Page last updated: 2024-08-16

piperazine and pyrrolidine

piperazine has been researched along with pyrrolidine in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Chen, C; Chen, CW; Fleck, BA; Jiang, W; Tran, JA; Tucci, FC1
Basista, K; Bojarski, AJ; Duszyńska, B; Martinez, J; Obniska, J; Pawłowski, M; Subra, G; Verdie, P; Zajdel, P1
Dai, H; Doran, SD; Piotrowski, DW; Prakash, C; Ryder, TF; Sharma, R; Sun, H1
Haq, W; Katti, SB; Kushwaha, RN; Mishra, A; Rawat, AK; Srivastava, AK; Srivastava, R1
Atobe, M; Bond, PS; Fairlamb, IJ; Haji-Cheteh, C; Hubbard, RE; Lüthy, M; O'Brien, P; Wheldon, MC1
Chavchich, M; Dračínský, M; Edstein, MD; Frydrych, J; Guddat, LW; Hocková, D; Janeba, Z; Keough, DT; Travis, J1
Ansari, A; Bhatta, RS; Bisen, AC; Goyal, N; Katiyar, S; Kumar, A; Mishra, G; Purkait, B; Ramalingam, K; Sanap, SN; Sashidhara, KV1

Reviews

1 review(s) available for piperazine and pyrrolidine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

7 other study(ies) available for piperazine and pyrrolidine

ArticleYear
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
    Bioorganic & medicinal chemistry letters, 2007, Dec-15, Volume: 17, Issue:24

    Topics: Amides; Carboxylic Acids; Chlorine Compounds; Cyclohexanes; Ligands; Molecular Structure; Piperazine; Piperazines; Pyrrolidines; Receptor, Melanocortin, Type 4; Structure-Activity Relationship

2007
The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:2

    Topics: Amides; Amino Acids; Ethylenes; Humans; Hydrophobic and Hydrophilic Interactions; Piperazine; Piperazines; Protein Binding; Pyrrolidines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Small Molecule Libraries; Structure-Activity Relationship

2009
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:11

    Topics: Amides; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Feces; Female; Humans; Hydrolysis; Hydroxylation; Male; Metabolic Detoxication, Phase II; Microsomes, Liver; Molecular Docking Simulation; Piperazine; Piperazines; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley

2012
Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes.
    Chemical biology & drug design, 2015, Volume: 85, Issue:4

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Piperazine; Piperazines; Pyrrolidines

2015
Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.
    Bioorganic & medicinal chemistry, 2015, Jun-01, Volume: 23, Issue:11

    Topics: Combinatorial Chemistry Techniques; Drug Discovery; Heterocyclic Compounds; Lithium; Molecular Structure; Organometallic Compounds; Piperazine; Piperazines; Piperidines; Pyrrolidines; Small Molecule Libraries

2015
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
    European journal of medicinal chemistry, 2021, Jul-05, Volume: 219

    Topics: Antimalarials; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Humans; Nucleotides; Pentosyltransferases; Piperazine; Piperidines; Plasmodium falciparum; Plasmodium vivax; Prodrugs; Protozoan Proteins; Pyrrolidines; Structure-Activity Relationship

2021
Design, synthesis, and biological evaluation of quinoline-piperazine/pyrrolidine derivatives as possible antileishmanial agents.
    European journal of medicinal chemistry, 2023, Dec-05, Volume: 261

    Topics: Antiprotozoal Agents; Leishmania donovani; Piperazine; Quinolines

2023