piperazine has been researched along with pyrrolidine in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Chen, C; Chen, CW; Fleck, BA; Jiang, W; Tran, JA; Tucci, FC | 1 |
| Basista, K; Bojarski, AJ; Duszyńska, B; Martinez, J; Obniska, J; Pawłowski, M; Subra, G; Verdie, P; Zajdel, P | 1 |
| Dai, H; Doran, SD; Piotrowski, DW; Prakash, C; Ryder, TF; Sharma, R; Sun, H | 1 |
| Haq, W; Katti, SB; Kushwaha, RN; Mishra, A; Rawat, AK; Srivastava, AK; Srivastava, R | 1 |
| Atobe, M; Bond, PS; Fairlamb, IJ; Haji-Cheteh, C; Hubbard, RE; Lüthy, M; O'Brien, P; Wheldon, MC | 1 |
| Chavchich, M; Dračínský, M; Edstein, MD; Frydrych, J; Guddat, LW; Hocková, D; Janeba, Z; Keough, DT; Travis, J | 1 |
| Ansari, A; Bhatta, RS; Bisen, AC; Goyal, N; Katiyar, S; Kumar, A; Mishra, G; Purkait, B; Ramalingam, K; Sanap, SN; Sashidhara, KV | 1 |
1 review(s) available for piperazine and pyrrolidine
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
7 other study(ies) available for piperazine and pyrrolidine
| Article | Year |
|---|---|
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
Topics: Amides; Carboxylic Acids; Chlorine Compounds; Cyclohexanes; Ligands; Molecular Structure; Piperazine; Piperazines; Pyrrolidines; Receptor, Melanocortin, Type 4; Structure-Activity Relationship | 2007 |
The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.
Topics: Amides; Amino Acids; Ethylenes; Humans; Hydrophobic and Hydrophilic Interactions; Piperazine; Piperazines; Protein Binding; Pyrrolidines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Small Molecule Libraries; Structure-Activity Relationship | 2009 |
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Topics: Amides; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Feces; Female; Humans; Hydrolysis; Hydroxylation; Male; Metabolic Detoxication, Phase II; Microsomes, Liver; Molecular Docking Simulation; Piperazine; Piperazines; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2012 |
Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Piperazine; Piperazines; Pyrrolidines | 2015 |
Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.
Topics: Combinatorial Chemistry Techniques; Drug Discovery; Heterocyclic Compounds; Lithium; Molecular Structure; Organometallic Compounds; Piperazine; Piperazines; Piperidines; Pyrrolidines; Small Molecule Libraries | 2015 |
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
Topics: Antimalarials; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Humans; Nucleotides; Pentosyltransferases; Piperazine; Piperidines; Plasmodium falciparum; Plasmodium vivax; Prodrugs; Protozoan Proteins; Pyrrolidines; Structure-Activity Relationship | 2021 |
Design, synthesis, and biological evaluation of quinoline-piperazine/pyrrolidine derivatives as possible antileishmanial agents.
Topics: Antiprotozoal Agents; Leishmania donovani; Piperazine; Quinolines | 2023 |