium Channels; Drug Design; Humans; Isothiocyanates; Ligands; Models, Structural; Molecular Docking Simulation; Mutagenesis; Oximes; Piperidines; Propofol; Protein Domains; Rats; Species Specificity; TRPA1 Cation Channel | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Formaldehyde; Humans; Hyperalgesia; Inflammation; Molecular Docking Simulation; Molecular Structure; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines; Tryptophan | 2020 |
Phenoxyethyl Piperidine/Morpholine Derivatives as PAS and CAS Inhibitors of Cholinesterases: Insights for Future Drug Design.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Enzyme Activation; Humans; Models, Molecular; Molecular Dynamics Simulation; Morpholines; Piperidines | 2019 |
Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dantrolene; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Muscle Relaxants, Central; Piperazine; Piperidines; Structure-Activity Relationship | 2020 |
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives.
Topics: Antimalarials; Human Umbilical Vein Endothelial Cells; Humans; Piperidines; Plasmodium falciparum | 2020 |
Design of iodinated radioligands for SPECT imaging of central human 5-HT
Topics: Animals; Brain Chemistry; CHO Cells; Cricetulus; Dioxanes; Humans; Iodine Radioisotopes; Ligands; Piperidines; Rats; Receptors, Serotonin, 5-HT4; Tomography, Emission-Computed, Single-Photon | 2020 |
Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain.
Topics: Amides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Guinea Pigs; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Molecular Structure; Neuralgia; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, sigma; Sciatic Nerve; Sigma-1 Receptor; Structure-Activity Relationship | 2020 |
Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach.
Topics: Alkaloids; Ethanol; Piperidines; Plant Extracts; Stereoisomerism; Withania | 2020 |
Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy.
Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Structure; Piperidines; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Serotonin Antagonists; Structure-Activity Relationship | 2020 |
Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors.
Topics: Antigens, Neoplasm; Benzenesulfonamides; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Hydrazines; Molecular Docking Simulation; Molecular Structure; Piperidines; Structure-Activity Relationship; Sulfonamides | 2020 |
A common strategy towards the synthesis of 1,4-dideoxy-1,4-imino-l-xylitol, deacetyl (+)-anisomycin and amino-substituted piperidine iminosugars.
Topics: Anisomycin; Imino Furanoses; Imino Sugars; Molecular Conformation; Piperidines; Stereoisomerism; Xylitol | 2020 |
Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.
Topics: Alkenes; Carbon; Molecular Structure; Nitrogen Oxides; Organophosphonates; Piperidines; Pyrroles; Stereoisomerism | 2020 |
A novel piperidine degradation mechanism in a newly isolated piperidine degrader Pseudomonas sp. strain KU43P.
Topics: Amide Synthases; Bacterial Proteins; Biodegradation, Environmental; Cytochrome P-450 Enzyme System; Escherichia coli; Genome, Bacterial; Metabolic Networks and Pathways; Multigene Family; Mutation; Phylogeny; Piperidines; Pseudomonas; Recombinant Proteins; Transcription, Genetic | 2020 |
Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study.
Topics: Crystallography, X-Ray; Darunavir; Drug Design; Enzyme Inhibitors; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Piperidines; Structure-Activity Relationship; Sulfonamides | 2020 |
Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein.
Topics: Antiviral Agents; Coumarins; Drug Design; Filoviridae; Molecular Targeted Therapy; Piperidines; Structure-Activity Relationship; Viral Envelope Proteins; Virus Internalization | 2020 |
Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors.
Topics: Binding Sites; Catalytic Domain; Drug Design; Enzyme Inhibitors; Humans; Indoles; Kinetics; Molecular Docking Simulation; Nicotinamide Phosphoribosyltransferase; Piperazine; Piperidines | 2020 |
Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
Topics: Amides; Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Molecular Structure; Piperazine; Piperidines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Structure-Activity Relationship | 2020 |
The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis.
Topics: Green Chemistry Technology; Peptides; Piperazine; Piperidines; Solid-Phase Synthesis Techniques | 2020 |
Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Chemistry Techniques, Synthetic; Drug Design; Nicotinic Antagonists; Oxadiazoles; Piperidines; Structure-Activity Relationship; Xenopus laevis | 2020 |
Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers.
Topics: Cell Survival; CRISPR-Cas Systems; Dendrimers; DNA; Gene Editing; Genetic Therapy; HEK293 Cells; HeLa Cells; Heparin; Humans; Peptides; Phosphatidylethanolamines; Piperidines; Spheroids, Cellular; Transfection | 2020 |
Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase.
Topics: Acetylcholinesterase; Benzamides; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Inhibitory Concentration 50; Molecular Dynamics Simulation; Permeability; Piperidines; Protein Conformation | 2020 |
Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine.
Topics: Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Gene Expression Regulation, Leukemic; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Humans; Lactones; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Morpholines; NF-kappa B p50 Subunit; Piperidines; Sesquiterpenes; Tyramine | 2020 |
Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding.
Topics: Adenosine Triphosphate; Binding Sites; Crystallography, X-Ray; Diphosphotransferases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Models, Molecular; Molecular Structure; Piperidines; Pterins; Structure-Activity Relationship | 2021 |
Structural modifications in the distal, regulatory region of histamine H
Topics: Animals; Anti-Obesity Agents; Body Weight; Dose-Response Relationship, Drug; Female; Histamine H3 Antagonists; Humans; Imidazoles; Ligands; Models, Molecular; Piperazine; Piperidines; Protein Binding; Rats, Wistar; Receptors, Histamine H3; Regulatory Sequences, Nucleic Acid; Structure-Activity Relationship | 2021 |
Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239.
