Compounds > piperidine
Page last updated: 2024-08-18

piperidine and piperazine

piperidine has been researched along with piperazine in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.44)18.7374
1990's1 (2.44)18.2507
2000's10 (24.39)29.6817
2010's21 (51.22)24.3611
2020's8 (19.51)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Barthalmus, GT; Mitchell, MK; Noga, EJ1
DeGrado, WF; Jackson, S; Mousa, S; Olson, RE; Rafalski, M; Rockwell, A; Roderick, J; Xue, CB1
Hasegawa, S; Hirota, TK; Komoto, T; Kotake, J; Koya, H; Otsuka, M; Sakamoto, T; Sato, S1
Das, MM; Lalitha, M; Murthy, BN; Prabhakar, T; Rao, GB; Rao, NS1
Farrell, N; Gibson, D; Moshel, O; Najajreh, Y; Peleg-Shulman, T1
Chen, KH; Liao, WS; Lin, CE; Lin, WY1
Durgun, M; Emul, M; Innocenti, A; Scozzafava, A; Supuran, CT; Turkmen, H; Vullo, D; Yilmaztekin, S1
Alonso, C; Fuertes, MA; Gibson, D; Iborra, S; Martínez, E; Najajreh, Y; Nguewa, PA; Pérez, JM1
Kim, JY; Mehanna, AS1
Dios, R; Fiorentino, A; Gilbert, KM; Misra, M; Pandit, D; Venanzi, CA1
Ahn, K; Beidler, D; Bhattacharya, K; Cravatt, BF; Johnson, DS; Kamtekar, S; Lazerwith, S; Liimatta, M; Long, JZ; McKinney, MK; Mileni, M; Sadagopan, N; Smith, SE; Stevens, RC; Stiff, C; Swaney, S; Van Becelaere, K; Weerapana, E; Zhang, Y1
Andrésson, T; Bedell, L; Bhagat, N; Gurney, M; Halldorsdottir, G; Kiselyov, A; Mamat, B; Sandanayaka, V; Sigthorsdottir, H; Singh, J1
Gilbert, KM; Misra, M; Pandit, D; Roosma, W; Skawinski, WJ; Venanzi, CA1
Arora, J; Balestra, M; Breysse, N; Brockel, B; Brown, DG; Brugel, TA; Brush, KA; Chhajlani, V; Gadient, RA; Hightower, C; Hinkley, L; Hoesch, V; Isaac, M; Kang, J; King, MM; Koether, GM; McCauley, JP; McLaren, FM; Panko, LM; Simpson, TR; Slassi, A; Smith, RW; Spear, N; Sygowski, LA; Wilson, JM; Woods, JM; Xiong, H; Zhang, M1
Anilkumar, GN; Carroll, CD; Dong, G; Hall, JW; Hobbs, DW; Jenh, CH; Jiang, Y; Kim, SH; Kozlowski, JA; McGuinness, BF; Rosenblum, SB; Schulman, I; Shao, Y; Shih, NY; Shu, Y; Wong, MK; Yu, W; Zawacki, LG; Zeng, Q1
Chonan, T; Hiratate, A; Io, F; Koretsune, H; Ohoka-Sugita, A; Oi, T; Tanaka, H; Wakasugi, D; Yamamoto, D; Yashiro, M1
Barlocco, D; Costantino, L1
Lokanatha Rai, KM; Prashanth, MK; Revanasiddappa, HD; Veeresh, B1
Christ, F; Debnath, B; Debyser, Z; Kuang, Y; Neamati, N; Otake, H; Serrao, E1
Aaltonen, N; Häyrinen, J; Käsnänen, H; Korhonen, J; Kuusisto, A; Laitinen, JT; Laitinen, T; Lehtonen, M; Navia-Paldanius, D; Nevalainen, T; Pantsar, T; Pasonen-Seppänen, S; Poso, A; Ribas, CR; Rönkkö, J; Savinainen, JR; Takabe, P1
Amanlou, M; Arjmand, M; Daha, FJ; Ghandi, M; Hasani Bozcheloie, A; Sadeghzadeh, M; Sheibani, S1
Bahadur, V; Falabella, M; Giuffrè, A; Kumar, Y; Mastronicola, D; Pucillo, LP; Sarti, P; Singh, BK; Tiwari, HK1
Hu, MJ; Li, Q; Liu, RY; Ma, TZ; Ma, WF; Yang, HK; You, WW; Zhao, PL; Zhou, ZZ1
Korhonen, J; Kuusisto, A; Laitinen, JT; Laitinen, T; Navia-Paldanius, D; Nevalainen, TJ; Parkkari, T; Patel, JZ; Savinainen, JR; van Bruchem, J1
Albert, CR; Bringmann, G; Bruhn, H; Buechold, C; Cecil, A; Engstler, M; Fuß, A; Goebel, T; Holzgrabe, U; Krohne, G; Mathein, D; Merget, B; Ponte-Sucre, A; Schirmeister, T; Schlesinger, S; Sotriffer, CA; Stich, A; Tischer, M1
Atobe, M; Bond, PS; Fairlamb, IJ; Haji-Cheteh, C; Hubbard, RE; Lüthy, M; O'Brien, P; Wheldon, MC1
Jewell, KS; Lutze, HV; Reisz, E; Schmidt, TC; Schmidt, W; Tekle-Röttering, A; Ternes, TA1
Beno, BR; Chaturvedula, PV; Civiello, RL; Conway, CM; Dubowchik, GM; Han, X; Herbst, JJ; Macor, JE; Xu, C1
Kantevari, S; Pulipati, L; Sriram, D; Yogeeswari, P1
Gloanec, P; Goument, B; Hanessian, S; Hocine, S; Le Tiran, A; Maertens, G; Mirguet, O; Öney, E; Reyes, MAV; Saavedra, OM; Vece, V1
Adhikari, N; Amin, SA; Bobde, Y; Ganesh, R; Ghosh, B; Jha, T; Trivedi, P1
De Luca, L; Garon, A; Germanò, MP; Gitto, R; Ielo, L; Langer, T; Pace, V; Rapisarda, A; Seidel, T; Vittorio, S1
Bashetti, N; Damuka, N; Devanathan, S; Mintz, A; Prasanna, B; Seelam, NV; Shanmukha Kumar, JV; Solingapuram Sai, KK1
Aoyama, H; Doura, T1
Abe, H; Asawa, Y; Katsuragi, K; Makino, K; Nakamura, H; Nomura, M; Ogino, Y; Okazawa, M; Oyama, T; Sakamoto, Y; Sato, A; Shibasaki, Y; Takahashi, H; Tanuma, N; Tanuma, SI; Uchiumi, F; Yamazaki, H; Yoshimori, A1
Chen, Y; Gao, L; Hu, J; Huang, L; Song, T; Yin, L; Zhang, X1
Albericio, F; Álvarez, C; Cárdenas, C; Gauna, A; Guzmán, F; Luna, O; Román, T1
Agarwal, S; Asati, V; Bhattacharya, S; Kashaw, SK; Mallick, C; Parwani, D; Rathore, A1
Bednarski, M; Bresinsky, M; Elz, S; Höring, C; Karcz, T; Kieć-Kononowicz, K; Kotańska, M; Kuder, KJ; Latacz, G; Mika, K; Mönnich, D; Nagl, M; Pockes, S; Podlewska, S; Seibel, U; Siwek, A; Stark, H; Szczepańska, K1
Bozzola, T; Ellervik, U; Johnsson, RE; Nilsson, UJ1