Topics: Administration, Oral; Amides; Amines; Animals; Chemokine CXCL12; Crystallography, X-Ray; Dogs; Drug Evaluation, Preclinical; Half-Life; Humans; Inhibitory Concentration 50; Mice; Molecular Conformation; Piperidines; Protein Binding; Rats; Receptors, CXCR; Structure-Activity Relationship | 2020 |
Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of α,β-Unsaturated Ketones.
Topics: Combinatorial Chemistry Techniques; DNA; Gene Library; Ketones; Molecular Structure; Piperidines | 2021 |
Report - Synthesis of new antibacterial agents encompassing tosyl, piperidine, propanamide and 1,3,4-oxadiazole functionalities.
Topics: Anti-Bacterial Agents; Hydrazines; Microbial Sensitivity Tests; Oxadiazoles; Piperidines; Tosyl Compounds | 2020 |
Identification of a new class of HBV capsid assembly modulator.
Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Pyrazoles; Structure-Activity Relationship | 2021 |
Taming Radical Pairs in the Crystalline Solid State: Discovery and Total Synthesis of Psychotriadine.
Topics: Alkaloids; Carbon; Free Radicals; Indoles; Light; Molecular Conformation; Piperidines; Stereoisomerism | 2021 |
Discovery of Acyl-sulfonamide Na
Topics: Animals; Azetidines; Benzamides; Cells, Cultured; Drug Discovery; HEK293 Cells; Humans; NAV1.7 Voltage-Gated Sodium Channel; Piperidines; Rats, Sprague-Dawley; Sulfonamides; Voltage-Gated Sodium Channel Blockers | 2021 |
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Topics: Antiprotozoal Agents; Crystallography, X-Ray; Enzyme Inhibitors; Intramolecular Transferases; Leishmania donovani; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Piperidines | 2021 |
Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics.
Topics: Adenine; Adenosine; Magnetic Resonance Spectroscopy; Molecular Conformation; Nucleosides; Piperidines; Purine Nucleosides; Pyrimidinones; Pyrrolidines; Structure-Activity Relationship | 2021 |
Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cholinesterase Inhibitors; Donepezil; Humans; Ligands; Piperazines; Piperidines; Structure-Activity Relationship; Sulfonamides | 2021 |
Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants.
Topics: Anti-HIV Agents; Darunavir; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Viral; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Structure-Activity Relationship | 2021 |
A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis.
Topics: Alkaloids; Biosynthetic Pathways; Lycopodium; Metabolomics; Mixed Function Oxygenases; Oxidation-Reduction; Piperidines; Regulon; Sesquiterpenes; Transcriptome | 2021 |
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship | 2021 |
Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold.
Topics: Antineoplastic Agents; Binding Sites; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Monoacylglycerol Lipases; Piperidines; Recombinant Proteins; Structure-Activity Relationship; Sulfides | 2021 |
Dissection of the Enzymatic Process for Forming a Central Imidazopiperidine Heterocycle in the Biosynthesis of a Series
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Micromonospora; Mixed Function Oxygenases; Oxidation-Reduction; Peptides; Piperidines; Streptomyces; Thiazoles | 2021 |
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.
Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Piperidines; Structure-Activity Relationship; Thymine | 2021 |
Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.
Topics: Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Piperidines; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2021 |
Synthesis, Spectroscopic Analysis, and in Vitro/in Silico Biological Studies of Novel Piperidine Derivatives Heterocyclic Schiff-Mannich Base Compounds.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione Transferase; Heterocyclic Compounds; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Piperidines; Schiff Bases; Spectrophotometry, Infrared | 2021 |
Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Triazoles | 2021 |
Discovery of a cinnamyl piperidine derivative as new neddylation inhibitor for gastric cancer treatment.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cinnamates; Cullin Proteins; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Piperidines; Stomach Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Optimization of bifunctional piperidinamide derivatives as σ
Topics: Acetic Acid; Amides; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Guinea Pigs; Mice; Mice, Inbred ICR; Molecular Dynamics Simulation; Molecular Structure; Neuralgia; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship | 2021 |
Copper(I)-catalyzed tandem synthesis of 2-acylquinolines from 2-ethynylanilines and glyoxals.
Topics: Acetylene; Aniline Compounds; Catalysis; Copper; Cyclization; Glyoxal; Models, Chemical; Piperidines; Quinolines | 2021 |
Mimicking Elementary Reactions of Manganese Lipoxygenase Using Mn-hydroxo and Mn-alkylperoxo Complexes.
Topics: Biomimetics; Catalytic Domain; Coordination Complexes; Fatty Acids, Unsaturated; Hydrogen; Ligands; Lipid Peroxides; Lipoxygenase; Manganese; Molecular Structure; Oxidation-Reduction; Oxygen; Piperidines | 2021 |
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ
Topics: Amnesia; Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Development; Guinea Pigs; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship; Tumor Cells, Cultured | 2022 |
Combining bio- and organocatalysis for the synthesis of piperidine alkaloids.
Topics: Piperidines | 2022 |
Synthesis of Aminoethyl-Substituted Piperidine Derivatives as σ
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Ligands; Lung Neoplasms; Male; Piperidines; Prostatic Neoplasms; Receptors, sigma; Structure-Activity Relationship | 2022 |
Synthesis and Solvent Dependent Fluorescence of Some Piperidine-Substituted Naphthalimide Derivatives and Consequences for Water Sensing.
Topics: Fluorescence; Naphthalimides; Piperidines; Solvents; Spectrometry, Fluorescence; Water | 2022 |