Reviews

3 review(s) available for piperidine and piperazine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
Ghrelin receptor modulators and their therapeutic potential.
    Future medicinal chemistry, 2009, Volume: 1, Issue:1

    Topics: Azoles; Drug Discovery; Ghrelin; Humans; Piperazine; Piperazines; Piperidines; Receptors, Ghrelin; Spiro Compounds; Structure-Activity Relationship

2009
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents.
    Mini reviews in medicinal chemistry, 2021, Volume: 21, Issue:3

    Topics: Animals; Antipsychotic Agents; Humans; Piperazine; Piperidines; Structure-Activity Relationship

2021

Other Studies

38 other study(ies) available for piperidine and piperazine

ArticleYear
Cyclic amines are selective cytotoxic agents for pigmented cells.
    Cell biology international reports, 1986, Volume: 10, Issue:4

    Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Drug Synergism; Melanins; Melanoma; Mice; Morpholines; Pigmentation; Piperazine; Piperazines; Piperidines; Theophylline

1986
Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid.
    Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4

    Topics: Alanine; Alkylation; Animals; Aspartic Acid; Benzamides; Benzamidines; Benzoates; Benzoic Acid; beta-Alanine; Carbamates; Esterases; Humans; Liver; Magnetic Resonance Spectroscopy; Oligopeptides; Piperazine; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Structure-Activity Relationship; Sulfonamides; Swine

1997
New strong fibrates with piperidine moiety.
    Chemical & pharmaceutical bulletin, 2000, Volume: 48, Issue:12

    Topics: Animals; Disease Models, Animal; Hypercholesterolemia; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Piperazine; Piperazines; Piperidines; Propionates; Rats; Rats, Sprague-Dawley

2000
Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2002, Volume: 58, Issue:12

    Topics: Amines; Heterocyclic Compounds; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Morpholines; Nitrogen Isotopes; Piperazine; Piperazines; Piperidines; Solvents

2002
Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2003, Volume: 8, Issue:1-2

    Topics: Amines; Animals; Binding Sites; Horses; Hydrogen Bonding; Isomerism; Ligands; Methionine; Myoglobin; Organoplatinum Compounds; Picolines; Piperazine; Piperazines; Piperidines; Protein Binding; Protein Folding; Spectrometry, Mass, Electrospray Ionization; Static Electricity; Ubiquitin

2003
Influence of pH on electrophoretic behavior of phenothiazines and determination of pKa values by capillary zone electrophoresis.
    Electrophoresis, 2003, Volume: 24, Issue:18

    Topics: Buffers; Cyclodextrins; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Phenothiazines; Piperazine; Piperazines; Piperidines; Promethazine; Stereoisomerism

2003
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
    Bioorganic & medicinal chemistry letters, 2005, Jan-17, Volume: 15, Issue:2

    Topics: Acetazolamide; Amines; Biomarkers, Tumor; Carbonic Anhydrase Inhibitors; Catalysis; Cytosol; Heterocyclic Compounds; Humans; Isoenzymes; Morpholines; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Sulfanilamide; Sulfanilamides

2005
Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum.
    Journal of inorganic biochemistry, 2005, Volume: 99, Issue:3

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Butylamines; Cations; Cisplatin; DNA; Leishmania infantum; Molecular Sequence Data; Picolines; Piperazine; Piperazines; Piperidines; Platinum Compounds; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Ubiquitin; Water

2005
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers.
    Bioorganic & medicinal chemistry, 2005, Jul-01, Volume: 13, Issue:13

    Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Diltiazem; Drug Design; Male; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Rats, Wistar; Salicylamides; Structure-Activity Relationship

2005
Singular value decomposition of torsional angles of analogs of the dopamine reuptake inhibitor GBR 12909.
    Journal of computational chemistry, 2006, Apr-15, Volume: 27, Issue:5

    Topics: Computer Simulation; Dopamine Uptake Inhibitors; Molecular Structure; Piperazine; Piperazines; Piperidines

2006
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
    Chemistry & biology, 2009, Apr-24, Volume: 16, Issue:4

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Crystallography, X-Ray; Endocannabinoids; Enzyme Inhibitors; Humans; Male; Pain; Piperazine; Piperazines; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Structure-Activity Relationship; Urea

2009
Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.
    Bioorganic & medicinal chemistry letters, 2010, May-01, Volume: 20, Issue:9

    Topics: Anti-Inflammatory Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship

2010
Conformational analysis of piperazine and piperidine analogs of GBR 12909: stochastic approach to evaluating the effects of force fields and solvent.
    Journal of molecular modeling, 2011, Volume: 17, Issue:1

    Topics: Models, Chemical; Piperazine; Piperazines; Piperidines; Solvents

2011
4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Allosteric Regulation; Amides; Humans; Microsomes, Liver; Piperazine; Piperazines; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Schizophrenia; Structure-Activity Relationship

2010
II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.
    Bioorganic & medicinal chemistry letters, 2011, Mar-01, Volume: 21, Issue:5

    Topics: Humans; Inhibitory Concentration 50; Molecular Structure; Piperazine; Piperazines; Piperidines; Pyridines; Receptors, CXCR3; Structure-Activity Relationship

2011
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
    Bioorganic & medicinal chemistry, 2011, Mar-01, Volume: 19, Issue:5

    Topics: Acetyl-CoA Carboxylase; Administration, Oral; Animals; Fluorine; Formic Acid Esters; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship

2011
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues.
    Bioorganic & medicinal chemistry letters, 2012, Dec-01, Volume: 22, Issue:23

    Topics: Amides; Animals; Anti-Bacterial Agents; Antidepressive Agents; Antifungal Agents; Antioxidants; Behavior, Animal; Candida albicans; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperazine; Piperazines; Piperidines

2012
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: Anti-HIV Agents; Cell Line; Drug Discovery; HIV Integrase; HIV-1; Humans; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Models, Molecular; Oxyquinoline; Piperazine; Piperazines; Piperidines; Protein Binding; Protein Conformation; Structure-Activity Relationship

2013
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
    Chemistry & biology, 2013, Mar-21, Volume: 20, Issue:3

    Topics: Animals; Benzodioxoles; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Monoacylglycerol Lipases; Piperazine; Piperazines; Piperidines; Rats; Substrate Specificity; Triazoles; Urea

2013
Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands.
    European journal of medicinal chemistry, 2013, Volume: 64

    Topics: Animals; Binding Sites; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Guinea Pigs; Ligands; Male; Molecular Conformation; Piperazine; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Structure-Activity Relationship

2013
O(2)-dependent efficacy of novel piperidine- and piperazine-based chalcones against the human parasite Giardia intestinalis.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1

    Topics: Antiprotozoal Agents; Caco-2 Cells; Cell Survival; Chalcones; Giardia lamblia; Humans; Piperazine; Piperazines; Piperidines

2014
One-pot synthesis and antiproliferative activity of novel 2,4-diaminopyrimidine derivatives bearing piperidine and piperazine moieties.
    European journal of medicinal chemistry, 2014, Sep-12, Volume: 84

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Piperazine; Piperazines; Piperidines; Pyrimidines; Structure-Activity Relationship

2014
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
    Bioorganic & medicinal chemistry, 2014, Dec-01, Volume: 22, Issue:23

    Topics: Amides; Amidohydrolases; Carbamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Monoacylglycerol Lipases; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship

2014
Anti-trypanosomal activities and structural chemical properties of selected compound classes.
    Parasitology research, 2015, Volume: 114, Issue:2

    Topics: Animals; Cell Line; Cysteine Proteases; Fumarates; Hydrogen-Ion Concentration; Macrophages; Mice; Mitochondria; Organelles; Piperazine; Piperazines; Piperidines; Trypanocidal Agents; Trypanosoma brucei brucei

2015
Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.
    Bioorganic & medicinal chemistry, 2015, Jun-01, Volume: 23, Issue:11

    Topics: Combinatorial Chemistry Techniques; Drug Discovery; Heterocyclic Compounds; Lithium; Molecular Structure; Organometallic Compounds; Piperazine; Piperazines; Piperidines; Pyrrolidines; Small Molecule Libraries

2015
Ozonation of piperidine, piperazine and morpholine: Kinetics, stoichiometry, product formation and mechanistic considerations.
    Water research, 2016, Jan-01, Volume: 88

    Topics: Kinetics; Morpholines; Ozone; Pharmaceutical Preparations; Piperazine; Piperazines; Piperidines; Waste Disposal, Fluid; Water Pollutants, Chemical

2016
Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines.
    Bioorganic & medicinal chemistry letters, 2016, Feb-15, Volume: 26, Issue:4

    Topics: Calcitonin Gene-Related Peptide; Cell Line, Tumor; Cell Membrane Permeability; Humans; Indazoles; Inhibitory Concentration 50; Piperazine; Piperazines; Piperidines; Quinazolinones; Structure-Activity Relationship

2016
Click-based synthesis and antitubercular evaluation of novel dibenzo[b,d]thiophene-1,2,3-triazoles with piperidine, piperazine, morpholine and thiomorpholine appendages.
    Bioorganic & medicinal chemistry letters, 2016, 06-01, Volume: 26, Issue:11

    Topics: Antitubercular Agents; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Morpholines; Mycobacterium tuberculosis; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Thiophenes; Triazoles

2016
Design and synthesis of bridged piperidine and piperazine isosteres.
    Bioorganic & medicinal chemistry letters, 2018, 08-15, Volume: 28, Issue:15

    Topics: Animals; Bridged Bicyclo Compounds; Crystallography, X-Ray; Dopamine Antagonists; Drug Design; ERG1 Potassium Channel; Humans; Magnetic Resonance Spectroscopy; Mice; Piperazine; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship

2018
Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Oct-01, Volume: 138

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Jurkat Cells; MCF-7 Cells; Melanoma, Experimental; Mice; Molecular Docking Simulation; Piperazine; Piperidines; Receptor, EphB3; Repressor Proteins

2019
A Combination of Pharmacophore and Docking-based Virtual Screening to Discover new Tyrosinase Inhibitors.
    Molecular informatics, 2020, Volume: 39, Issue:3

    Topics: Agaricales; Drug Discovery; Drug Evaluation, Preclinical; Enzyme Inhibitors; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Piperazine; Piperidines

2020
One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists.
    Bioorganic & medicinal chemistry letters, 2019, 12-01, Volume: 29, Issue:23

    Topics: Click Chemistry; Humans; Molecular Structure; Piperazine; Piperidines; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2019
Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene.
    Bioorganic & medicinal chemistry letters, 2020, 02-15, Volume: 30, Issue:4

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dantrolene; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Muscle Relaxants, Central; Piperazine; Piperidines; Structure-Activity Relationship

2020
Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors.
    Molecules (Basel, Switzerland), 2020, Aug-10, Volume: 25, Issue:16

    Topics: Binding Sites; Catalytic Domain; Drug Design; Enzyme Inhibitors; Humans; Indoles; Kinetics; Molecular Docking Simulation; Nicotinamide Phosphoribosyltransferase; Piperazine; Piperidines

2020
Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
    Bioorganic & medicinal chemistry letters, 2020, 10-15, Volume: 30, Issue:20

    Topics: Amides; Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Molecular Structure; Piperazine; Piperidines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Structure-Activity Relationship

2020
The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis.
    Amino acids, 2020, Volume: 52, Issue:8

    Topics: Green Chemistry Technology; Peptides; Piperazine; Piperidines; Solid-Phase Synthesis Techniques

2020
Structural modifications in the distal, regulatory region of histamine H
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Animals; Anti-Obesity Agents; Body Weight; Dose-Response Relationship, Drug; Female; Histamine H3 Antagonists; Humans; Imidazoles; Ligands; Models, Molecular; Piperazine; Piperidines; Protein Binding; Rats, Wistar; Receptors, Histamine H3; Regulatory Sequences, Nucleic Acid; Structure-Activity Relationship

2021
Sialic Acid 4-N-Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter.
    ChemMedChem, 2022, 12-05, Volume: 17, Issue:23

    Topics: N-Acetylneuraminic Acid; Piperazine; Sodium; Symporters

2022